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Kurt Hirschhorn

  • PROFESSORIAL LECTURER Genetics and Genomic Sciences
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  • Clinical Cytogenetics

  • Clinical Genetics

  • Clinical Biochemical Genetics

  • American Board of Internal Medicine


  • MD, New York University

  • Residency, Internal Medicine
    New York University Medical Center

  • Residency, Internal Medicine
    New York University Medical Center

  • Fellowship, Metabolism
    Bellevue Hospital

  • Fellowship, Genetics
    State Institute of Human Genetics

  • Fellowship, Research
    American Heart Association


    Dr. Kurt Hirschhorn is the Professor Emeritus of Pediatrics, Genetics and Medicine, and Chairman Emeritus of Pediatrics. He received his medical degree in 1954 from New York University School of Medicine. He was elected to both Phi Beta Kappa and Alpha Omega Alpha. He served his residency in internal medicine at Bellevue Hospital, New York, and remained there as a Fellow in Metabolic Diseases and then had a Fellowship in Human Genetics in Uppsala, Sweden. He was awarded a master of science in Internal Medicine and Genetics in 1958, when he became Assistant Professor and then Associate Professor of Medicine at New York University School of Medicine. He became Professor of Pediatrics at Mount Sinai School of Medicine in New York in 1966 where he established a new Medical Genetics Program.  From 1968 to 1976 he was the Arthur J. and Nellie Z. Cohen Professor of Genetics at Mount Sinai School of Medicine.  In 1977, he became the Herbert H. Lehman Professor and Chairman of the Department of Pediatrics at Mount Sinai School of Medicine and Pediatrician‑in‑Chief at Mount Sinai Hospital. In 1995, he stepped down from the chairmanship and returned to research in human genetics as a Professor of Pediatrics, Human Genetics and Medicine.

    Dr. Hirschhorn continues to be actively involved in research and in the clinical practice of medical genetics. His work includes research and application of the various subdisciplines of genetics including cytogenetics, biochemical genetics and molecular genetics. He is one of the founding members of The Hastings Center for Biomedical Ethics and chaired the Medical Board Ethics Committee at Mount Sinai Hospital for 30 years. His longstanding interest and leadership in medical genetics has resulted in the publication of more than 400 articles. He has received many national and international honors, including membership in the Institute of Medicine of the National Academy of Sciences.


  • 2013 -
    Victor A. McKusick Leadership Award
    American Society of Human Genetics

  • 2006 -
    The John Howland Award for Distinguished Service to Pediatrics
    The American Pediatric Society

  • 2002 -
    Award for Excellence in Human Genetics Education
    American Society of Human Genetics

  • 1995 -
    William Allan Award
    American Society of Human Genetics

  • 1982 -
    The Solomon A. Berson Medical Alumni Achievement Award in Clinical Science
    New York University School of Medicine, NY


1.    Cytogenetics
a.    Use of molecular and cytogenetic techniques such as in situ hybridization, comparative genomic hybridization (CGH) and/or FISH for refined diagnosis and mapping of genetic loci.
 b.    Chromosomal Abnormalities: Use of chromosome elongation (late prophase preparations), newer banding techniques and FISH to characterize structural alterations in chromosomes of parents with congenital malformation syndromes and in couples with infertility/recurrent miscarriages.
2.    Clinical Genetics/Prenatal Diagnosis:
a.    Application of genetic technology to the diagnosis, management and treatment of patients and families with genetic disease.
b.    Delineation of new syndromes.
c.    Genetic counseling methodology and assessment.
d.    Prenatal Genetics: Studies designed to develop new and improved  methods for the prenatal diagnosis and/or treatment of chromosomal, biochemical or multifactorial disorders. Preimplantation diagnosis by CGH to detect chromosomal abnormalities in polar bodies and 8-cell embryos.    Application of molecular diagnostic techniques for precise diagnosis of disorders whose genes are expressed in specific tissues. Analysis of fetal cells in maternal blood and in the endocervical canal.


Levy B, Hirschhorn K. Tetrasomy 15q26: a distinct syndrome or Shprintzen-Goldberg syndrome phenocopy? . Genet. In Med 2012; 14: 811-818 .

Rhodes R, Hirschhorn K. De minimis risk: a proposal for a new category of research risk. . Am. J. Bioeth 2011; 11: 1-7.

Edelmann L, Hirschhorn K. Clinical utility of array CGH for the detection of chromosomal imbalances associated with mental retardation and multiple congenital anomalies.. Ann. N.Y. Acad. Sci. 2009; 1151: 157-166 .

Edelmann L, Hirschhorn K. Multiple hemangiomas in a patient with a t(3q;4p) translocation: an infrequent association with Wolf-Hirschhorn Syndrome. . Am. J. Med. Genet 2008; 146: 219-224 .

Levy B, Hirschhorn K. The incidence and spectrum of chromosome abnormalities in spontaneous abortions – New insights from a 12-year study.. Genet. in Med 2005; 7: 251-263 .

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. Hirschhorn did not report having any of the following types of financial relationships with industry during 2015 and/or 2016: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.

Insurance Information

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Tel: 212-241-4305
Fax: 212-426-4371
Annenberg Building

1468 Madison Avenue
Room 1790-E
New York, NY 10029

Tel: 212-241-4305
Fax: 212-426-4371
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