Janice L Gabrilove, MD
- PROFESSOR | Medicine, Hematology and Medical Oncology
- PROFESSOR | Oncological Sciences
Specialties:Hematology-Oncology, Cancer (Oncology)
Research Topics:Bioinformatics, Biophysics, Computational Biology, Computer Simulation, Drug Design and Discovery, Integrins, Mathematical and Computational Biology, Membrane Proteins/Channels, Protein Complexes, Protein Structure/Function, Signal Transduction, Theoretical Biology, Theoretical Biophysics
American Board of Internal Medicine
- Acute Lymphoid Leukemia
- Acute Myeloid Leukemia
- Adult Non-Hodgkin's Lymphoma
- Bone Marrow Biopsy
- Hematologic Malignancies
- Hodgkin's Disease
- Hodgkin's Lymphoma
- LGL Leukemia
- Myelodysplastic Syndromes
- Waldenström's Macroglobulinemia
Multi-Disciplinary Training AreaClinical Research Education Program [CLR]
MD, Mount Sinai School of Medicine
Residency, Internal Medicine, Columbia-Presbyterian Medical Ctr.
Fellowship, Hematology/Oncology, Memorial Sloan-Kettering
Role of Hematopoietic Factors in Normal Hematopoietic Cell Reconstitution
Dr. Gabrilove is a pioneer in the development of our understanding of the biology of hematopoietic growth factors and their clinical utility in promoting hematopoietic reconstitution. She is a co-inventor on the patent describing the initial isolation and characterization of human granulocyte colony stimulating factor (G-CSF), which is used in the treatment of chemotherapy induced myelosuppression and severe chronic neutropenia. Her initial studies also demonstrated the ability of G-CSF to mobilize progenitor cells into the peripheral blood (PBPC). This observation has revolutionized the way in which we perform marrow transplantation today, which is conducted almost exclusively utilizing G-CSF mobilized PBPC. This laboratory is currently investigating:
Menzel T, Rahman Z, Calleja E, White K, Wilson EL, Wieder R, Gabrilove J. Elevated intracellular level of basic fibroblast growth factor correlates with stage of chronic lymphocytic leukemia and is associated with resistance to fludarabine. Blood 1996; 87: 1056-1063.
Welte K, Gabrilove J, Bronchud MH, Platzer E, Morstyn G. Filgrastim (r-metHuG-CSF.). The first ten years. Blood 1996; 88: 1907-1929.
Jakubowski A, Gabrilove J. Granulocyte colony stimulating factor (G:CSF). Biology and clinical status. Cancer, Biotherapy & Radiopharmaceutics 1996; 11: 5-20.
Konig A, Wrazel L, Warrell RP, Rivi R, Pandolfi PP, Jakubowski A, Gabrilove J. Comparative activity of melarsoprol and arsenic trioxide in chronic B cell leukemia lines. Blood 1997; 90: 562-570.
Konig A, Menzel T, Lynen S, Rosen A, Raveche E, Gabrilove J. Basic fibroblast growth factor (bFGF) upregulates the expression of bcl-2 in chronic lymphocytic leukemia cell lines resulting in delaying apoptosis. Leukemia 1997; 11: 258-272.
Moskowitz CH, Stiff P, Gordon MS, McNiece I, Ho AD, Costa JJ, Broun ER, Bayer RA, Wyres M, Hill J, Jelaca-Maxwell K, Nichols CR, Brown SL, Nimer SD, Gabrilove J. Recombinant methionyl human stem cell factor (r-metHuSCF) and filgrastim for PBPC mobilization and transplantation in non-Hodgkin's lymphoma patients - results of a phase I/II trial. Blood 1997; 89: 3136-3147.
Shapiro R, Yao TJ, Moskowitz C, Reich L, Wuest DL, Heirnfeld S, McNiece IK, Gabrilove J, Nimer S, Moore MA. Effects of prior therapy on the in vitro proliferative potential of stem cell factor plus filgrastim-mobilized CD34-positive progenitor cells. Clin Cancer Res 1997; 3: 1571-1578.
Wieder R, Wang H, Shike S, Wang Q, Menzel T, Feirt N, Jakubowski AA, Gabrilove J. Low level expression of basic FGF upregulates Bcl-2 and delays apoptosis, but high intracellular levels are required to induce transformation in NIH 3T3 cells. Growth Factors 1997; 15: 41-60.
Konig A, Schwartz GK, Mohammad RM, Al-Katib A, Gabrilove J. The novel cyclin-dependent kinase inhibitor flavopiridol downregulates bcl-2 and induces growth arrest and apoptosis in chronic B cell leukemia lines. Blood 1997; 90: 4307-4312.
Soignet SL, Maslak P, Wang ZG, Jhanwar S, Calleja E, Dardashti LJ, Corso D, DeBlasio A, Scheinberg DA, Gabrilove J, Pandolfi PP, Warrell RP. Complete remission after induction of non-terminal differentiation and apoptosis in acute promyelocytic leukemia by arsenic trioxide. N Engl J Med 1998; 339: 1341-1348.
Wang Z, Rivi R, Delva L, Konig A, Scheinberg DA, Gambacorti-Passerini C, Gabrilove J, Warrell RP, Pandolfi PP. Aresnic trioxide and melarsoprol induce programmed cell death in myeloid leukemia cell lines and function in a PML and PML-RARa independent manner. Blood 1998; 92: 1497-1504.
Xu Y, Lai LT, Gabrilove J, Scheinberg DA. Antitumor activity of actinoniun in vitro and in vivo. Clin Cancer Res 1998; 4: 171-176.
Waltzman RJ, Gabrilove J. Challenges of treating cancer-related fatigue. Oncology Special Edition 2000; 3: 129-132.
Gabrilove J, Einhorn L, Cleeland C, Livingston R, Weiner E, Waltzman RJ. Efficacy of a once-weekly dosage regimen of epoetin alfa in hematologic malignancies. International Society of Hematology 2000 Supplement 1; 72: 55.