- ASSISTANT PROFESSOR Neuroscience
- ASSISTANT PROFESSOR Structural and Chemical Biology
Ph.D. University of Illinois, 1998
B.Sc. Peking University, 1987
See Lab webpage for more details
Interneuronal functions in complex behaviorsWe study how neural systems generate complex behaviors. We use a model system, the marine mollusk, Aplysia californica. Because neural networks in Aplysia contain a relatively small number of elements, Aplysia is well suited for such studies. Currently, we seek to gain insights into the question how is the activity of neurons that control distinct motor structures coordinated to generate functional behaviors. Our work is unique in that the focus of most other investigators is on how coordination is achieved within a single motor structure.
Our previous work was focused on the generation of behaviors by a single motor structure. This work investigated issues of neural coding, behavioral selection (decision making), and neuromodulation. Importantly, this work also identified a number of interneurons and processes that are likely to play a major role in coordinating motor outputs of distinct peripheral structures. Specifically, because various forms of coordination are to a large extent implemented by interneurons, a major goal of our research is to study functions of interneurons. We study neural circuits in considerable detail, both in terms of component neurons, and synaptic connections between these neurons. Furthermore, we identify the neurotransmitters/neuromodulators in these neurons using a variety of techniques, and study the functions of these neurotransmitters.
Independent of how complex animals are, their behaviors need to be coordinated to be successful. Therefore, we expect that basic mechanisms and principles uncovered in our research will have important implications for understanding how motor coordination is achieved in higher animals.
Jing J, Sasaki K, Perkins MH, Siniscalchi MJ, Ludwar BC, Cropper EC, Weiss KR. Coordination of distinct motor structures through remote axonal coupling of projection interneurons. J Neurosci 2011;.
Jing J, Sweedler JV, Cropper EC, Alexeeva V, Park J, Romanova EV, Xie F, Dembrow NC, Ludwar BC, Weiss KR, Vilim FS. Feedforward compensation mediated by the central and peripheral actions of a single neuropeptide discovered using representational difference analysis. J Neurosci 2010; 30: 16545-16558.
Wu J, Vilim FS, Hatcher NG, Due MR, Sweedler JV, Weiss KR, Jing J. Composite modulatory feedforward loop contributes to the establishment of a network state. J Neurophysiol 2010; 103: 2174-2184.
Jing J, Gillette R, Weiss KR. Evolving concepts of arousal: insights from simple model systems. Rev Neurosci 2009; 20: 405-427.
Sasaki K, Brezina V, Weiss KR, Jing J. Distinct inhibitory neurons exert temporally specific control over activity of a motoneuron receiving concurrent excitation and inhibition. J Neurosci. 2009 Sep 23; 29(38): 11732-11744.
Jing J, Vilim FS, Cropper EC, Weiss KR. Neural analog of arousal: persistent conditional activation of a feeding modulator by serotonergic initiators of locomotion. J Neurosci 2008 Nov 19; 28(47): 12349-12361.
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Dr. Jing did not report having any of the following types of financial relationships with industry during 2012 and/or 2013: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
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