Photo of Nelly Andarawis-Puri

Nelly Andarawis-Puri

  • ASSISTANT PROFESSOR Orthopaedics
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Biography

    Dr. Andarawis-Puri is an Assistant Professor in the Leni and Peter W. May Department of Orthopaedics at the Icahn School of Medicine at Mount Sinai in New York City. She graduated from Columbia University with a B.S. in Biomedical Engineering, and then completed her Ph.D. from the University of Pennsylvania in Bioengineering, specializing in Biomechanics, with Dr. Louis Soslowsky as her graduate mentor. Following her graduate studies, Dr. Andarawis-Puri joined Dr. Evan Flatow for her post-doctoral training in the Department of Orthopaedics at Mount Sinai School of Medicine. Dr. Andarawis-Puri became independent faculty in the Orthopaedics department at Icahn School of Medicine in January 2012.

    Research

    Dr. Andarawis-Puri’s work in tendon research spans both basic science and translational applications. Much of her earlier work focused on healing of the tendon into the bone. Under the advisement of Dr. Louis Soslowsky at the University of Pennsylvania, her pre-doctoral work evaluated the mechanical environment in the rotator cuff associated with a single tendon tear. Human cadaveric shoulders were used to investigate whether mechanical compensation by a non-injured tendon exists to potentially shield an injured tendon from further injury. Using strain mapping and texture correlation algorithms, this work established that the injured supraspinatus tendon and the intact infraspinatus tendon mechanically interact such that conditions that increased strain in the supraspinatus tendon (pre-disposing it to further injury) also increased strain in the infraspinatus tendon. Subsequently, she joined Dr. Flatow at Mount Sinai for her postdoctoral training to gain experience in establishing in vivo animal models and investigate the molecular and histological component of tendon injury. Their in vivo rat patellar tendon model of fatigue damage accumulation allows rigorous investigation of mechanisms of tendon degeneration. During her postdoc, she identified mechanical parameters that can non-destructively serve as indices of the damage state of the tendon that are predictive of the molecular, mechanical and structural response of the fatigue damaged tendon, over time. Their data also showed that certain matrix remodeling proteins are upregulated 1 week post loading until a certain initial tendon elongation threshold was reached, after which they shutdown, potentially explaining the inability of tendon to effectively repair accumulated damage. Findings from her postdoctoral work in conjunction with data that suggests that tendon healing does not effectively restore native properties, motivated a shift in her research focus after her postdoctoral training to promoting regenerative healing (scar free and with restored native tissue properties) in adult lacerated tendons. The current focus of Dr. Andarawis-Puri’s work is to promote scarless repair in tendons that results in restoration of their native mechanical function. In addition, since compensation by other components of the joint can help protect the tendon from further injury, and allow for an environment that is more conducive to allow the injured tendon to heal, the effect of injury to one tendon on overall joint mechanics is also evaluated.

    Honors & Awards

    2010    Article featured on cover of the Journal Orthopaedic Research, volume 28, issue 7

    2007    Honorable Mention: Society of Women Engineers Poster Presentation Competition          

    2006    First Place: Penn Center for Musculoskeletal Disorders Scientific Symposium Poster Presentation Competition

    2006    Best Poster Invitation: 53rd Annual Meeting of the Orthopaedic Research Society


    Recent Publications

    1. Zgonis MH, Andarawis NA, and Soslowsky LJ. Mechanics and Healing of Rotator Cuff Injury. In Abrams JS and Bell RH (Eds), Rotator Cuff Surgery, Springer, 2008.

    2. Andarawis-Puri N, Ricchetti ET, Soslowsky LJ. Rotator Cuff Tendon Strain Correlates with Tear Propagation. Journal of Biomechanics. 2009 Jan 19; 42(2):158-163. PMID: 19064267.

    3. Andarawis-Puri N, Ricchetti ET, Soslowsky LJ. Interaction between the Supraspinatus and Infraspinatus Tendons: Effect of Anterior Supraspinatus Tendon Full Thickness Tears on Infraspinatus Tendon Strain. American Journal of Sports Medicine. 2009 Sep; 37(9):1831-1839. PMID: 19483078.

    4. Fung DT, Wang VM, Andarawis-Puri N, Basta-Pljakic J, Li Y, Laudier DM, Sun HB, Jepsen KJ, Schaffler MB, Flatow EL. Early Response to Tendon Fatigue Damage Accumulation in a Novel In Vivo Model. Journal of Biomechanics. 2010 Jan 19; 43(2):274-279.  PMID: 19939387.

    5. Andarawis-Puri N, Kuntz A, Kim SY, Soslowsky LJ. Effect of Anterior Supraspinatus Tendon Partial-Thickness Tears on Infraspinatus Tendon Strain Through a Range of Joint Rotation Angles. Journal of Shoulder and Elbow Surgery. 2010 June; 19(4):617-623. PMID: 20080051.

    6. Andarawis-Puri N, Kuntz AF, Ramsey ML, Soslowsky LJ. Effect of Glenohumeral Abduction Angle on the Mechanical Interaction between the Supraspinatus and Infraspinatus Tendons for the Intact, Partial-Thickness Torn, and Repaired Supraspinatus Tendon Conditions. Journal of Orthopaedic Research. 2010 July; 28(7):846-851. PMID: 20058264.

    7. Andarawis-Puri N, Kuntz AF, Jawad AF, Soslowsky LJ. Infraspinatus and Supraspinatus Tendon Strain Explained Using Multiple Regression Models. Annals of Biomedical Engineering. 2010 Sep; 38(9):2979-2987. PMID: 20458629.

    8. Sereysky JB, Andarawis-Puri N, Ros SJ, Jepsen KJ, Flatow EL. Automated Image Analysis Methodfor Quantifying Damage Accumulation in Tendon. Journal of Biomechanics. 2010 Sep 17; 43(13):2641-2644.

    9. Sun HB, Andarawis-Puri N, Li Y, Fung D, Lee JY, Wang VM, Basta-Pljakic J, Leong D, Sereysky JB, Ros SJ, Klug RA, Braman J, Schaffler MB, Jepsen KJ, Flatow EL. Cycle-Dependent Matrix Remodeling Gene Expression Response in Fatigue-Loaded Rat Patellar Tendons. Journal of Orthopaedic Research. 2010 Oct; 28(10):1380-1386. PMID: 20839322.

    10. Andarawis-Puri N, Kuntz AF, Ramsey ML, Soslowsky LJ. Effect of Supraspinatus Tendon Repair Technique on the Infraspinatus Tendon. Journal of Biomechanical Engineering. 2011; 133(3):031008. PMID: 21303184

    11. Andarawis-Puri N, Flatow EL. Tendon Fatigue in Response to Mechanical Loading [Special Issue]. The Journal of Musculoskeletal and Neuronal Interactions, Tendons: the connection between muscle and bone. 2011 Jun;11(2):106-14. PMID: 21625047.

    12. Andarawis-Puri N, Sereysky JB, Jepsen KJ, Flatow EL. The Relationships Between Cyclic Fatigue Loading, Changes In Initial Mechanical Properties, And The In Vivo Temporal Mechanical Response Of The Rat Patellar Tendon. Journal of Biomechanics. 2012 Jan;45(1):59-65. PMID: 22055428.

    13. Neviaser A, Andarawis-Puri N, Flatow EL. Basic Mechanisms Of Tendon Fatigue Damage. Journal of Shoulder and Elbow Surgery. 2012 Feb;21(2):158-63. PMID: 22244058.

    14. Sereysky JB, Andarawis-Puri N, Jepsen KJ, Flatow EL. Structural and Mechanical Effects of In Vivo Fatigue Damage Induction on Murine Tendon. Journal of Orthopaedic Research. In press. PMID: 22072573.

    15. Andarawis-Puri N, Sereysky JB, Sun HB, Jepsen KJ, Flatow EL. The Molecular Response Of The Patellar Tendon To Fatigue Loading Explained In The Context Of The Initial Induced Damage And Number Of Fatigue Loading Cycles. Journal of Orthopaedic Research. In Press. PMID: 22227881.

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. Andarawis-Puri did not report having any of the following types of financial relationships with industry during 2012 and/or 2013: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

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