Photo of Jeremy Leventhal

Jeremy Leventhal

  • ASSISTANT PROFESSOR Medicine, Nephrology
Print ProfilePrint Profile


  • BS, Cornell University

  • MD, Icahn School of Medicine at Mount Sinai



Autophagy is an intracellular catabolic mechanism that has recently been recognized as a modulator of human health and disease. The research done in this lab involves looking at how altered autophagy affects kidney disease.
Acute kidney injury (AKI) is common in hospitalized patients and is associated with worsened short-term and long-term outcomes including increased in-hospital mortality and higher long-term risks of developing ESRD.  Because infection (sepsis) is a common etiology of kidney injury in hospitalized patients and is especially associated with poor outcomes, we are working to determining how autophagy protects the kidney from injury during infection. Additionally, we are beginning to investigate how disturbances in autophagy may further the destructive kidney changes and fibrosis that characterizes chronic kidney disease (CKD) in patients.  


Leventhal JS, He JC, Ross MJ. Autophagy and immune response in kidneys. Seminars in nephrology 2014 Jan; 34(1).

Potla U, Ni J, Vadaparampil J, Yang G, Leventhal JS, Campbell KN, Chuang PY, Morozov A, He JC, D'Agati VD, Klotman PE, Kaufman L. Podocyte-specific RAP1GAP expression contributes to focal segmental glomerulosclerosis-associated glomerular injury. The Journal of clinical investigation 2014 Apr; 124(4).

Cravedi P, Leventhal J, Lakhani P, Ward SC, Donovan MJ, Heeger PS. Immune cell-derived C3a and C5a costimulate human T cell alloimmunity. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2013 Oct; 13(10).

Leventhal JS, Schröppel B. Toll-like receptors in transplantation: sensing and reacting to injury. Kidney international 2012 May; 81(9).

Leventhal JS, Alsauskas Z, Snyder A, Gong P, Wang B, D'Agati V, Ross MJ. Renal HIV expression is unaffected by serum LPS levels in an HIV transgenic mouse model of LPS induced kidney injury. PloS one 2011; 6(6).

Synder A, Alsauskas Z, Leventhal J. HIV-1 viral protein r induces ERK and caspase-8-dependent apoptosis in renal tubular epithelial cells.. AIDS 2010; 24: 1107-1119.

Mehrotra A, Leventhal J, Purroy C, Cravedi P. Monitoring T cell alloreactivity. Transplantation reviews (Orlando, Fla.) 2014 Nov;.

Leventhal JS, Ross MJ. Pathogenesis of HIV-associated nephropathy. Seminars in nephrology 2008 Nov; 28(6).

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. Leventhal did not report having any of the following types of financial relationships with industry during 2014 and/or 2015: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.

Edit profile in Sinai Central


Annenberg Building Floor 23 Room 68C
1180 Fifth Avenue
New York, NY 10029

Tel: 212-241-8539
Fax: 212-987-0389


Annenberg Building Floor 23 Room 68C
1180 Fifth Avenue
New York, NY 10029