Jeremy Leventhal, MD
- ASSISTANT PROFESSOR | Medicine, Nephrology
Research Topics:Autophagy, Kidney
BS, Cornell University
MD, Icahn School of Medicine at Mount Sinai
Autophagy is an intracellular catabolic mechanism that has recently been recognized as a modulator of human health and disease. The research done in this lab involves looking at how altered autophagy affects kidney disease.
Acute kidney injury (AKI) is common in hospitalized patients and is associated with worsened short-term and long-term outcomes including increased in-hospital mortality and higher long-term risks of developing ESRD. Because infection (sepsis) is a common etiology of kidney injury in hospitalized patients and is especially associated with poor outcomes, we are working to determining how autophagy protects the kidney from injury during infection. Additionally, we are beginning to investigate how disturbances in autophagy may further the destructive kidney changes and fibrosis that characterizes chronic kidney disease (CKD) in patients.
Leventhal JS, He JC, Ross MJ. Autophagy and immune response in kidneys. Seminars in nephrology 2014 Jan; 34(1).
Potla U, Ni J, Vadaparampil J, Yang G, Leventhal JS, Campbell KN, Chuang PY, Morozov A, He JC, D'Agati VD, Klotman PE, Kaufman L. Podocyte-specific RAP1GAP expression contributes to focal segmental glomerulosclerosis-associated glomerular injury. The Journal of clinical investigation 2014 Apr; 124(4).
Cravedi P, Leventhal J, Lakhani P, Ward SC, Donovan MJ, Heeger PS. Immune cell-derived C3a and C5a costimulate human T cell alloimmunity. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2013 Oct; 13(10).
Leventhal JS, Schröppel B. Toll-like receptors in transplantation: sensing and reacting to injury. Kidney international 2012 May; 81(9).
Leventhal JS, Alsauskas Z, Snyder A, Gong P, Wang B, D'Agati V, Ross MJ. Renal HIV expression is unaffected by serum LPS levels in an HIV transgenic mouse model of LPS induced kidney injury. PloS one 2011; 6(6).
Synder A, Alsauskas Z, Leventhal J. HIV-1 viral protein r induces ERK and caspase-8-dependent apoptosis in renal tubular epithelial cells.. AIDS 2010; 24: 1107-1119.
Mehrotra A, Leventhal J, Purroy C, Cravedi P. Monitoring T cell alloreactivity. Transplantation reviews (Orlando, Fla.) 2014 Nov;.
Leventhal JS, Ross MJ. Pathogenesis of HIV-associated nephropathy. Seminars in nephrology 2008 Nov; 28(6).