- ASSISTANT PROFESSOR Pediatrics, Newborn Medicine
Neonatal & Perinatal Medicine
MD, Wenzhou Medical College
University of Miami
Yuying Children's Hospital
New York University Medical Center
Mount Sinai Hospital
ResearchDr. Lin's main research focus is on the role of short chain fatty acids (SCFAs) in the pathogenesis of neonatal necrotizing enterocolitis (NEC), a disease mainly seen in premature infants and a source of significant morbidity and mortality in the NICU. The existing data suggest that production of SCFAs in the bowel under normal conditions is very important for energy salvage and crucial for gastrointestinal adaptation and maturation; however, excessive SCFAs, especially butyrate, in the intestinal lumen can deregulate the normal process of apoptosis and may cause disruption of the intestinal barrier. The increased apoptosis can have a detrimental effect on intestinal barrier function. Once the intestinal barrier is disrupted, the inflammatory cascade may be activated, which can induce further injury to the intestinal mucosa including areas of the intestine distant from the initial disruption. Therefore overproduction/accumulation of SCFAs in the intestinal lumen may play a pivotal role in the pathogenesis of NEC. The experiments in Dr. Lin's lab are designed to elucidate the effects of butyrate on the intestinal mucosa barrier at different developmental stages and the underlying mechanisms, which may help us to further understand the important role of butyrate in postnatal intestinal barrier maturation and the pathogenesis of NEC. These insights may lead to the development of novel prevention strategies.
Howe TH, Sheu CF, Hinojosa J, Lin J, Holzman IR. Multiple factors related to bottle-feeding performance in preterm infants. Nurs Res 2007; 56: 307-311.
Gibbs K, Lin J, Holzman IR. Necrotizing enterocolitis: the state of the science. Indian J Pediatrics 2007; 74: 67-72.
Peng LY, He ZJ, Chen W, Holzman IR, Lin J. Effects of short chain fatty acid on intestinal barrier function in a Caco-2 cell monolayer model. Pediatr Res 2007; 61: 37-41.
Lin ZL, Yu HM, Lin J, Chen SQ, Liang ZQ, Zhang ZY. Mild hypothermia via selective head cooling as neuroprotective therapy in term neonates with perinatal asphyxia: an experience from a single neonatal intensive care unit. J Perinatol 2006; 26: 180-184.
Lin J, Peng LY, Itzkowitz S, Holzman IR, Babyatsky MW. Short-chain fatty acid induces intestinal mucosal injury in newborn rats and down-regulates intestinal trefoil factor gene expression in vivo and in vitro. J Pediatr Gastr Nutr 2005; 41: 607-611.
Nafday SM, Green RS, Lin J, Oschorn I, Brion L, Holzman IR. Is there an advantage of using pressure support ventilation with volume guarantee in the initial management of premature infants with respiratory distress syndrome? - A pilot study. J Perinatol 2005; 25: 193-197.
Nafday SM, Peng LY, Babyatsky MW. Short chain fatty acids induce colonic mucosal injury in rats with different postnatal ages. Pediatr Res 2005; 57: 201-204.
Yu K, Jiang SF, Lin MF, Wu JB, Lin J. Extraction and purification of biologically active intestinal trefoil factor from human meconium. Lab Invest 2004; 84: 390-392.
Lin J. Too much short chain fatty acids cause neonatal necrotizing enterocolitis. Med Hypotheses 2004; 62: 291-293.
Lin J, Nadroo AM, Chen W, Fan QX, Holzman IR, Babyatsky MW. Ontogeny and prenatal expression of trefoil factor 3/ITF in the human intestine. Early Hum Dev 2003; 71: 103-109.
Peng LY, Li ZR, Green RS, Holzman IR, Lin J. Butyrate Enhances the Intestinal Barrier by Facilitating Tight Junction Assembly via Activation of AMP Activated Protein Kinase in Caco-2 Cell Monolayers. J Nutr 2009; 139: 1619-25.
Hu GX, Chen GR, Xu H, Ge RS, Lin J. Activation of the AMP activated protein kinase by short chain fatty acids is the main mechanism underlying the beneficial effect of a high fiber diet on the metabolic syndrome. Medical Hypotheses 2010; 74: 123-126.
Chen SQ, Chen JN, Cai XH, Chen GR, Gao Y, Ge RS, Wu HS, Lin ZL, Lin J. Perinatal exposure to di-(2-ethylhexyl) phthalate leads to restricted growth and delayed lung maturation in newborn rats. J Perinat Med 2010; 38: 515-521.
Liu XL, Zhou R, Pan QQ, Jia XL, Gao WN, Wu J, Lin J, Chen JF. Genetic inactivation of the adenosine A2A receptor attenuates pathological but not developmental angiogenesis in mouse retina. Invest Ophthalmol Vis Sci 2010; 51: 6625-6632.
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Dr. Lin did not report having any of the following types of financial relationships with industry during 2012 and/or 2013: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.
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