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Manish Arora

  • ASSOCIATE PROFESSOR Preventive Medicine
  • ASSOCIATE PROFESSOR (PENDING) Dentistry
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Biography

    Manish Arora, B.D.S., M.P.H., Ph.D., is the Director of Exposure Biology at the Senator Frank Lautenberg Environmental Health Sciences Laboratory in the Department of Preventive Medicine. Dr. Arora is an environmental epidemiologist and exposure biologist. He graduated with a Ph.D. from the University of Sydney in 2006, and undertook postgraduate fellowship training at the Harvard School of Public Health. Dr. Arora’s research focuses on effects of prenatal and early childhood chemical exposures on life-long health trajectories. He is known for his work on biomarkers that utilize human deciduous and permanent teeth to reconstruct the timing of exposure to various harmful chemicals and essential nutrients. His methods are being applied to the study of outcomes that are national health priorities, including autism and children’s neurodevelopment. Dr. Arora has also undertaken research on the intersection of oral and systemic health with the environment. His work supports shared genetic risk factors between periodontal disease and various cancers (pancreatic, colorectal, and prostate cancers). He has also reported increased risk of periodontal disease and dental caries in those exposed to environmental metal toxicants.

Awards

  • 2015 -
    Fellowship of the International College of Dentists

  • 2014 -
    $1.5 milllion New Innovator Award
    National Institutes of Environmental Health Sciences

  • 2005 -
    IADR/Hatton Award

Publications

Austin C, Smith TM, Bradman A, Hinde K, Joannes-Boyau R, Bishop D, Hare DJ, Doble P, Eskenazi B, Arora M. Barium distributions in teeth reveal early-life dietary transitions in primates. Nature 2013 Jun; 498(7453): 216-9.

Arora M, Weuve J, Fall K, Pedersen NL, Mucci LA. An exploration of shared genetic risk factors between periodontal disease and cancers: a prospective co-twin study. American Journal of Epidemiology 2010 Jan; 171(2): 253-9.

Arora M, Weuve J, Schwartz J, Wright RO. Association of environmental cadmium exposure with periodontal disease in U.S. adults. Environmental Health Perspectives 2009 May; 117(5): 739-44.

Andra SS, Austin C, Wright RO, Arora M. Reconstructing pre-natal and early childhood exposure to multi-class organic chemicals using teeth: Towards a retrospective temporal exposome. Environment international 2015 Jun; 83.

Hare DJ, Arora M, Jenkins NL, Finkelstein DI, Doble PA, Bush AI. Is early-life iron exposure critical in neurodegeneration?. Nature reviews Neurology 2015 Jun;.

Andra SS, Austin C, Wright RO, Arora M. Reconstructing pre-natal and early childhood exposure to multi-class organic chemicals using teeth: Towards a retrospective temporal exposome. Environment International 2015 Jun; 83.

Andra SS, Austin C, Arora M. Tooth matrix analysis for biomonitoring of organic chemical exposure: Current status, challenges, and opportunities. Environmental research 2015 Jul; 142.

Gunier RB, Arora M, Jerrett M, Bradman A, Harley KG, Mora AM, Kogut K, Hubbard A, Austin C, Holland N, Eskenazi B. Manganese in teeth and neurodevelopment in young Mexican-American children. Environmental research 2015 Sep; 142.

Hare DJ, Arora M, Jenkins NL, Finkelstein DI, Doble PA, Bush AI. Is early-life iron exposure critical in neurodegeneration?. Nature reviews. Neurology 2015 Sep; 11(9).

Andra SS, Charisiadis P, Arora M, van Vliet-Ostaptchouk JV, Makris KC. Biomonitoring of human exposures to chlorinated derivatives and structural analogs of bisphenol A. Environment international 2015 Oct; 85.

Mora AM, Arora M, Harley KG, Kogut K, Parra K, Hernández-Bonilla D, Gunier RB, Bradman A, Smith DR, Eskenazi B. Prenatal and postnatal manganese teeth levels and neurodevelopment at 7, 9, and 10.5years in the CHAMACOS cohort. Environment international 2015 Nov; 84.

Austin C, Smith TM, Farahani RM, Hinde K, Carter EA, Lee J, Lay PA, Kennedy BJ, Sarrafpour B, Wright RJ, Wright RO, Arora M. Uncovering system-specific stress signatures in primate teeth with multimodal imaging. Scientific reports 2016 Jan; 6.

Austin C, Niedzwiecki MM, Arora M. Multielemental bioimaging of tissues in children's environmental health research. Current opinion in pediatrics 2016 Feb;.

Modabbernia A, Arora M, Reichenberg A. Environmental exposure to metals, neurodevelopment, and psychosis. Current opinion in pediatrics 2016 Feb;.

Andra SS, Austin C, Arora M. The tooth exposome in children's health research. Current opinion in pediatrics 2016 Feb;.

Niedzwiecki MM, Austin C, Remark R, Merad M, Gnjatic S, Estrada-Gutierrez G, Espejel-Nuñez A, Borboa-Olivares H, Guzman-Huerta M, Wright RJ, Wright RO, Arora M. A multimodal imaging workflow to visualize metal mixtures in the human placenta and explore colocalization with biological response markers. Metallomics : integrated biometal science 2016 Mar;.

Rezza A, Wang Z, Sennett R, Qiao W, Wang D, Heitman N, Mok KW, Clavel C, Yi R, Zandstra P, Ma'ayan A, Rendl M. Signaling Networks among Stem Cell Precursors, Transit-Amplifying Progenitors, and their Niche in Developing Hair Follicles. Cell reports 2016 Mar;.

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. Arora did not report having any of the following types of financial relationships with industry during 2015 and/or 2016: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.

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