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Neil Theise

  • PROFESSOR Pathology
  • PROFESSOR Medicine, Gastroenterology
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Certifications

  • American Board of Pathology

Education

  • Residency,
    Columbia Univ College of Physicians & Surgeons

  • Fellowship,
    Mt. Sinai Hosp. New York City

Biography

    Neil Theise, MD is a diagnostic liver pathologist, adult stem cell researcher, and complexity theorist in New York City, where he is Professor of Pathology and of Medicine at the Icahn School of Medicine at Mount Sinai and attending physician at the Mount Sinai Beth Israel Medical Center. He received his BA in Oriental Studies (Judaica/Hebraica) and a BAS in Computer Science from University of Pennsylvania before earning his MD from Columbia University. Dr. Theise has authored or co-authored chapters in every major text book of liver pathology including: “Liver and Gallbladder” in Robbins and Cotran Pathologic Basis of Disease, “Liver and Biliary Tree” in Robbins’ Basic Pathology, and “Viral hepatitis” in MacSween’s Pathology of the Liver. He is also co-editor and co-author of the recent 4th edition of the WHO Classification of Tumours of the Digestive System and author of the “Liver Cancer” chapter for the WHO’s World Cancer Report 2013. In 2010, in recognition of the aggregate of Dr. Theise's clinical, scientific, and philosophical work and accomplishments, he was awarded an honorary doctorate (“Doctoris Honoris Causa”) by the University of Bordeaux.

Awards

  • 2010 -
    Outstanding Research Mentor Award
    Beth Israel Medical Center Gastroenterology Fellows

  • 2009 -
    Inductee, Lindisfarne Fellowship

  • 2007 -
    Outstanding Research Mentor Award
    Beth Israel Medical Center Gastroenterology Fellows

  • 2007 -
    Scholar in Residence
    Asian Academy of Pathology Annual Meeting

  • 2007 -
    Nancy L. R. Bucher Annual Lecture
    Department of Pathology and Laboratory Medicine: Boston University

  • 2003 -
    Seventh James O. Gibson Visiting Professor of Pathology
    University of Hong Kong

  • 2002 -
    Teacher of the Year, Class of 2004

Publications

Michalopoulos GK, Grompe M, Theise ND. Assessing the potential of induced liver regeneration. Nature medicine 2013 Sep; 19(9).

Falkowski O, An HJ, Ianus IA, Chiriboga L, Yee H, West AB, Theise ND. Regeneration of hepatocyte 'buds' in cirrhosis from intrabiliary stem cells. Journal of hepatology 2003 Sep; 39(3).

Benias PC, Gopal K, Bodenheimer H, Theise ND. Hepatic expression of toll-like receptors 3, 4, and 9 in primary biliary cirrhosis and chronic hepatitis C. Clinics and research in hepatology and gastroenterology 2012 Oct; 36(5).

Khan FM, Komarla AR, Mendoza PG, Bodenheimer HC, Theise ND. Keratin 19 demonstration of canal of Hering loss in primary biliary cirrhosis: . Hepatology (Baltimore, Md.) 2013 Feb; 57(2).

Brody RI, Theise ND. An inflammatory proposal for hepatocarcinogenesis. Hepatology (Baltimore, Md.) 2012 Jul; 56(1).

Bushell WC, Theise ND. Toward a unified field of study: longevity, regeneration, and protection of health through meditation and related practices. Annals of the New York Academy of Sciences 2009 Aug; 1172.

Gouw AS, Clouston AD, Theise ND. Ductular reactions in human liver: diversity at the interface. Hepatology (Baltimore, Md.) 2011 Nov; 54(5).

Dollé L, Best J, Empsen C, Mei J, Van Rossen E, Roelandt P, Snykers S, Najimi M, Al Battah F, Theise ND, Streetz K, Sokal E, Leclercq IA, Verfaillie C, Rogiers V, Geerts A, van Grunsven LA. Successful isolation of liver progenitor cells by aldehyde dehydrogenase activity in naïve mice. Hepatology (Baltimore, Md.) 2012 Feb; 55(2).

Yoon SM, Gerasimidou D, Kuwahara R, Hytiroglou P, Yoo JE, Park YN, Theise ND. Epithelial cell adhesion molecule (EpCAM) marks hepatocytes newly derived from stem/progenitor cells in humans. Hepatology (Baltimore, Md.) 2011 Mar; 53(3).

Kuntsevich V, Bushell WC, Theise ND. Mechanisms of yogic practices in health, aging, and disease. The Mount Sinai journal of medicine, New York; 77(5).

Theise ND. Stem cell plasticity: recapping the decade, mapping the future. Experimental hematology 2010 Jul; 38(7).

Theise ND. Beyond cell doctrine: complexity theory informs alternate models of the body for cross-cultural dialogue. Annals of the New York Academy of Sciences 2009 Aug; 1172.

Bushell WC, Spector NH, Theise ND. From the global to the local: possible pathways for the transduction of Indo-Sino-Tibetan cognitive-behavioral practices into site-specific, tissue-regenerative effects. Annals of the New York Academy of Sciences 2009 Aug; 1172.

Hytiroglou P, Snover DC, Alves V, Balabaud C, Bhathal PS, Bioulac-Sage P, Crawford JM, Dhillon AP, Ferrell L, Guido M, Nakanuma Y, Paradis V, Quaglia A, Theise ND, Thung SN, Tsui WM, van Leeuwen DJ. Beyond . American journal of clinical pathology 2012 Jan; 137(1).

Pathologic diagnosis of early hepatocellular carcinoma: a report of the international consensus group for hepatocellular neoplasia. Hepatology (Baltimore, Md.) 2009 Feb; 49(2).

Kuwahara R, Kofman AV, Landis CS, Swenson ES, Barendswaard E, Theise ND. The hepatic stem cell niche: identification by label-retaining cell assay. Hepatology (Baltimore, Md.) 2008 Jun; 47(6).

Hytiroglou P, Park YN, Krinsky G, Theise ND. Hepatic precancerous lesions and small hepatocellular carcinoma. Gastroenterology clinics of North America 2007 Dec; 36(4).

Chamberlain J, Yamagami T, Colletti E, Theise ND, Desai J, Frias A, Pixley J, Zanjani ED, Porada CD, Almeida-Porada G. Efficient generation of human hepatocytes by the intrahepatic delivery of clonal human mesenchymal stem cells in fetal sheep. Hepatology (Baltimore, Md.) 2007 Dec; 46(6).

Theise ND, Kuwahara R. The tissue biology of ductular reactions in human chronic liver disease. Gastroenterology 2007 Jul; 133(1).

Theise ND. Liver biopsy assessment in chronic viral hepatitis: a personal, practical approach. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2007 Feb; 20 Suppl 1.

Cogle CR, Theise ND, Fu D, Ucar D, Lee S, Guthrie SM, Lonergan J, Rybka W, Krause DS, Scott EW. Bone marrow contributes to epithelial cancers in mice and humans as developmental mimicry. Stem cells (Dayton, Ohio) 2007 Aug; 25(8).

Park YN, Kojiro M, Di Tommaso L, Dhillon AP, Kondo F, Nakano M, Sakamoto M, Theise ND, Roncalli M. Ductular reaction is helpful in defining early stromal invasion, small hepatocellular carcinomas, and dysplastic nodules. Cancer 2007 Mar; 109(5).

Theise ND. Implications of 'postmodern biology' for pathology: the Cell Doctrine. Laboratory investigation; a journal of technical methods and pathology 2006 Apr; 86(4).

Theise ND. Gastrointestinal stem cells. III. Emergent themes of liver stem cell biology: niche, quiescence, self-renewal, and plasticity. American journal of physiology. Gastrointestinal and liver physiology 2006 Feb; 290(2).

Zander DS, Baz MA, Cogle CR, Visner GA, Theise ND, Crawford JM. Bone marrow-derived stem-cell repopulation contributes minimally to the Type II pneumocyte pool in transplanted human lungs. Transplantation 2005 Jul; 80(2).

Theise ND. Now you see it, now you don't. Nature 2005 Jun; 435(7046).

Kofman AV, Morgan G, Kirschenbaum A, Osbeck J, Hussain M, Swenson S, Theise ND. Dose- and time-dependent oval cell reaction in acetaminophen-induced murine liver injury. Hepatology (Baltimore, Md.) 2005 Jun; 41(6).

Roskams TA, Theise ND, Balabaud C, Bhagat G, Bhathal PS, Bioulac-Sage P, Brunt EM, Crawford JM, Crosby HA, Desmet V, Finegold MJ, Geller SA, Gouw AS, Hytiroglou P, Knisely AS, Kojiro M, Lefkowitch JH, Nakanuma Y, Olynyk JK, Park YN, Portmann B, Saxena R, Scheuer PJ, Strain AJ, Thung SN, Wanless IR, West AB. Nomenclature of the finer branches of the biliary tree: canals, ductules, and ductular reactions in human livers. Hepatology (Baltimore, Md.) 2004 Jun; 39(6).

Theise ND, Wilmut I. Cell plasticity: flexible arrangement. Nature 2003 Sep; 425(6953).

Theise ND, Dollé L, Kuwahara R. Low hepatocyte repopulation from stem cells: a matter of hepatobiliary linkage not massive production. Gastroenterology 2013 Jul; 145(1).

Ianus A, Holz GG, Theise ND, Hussain MA. In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. The Journal of clinical investigation 2003 Mar; 111(6).

Krause DS, Theise ND, Collector MI, Henegariu O, Hwang S, Gardner R, Neutzel S, Sharkis SJ. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 2001 May; 105(3).

Theise ND, Nimmakayalu M, Gardner R, Illei PB, Morgan G, Teperman L, Henegariu O, Krause DS. Liver from bone marrow in humans. Hepatology (Baltimore, Md.) 2000 Jul; 32(1).

Theise ND, Badve S, Saxena R, Henegariu O, Sell S, Crawford JM, Krause DS. Derivation of hepatocytes from bone marrow cells in mice after radiation-induced myeloablation. Hepatology (Baltimore, Md.) 2000 Jan; 31(1).

Theise ND, Saxena R, Portmann BC, Thung SN, Yee H, Chiriboga L, Kumar A, Crawford JM. The canals of Hering and hepatic stem cells in humans. Hepatology (Baltimore, Md.) 1999 Dec; 30(6).

Park SC, Nguyen NT, Eun JR, Zhang Y, Jung YJ, Tschudy-Seney B, Trotsyuk A, Lam A, Ramsamooj R, Zhang Y, Theise ND, Zern MA, Duan Y. Identification of cancer stem cell subpopulations of CD34(+) PLC/PRF/5 that result in three types of human liver carcinomas. Stem cells and development 2015 Apr; 24(8).

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. Theise did not report having any of the following types of financial relationships with industry during 2014 and/or 2015: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.

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