Specialty
Certifications
Pediatric Nephrology
American Board of Pediatrics
Clinical Focus
- Electrolyte problems, acidosis
- Genetic kidney diseases
- Hypertension (high blood pressure)
- Kidney cysts
Research Topics
- Biomechanics/Bioengineering
- Cell Biology
- Cellular Differentiation
- Cytoskeleton
- Developmental Biology
- Electrophysiology
- Epithelial Cells
- Gene Expressions
- Growth
- Growth Factors and Receptors
- Hormones
- Imaging
- Kidney
- Knockout Mice
- Membrane Proteins/Channels
- Membranes
- Phosphorylation
- Protein Complexes
- Protein Kinases
- Protein Phosphatases
- Protein Trafficking & Sorting
- Signal Transduction
- Trafficking
- Transporters
- Two-Photon Imaging
Training Areas
Education
MD, Columbia Univ. Col. of Phy. & Surg.
Residency, Pediatrics
Columbia-Presbyterian Medical Ctr.Fellowship, Nephrology
Albert Einstein College of Medicine
Biography
Lisa Satlin is a Professor and Chair of the Department of Pediatrics at the Mount Sinai School of Medicine (MSSM), where she is also an Associate Director of the MD/PhD Training Program and Director of the Center for Patient Oriented Research, Training, Education and Development (CePORTED), the education arm of Mount Sinai’s Clinical and Translational Science Award. She received her MD degree from Columbia University College of Physicians and Surgeons, and completed a residency in Pediatrics at the Babies Hospital of Columbia University and a Pediatric Nephrology Fellowship at the Albert Einstein College of Medicine. At MSSM, as Division Chief of the Division of Pediatric Nephrology (1997-2010), Dr. Satlin built an internationally respected academic division and an ACGME-accredited Pediatric Nephrology Fellowship training program, which has attracted both physician and research trainees interested in clinical nephrology and basic research related to developmental nephrology, respectively. She continues to run an active NIH-supported laboratory, supported in part to serve as a national “Single Tubule Physiology Core” as part of an O’Brien Renal Research Center, focused on defining the mechanisms leading to the acquisition, maintenance and regulation of transepithelial transport in the renal collecting duct, the nephron segment responsible in the adult for the final regulation of salt and water homeostasis. Her research accomplishments have been recognized by her election to membership in the Society for Pediatric Research, the American Pediatric Society, and the Association of American Physicians.
Dr. Satlin is the immediate Past-President of the American Society of Pediatric Nephrology and is currently a Councilor of the International Pediatric Nephrology Association. She continues in her second term as Associate Editor of the American Journal of Physiology: Renal Physiology, and has participated in many study sections and grant-review groups for the NIH and the American Heart Association.
Awards
2009 -
Best Doctors
New York Magazine2008 - 2011
Listed in New York Super Doctors
2006 - 2012
New York Metro Area Top Doctor
Castle Connelly2003 - 2012
Listed in Best Doctors in America
Research
The focus of our lab is directed at defining the mechanisms leading to the acquisition, maintenance and regulation of transepithelial transport in the renal cortical collecting duct (CCD), the nephron segment responsible in the adult for the final renal regulation of potassium (K) and sodium (Na) homeostasis. In the CCD, urinary Na diffuses into principal cells through apical Na channels (ENaCs) and is extruded at the basolateral membrane in exchange for uptake of K by the Na-K pump. Cell K passively diffuses out of the cell down a favorable electrochemical gradient into the luminal fluid through apical K-selective (SK or ROMK) channels. Recent evidence from our laboratory indicates that high rates of tubular fluid flow activate apical maxi-K channels in a Ca2+-dependent manner. Using a combination of molecular, electrophysiologic, and functional techniques, we are exploring following two major areas of investigation.
Developmental regulation of ion channels in the distal nephron: Kidneys of growing subjects efficiently retain urinary K and Na. In contrast to the high rates of net K secretion observed in CCDs isolated from adult animals, segments from neonatal animals show no K transport and a paucity of conducting apical K channels. Yet, the same neonatal segments possess functional ENaC channels and absorb Na at a rate half that measured in the adult. Studies are underway to discern whether the appearance of conducting SK, maxi-K, and ENaC channels is regulated by transcription, translation, and/or post-translational processing. The role of epigenetic factors (diet and hormones) and signaling molecules in the regulation of gene and protein expression, channel activity, and tubular transport in the differentiating CCD are being explored.
Epithelial transport in polycystic kidney disease (PKD): Autosomal recessive PKD (ARPKD), a disease associated with a high morbidity, is characterized by the progressive dilatation of CCDs and early onset of hypertension. We have sought to identify whether alterations in expression and regulation of epithelial cell transport pathways contribute to disease progression. Preliminary data indicates that cyst-lining cells are capable of avid Na absorption and maintaining steep transepithelial ion gradients. Studies are ongoing to examine the molecular basis for this observation, specifically focusing on exploring the impact of mispolarized EGFR on activity of the major channel, transporter, and receptor proteins involved in solute and water transport in kidney cell lines derived from ARPKD and age-matched normal kidneys.
Publications
Sun P, Liu W, Lin DH, Yue P, Kemp R, Satlin LM, Wang WH. Epoxyeicosatrienoic acid activates BK channels in the cortical collecting duct. J. Am. Soc. Nephrol 2009; 20: 513-520.
Estilo G, Liu W, Pastor-Soler N, Mitchell P, Kleyman T, Satlin LM. Effect of mineralocorticoids on maxi-K channel expression in the cortical collecting duct (CCD). Am. J. Physiol. Renal Physiol 2008; 295: F780-F788.
Rohatgi R, Battini L, Kim P, Israel S, Wilson PD, Gusella GL, Satlin LM. Mechanoregulation of intracellular Ca2+ in human autosomal recessive polycystic kidney disease (ARPKD) cyst-lining renal epithelial cells. Am J Physiol Renal Physiol 2008; 294: F890-F899.
Carattino MD, Liu W, Hill W, Satlin LM, Kleyman TR. Lack of a role of membrane-protein interactions in flow-dependent activation of ENaC. American Journal of Physiology - Renal Physiology 2007; 293: F316-F324.
Liu W, Morimoto T, Woda C, Kleyman TR, Satlin LM. Ca2-dependence of flow-stimulation of K secretion in the mammalian collecting duct. American Journal of Physiology - Renal Physiology 2007; 293: F227-F235.
Wei Y, Zavilowitz B, Satlin LM, Wang W. Angiotensin II inhabits the ROMK-like small conductance K channel in renal cortical collecting duct during dietary potassium restriction. J Biol Chem 2007; 282: 6455-6462.
Satlin LM, Carattino M, Liu W, Kleyman TR. Regulation of cation transport in the distal nephron by mechanical forces. American Journal of Physiolocy 2006; 291: F923-F931.
Morimoto T, Liu W, Woda C, Carattino MS, Wei Y, Hughey RP, Apodaca G, Satlin* LM, Kleyman TR. Mechanism underlying flow-stimulation of Na absorption in the mammalian collecting duct (* corresponding author). American Journal of Physiology 2006; 291: F663-F669.
Najjar F, Zhou H, Morimoto T, Satlin LM, Li HS, Liu W, Kleyman TR, Bruns JB. Dietary K+ regulates apical membrane expression of maxi-K channels in rabbit cortical collecting dust. American Journal of Physiology - Renal Physiology 2005; 289: 922-932.
Woda CB, Bragin A, Kleyman TR, Satlin LM. Flow-dependent K+ secretion in the cortical collecting duct is mediated by a maxi-K channel. American journal of physiology. Renal physiology 2001 May; 280(5).
Satlin LM, Sheng S, Woda CB, Kleyman TR. Epithelial Na(+) channels are regulated by flow. American journal of physiology. Renal physiology 2001 Jun; 280(6).
Woda CB, Miyawaki N, Ramalakshmi S, Ramkumar M, Rojas R, Zavilowitz B, Kleyman TR, Satlin LM. Ontogeny of flow-stimulated potassium secretion in rabbit cortical collecting duct: functional and molecular aspects. American journal of physiology. Renal physiology 2003 Oct; 285(4).
Liu W, Xu S, Woda C, Kim P, Weinbaum S, Satlin LM. Effect of flow and stretch on the [Ca2+]i response of principal and intercalated cells in cortical collecting duct. American journal of physiology. Renal physiology 2003 Nov; 285(5).
Liu W, Wei Y, Sun P, Wang WH, Kleyman TR, Satlin LM. Mechanoregulation of BK channel activity in the mammalian cortical collecting duct: role of protein kinases A and C. American journal of physiology. Renal physiology 2009 Oct; 297(4).
Weinbaum S, Duan Y, Satlin LM, Wang T, Weinstein AM. Mechanotransduction in the renal tubule. American journal of physiology. Renal physiology 2010 Dec; 299(6).
Carrisoza-Gaytán R, Rangel C, Salvador C, Saldaña-Meyer R, Escalona C, Satlin LM, Liu W, Zavilowitz B, Trujillo J, Bobadilla NA, Escobar LI. The hyperpolarization-activated cyclic nucleotide-gated HCN2 channel transports ammonium in the distal nephron. Kidney international 2011 Oct; 80(8).
Liu W, Schreck C, Coleman RA, Wade JB, Hernandez Y, Zavilowitz B, Warth R, Kleyman TR, Satlin LM. Role of NKCC in BK channel-mediated net K⁺ secretion in the CCD. American journal of physiology. Renal physiology 2011 Nov; 301(5).
Liu W, Pastor-Soler NM, Schreck C, Zavilowitz B, Kleyman TR, Satlin LM. Luminal flow modulates H+-ATPase activity in the cortical collecting duct (CCD). American journal of physiology. Renal physiology 2012 Jan; 302(1).
Carrisoza-Gaytán R, Rangel C, Salvador C, Saldaña-Meyer R, Escalona C, Satlin LM, Liu W, Zavilowitz B, Trujillo J, Bobadilla NA, Escobar LI. The hyperpolarization-activated cyclic nucleotide-gated HCN2 channel transports ammonium in the distal nephron. Kidney international 2011 Oct; 80(8).
Industry Relationships
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Dr. Satlin did not report having any of the following types of financial relationships with industry during 2012 and/or 2013: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.
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