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Jeffrey Silbiger

  • ASSOCIATE PROFESSOR Medicine, Cardiology
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  • M.D., New York Medical College

  • B.S., City College of New York


    Dr. Silbiger joined the faculty of the Icahn School of Medicine at Mount Sinai after completing his fellowship training in cardiology at Beth Israel Medical Center in New York City. He is board certified in internal medicine, cardiovascular diseases and adult echocardiography. Dr. Silbiger is a fellow of the American College of Cardiology as well as of the the American Society of Echocardiography, where he sits as a member of the Continuing Medical Education Committee. Dr. Silbiger is presently associate professor of medicine and serves as director of the Echocardiography Laboratory at Elmhurst Hospital Center, a major teaching campus for Mount Sinai‚Äôs Clinical Track Cardiology Fellowship Training Program. His research interests include the functional anatomy of the mitral annulus, the structural mechanics of functional mitral regurgitation and coronary artery disease in high risk immigrant  populations.   



  • It is thought that left atrium plays a major role in facilitating mitral annular contraction, however, precise structural and mechanical details remain poorly understood. We are performing gross and microscopic anatomic studies in the bovine heart to identify the anatomic substrate of annular contraction. An improved understanding of  annular mechanics could have significant implications for future mitral annuloplasty ring designs.
  • Heterogeneity in the severity of functional mitral regurgitation is commonly observed in clinical practice, however, the mechanical basis of this phenomenon is incompletely understood. Using two and three-dimensional echocardiography and echocardiographic strain imaging, we are studying the role that alterations in regional left ventricular wall stress, papillary muscle function and ventriculo-valvular interaction play in determining mitral regurgitant burden.  An improved understanding of the structural mechanics of functional mitral regurgitation could have important implications for the design of future device therapies. 
  • South Asian immigrants have a significantly higher prevalence of coronary artery disease than Caucasians and also suffer from more premature and clinically aggressive disease. We have undertaken studies to characterize the risk factor burden and angiographic findings of South Asian and Indo-Guyanese immigrants living in New York City. These suggest that aggressive screening and risk factor modification may be indicated in these populations.


Silbiger JJ, Singh T. Is Left Ventricular End Systolic Dimension a Reliable Predictor of Post-Operative Left Ventricular Dysfunction in Patients with Mitral Regurgitation Secondary to Mitral Valve Prolapse? . J Am Soc Echocardiogr 2016; 29: 181-182.

Silbiger JJ. Viewpoint: Does Left Atrial Enlargement Contribute to Mitral Leaflet Tethering in Patients With Functional Mitral Regurgitation? Proposed Role of Atriogenic Leaflet Tethering.. Echocardiography 2014; 31: 1310-1311.

Silbiger JJ. Novel Pathogenetic Mechanisms and Structural Adaptations in Ischemic Mitral Regurgitation. J Am Soc Echocardiogr 2013; 26: 1107-1117.

Silbiger JJ. Left Ventricular False Tendons: Anatomic, Echocardiographic and Pathophysiologic Insights. J Am Soc Echocardiogr 2013; 26: 582-588.

Silbiger JJ, Stein R, Roy M, Nair M, Cohen P, Shaffer J, Pinkhasov A, Kamran M. Coronary Artery Disease in South Asian Immigrants Living in New York City: Angiographic Findings and Risk Factor Burdens . Ethn Dis 2013; 23: 292-295.

Silbiger JJ. Editorial: Transcutaneous Aortic Valve Implantation in Patients with Combined Aortic Stenosis and Mitral Regurgitation: Does the Choice of Prosthesis Matter?. Echocardiography 2012; 30: 245-247.

Silbiger JJ. A Novel Mechanism by Which MitraClip Implantation May Favorably Alter the Natural History of Left Ventricular Remodeling in Patients With Mitral Regurgitation: Proposed Role of the Venticular-Valvular Loop. J Am Soc Echocardiogr 2012; 26: 217-219.

Silbiger JJ. Anatomy, Mechanics and Pathophysiology of the Mitral Annulus. Am Heart J 2012; 164: 163-176.

Silbiger JJ, Stein R, Trost B, Shaffer J, Hee-Kim J, Cohen P, Kamran M. Coronary Angiographic Findings and Conventional Coronary Artery Disease Risk Factors in Indo-Guyanese Immigrants with Stable Angina Pectoris and Acute Coronary Syndromes. Ethn and Dis 2012; 22: 12-15.

Silbiger JJ. Mechanistic Insights into Ischemic Mitral Regurgitation: Echocardiographic and Surgical Implications. J Am Soc Echocardiogr 2011; 24: 707-719.

Silbiger JJ, Ashtiani R, Attari M, Spruill TM, Kamran M, Reynolds D, Stein R, Rubinstein D. Atherosclerotic Heart Disease in Bangladeshi Immigrants: Risk Factors and Angiographic Findings . Int J Cardiol 2011; 146: 38-40.

Silbiger JJ, Bazaz R. Contemporary Insights into the Functional Anatomy of the Mitral Valve. Am Heart J 2009; 158: 887-895.

Silbiger JJ. The Cardiac Manifestations of Antiphospholipid Syndrome and their Echocardiographic Recognition. J Am Soc Echocardiogr 2009; 22: 1100-1108.

Silbiger JJ. Mitral Valve Aneurysms in Infective Endocarditis: Mechanisms, Clinical Features and Treatment. J Heart Valve Dis 2009; 18: 476-480.

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. Silbiger did not report having any of the following types of financial relationships with industry during 2015 and/or 2016: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.

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