Photo of Nelly Alia-Klein

Nelly Alia-Klein

  • ASSOCIATE PROFESSOR Psychiatry
  • ASSOCIATE PROFESSOR Neuroscience
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Biography

    On January 2, 2013, Dr. Alia-Klein was appointed Associate Professor of Psychiatry (primary) and Neuroscience (secondary) at the Icahn School of Medicine at Mount Sinai and co-chief of Neuropsychoimaging of Addiction and Related Conditions (NARC) research program.

    Prior to joining Mt. Sinai, Dr. Alia-Klein was Medical Scientist at Brookhaven National Laboratory in New York where she developed a program of study on aggression. She received her PhD from Columbia University in New York City. Dr. Alia-Klein is Principal Investigator on NIMH R01 and co-investigator on several grants from NIDA. As co-chief of NARC, Dr. Alia-Klein works on gene-brain-behavior modeling to predict anger and reactive aggression in clinical diagnoses as Intermittent Explosive Disorder. One of her goals is to further develop understanding and treatment of anger attacks in psychiatric disorders. She published on the neurochemistry modulating these behaviors and the reactivity interplay of prefrontal and subcortical brain regions during provocation or other challenge. Her tools probe select genotypes and their effects on brain function through application of MRI and PET technology. Other topics of study such as sex differences are also of interest, in particular as they affect anger disorders.

    In the News

    Nova Science Now, PBS series on the neurobiology of violent behavior, title: Can Science Stop Crime? (Aired 10/17/2012)
    http://www.pbs.org/wgbh/nova/tech/can-science-stop-crime.html
        
    PBS special After Newtown
    http://video.pbs.org/video/2320006234/

Publications

Alia-Klein N, Parvaz MA, Woicik PA, Konova AB, Maloney T, Shumay E, Wang R, Telang F, Biegon A, Wang G, Fowler JS, Tomasi D, Volkow ND, Goldstein RZ. Gene by Disease Interaction on Orbitofrontal Gray Matter in Cocaine Addiction. Arch Gen Psychiatry 2011; 68(3): 283-294.

Alia-Klein N, Goldstein RZ, Moeller SJ, Williams B, Craig IW, Telang F, Biegon A, Wang G, Fowler JS, Volkow ND. Neural Mechanisms of Anger Regulation as a Function of Genetic Risk for Violence. Emotion 2009; 9(3): 385-396.

Goldstein RZ, Alia-Klein N, Tomasi D, Carillo JH, Maloney T, Woicik PA, Wang RL, Telang F, Volkow ND. Anterior cingulate cortex hypoactivation to an emotionally salient task in cocaine addiction: brain-behavior dissociation. Proc Natl Acad Sci (PNAS) 2009; 106(23): 9453-9458.

Alia-Klein N, Kriplani A, Pradhan K, Ma J, Logan J, Williams B, Craig IW, Telang F, Tomasi D, Goldstein RZ, Wang G, Volkow ND, Fowler JS. The MAO A genotype does not modulate resting brain metabolism in adults. Psychiatry Research: Neuroimaging 2008; 164(1): 73-76.

Alia-Klein N, Goldstein RZ, Logan J, Tomasi D, Kriplani A, Telang F, Shumay E, Biegon A, Henn F, Wang G, Volkow ND, Fowler JS. Brain MAO A Activity Predicts Trait Aggression. Journal of Neuroscience 2008; 28(19): 5099-5104.

Fowler JS, Alia-Klein N, Kriplani A, Logan J, Williams B, Zhu W, Craig IW, Telang F, Goldstein R, Volkow ND, Vaska P, Wang G. Evidence that brain MAO A activity does not correspond to MAO A genotype in healthy male subjects. Biological Psychiatry 2007; 62: 355-358.

Alia-Klein N, Goldstein RZ, Tomasi D, Zhang L, Telang F, Wang G, Fowler JS, Volkow ND. What is in a word? No versus Yes differential activate the lateral orbitofrontal cortex. Emotion 2007; 73: 649-659.

Alia-Klein N, O'Rourke TM, Goldstein RZ, Malaspina D. Insight into illness and adherence to psychotropic medications are separately associated with violence severity in a forensic sample. Aggressive behavior; 33(1).

Goldstein RZ, Alia-Klein N, Tomasi D, Zhang L, Cottone LA, Maloney T, Telang F, Caparelli EC, Chang L, Ernst T, Samaras D, Squires NK, Volkow ND. Is decreased prefrontal cortical sensitivity to monetary reward associated with impaired motivation and self-control in cocaine addiction?. American Journal of Psychiatry 2007; 164: 43-51.

Goldstein RZ, Alia-Klein N, Leskovjan AC, Fowler JS, Wang GJ, Gur RC, Hitzemann R, Volkow ND. Anger and depression in cocaine addiction: association with the orbitofrontal cortex. Psychiatry research 2005 Jan; 138(1).

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. Alia-Klein did not report having any of the following types of financial relationships with industry during 2012 and/or 2013: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

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