- ADJUNCT ASSOCIATE PROFESSOR Otolaryngology
- Research Laboratory
Annenberg Building Room 20-55
Office Tel: (212) 241-9236
Office Fax: (212) 369-5701
Page: (917) 314-2656
Gannon PJ, Doyle WJ, Ganjian E, Marquez S, Gnoy A, Gabrielle HS, Lawson W. Maxillary sinus mucosal blood flow during nasal vs tracheal respiration. Arch Otolaryngol Head Neck Surg 1997 Dec; 123(12): 1336-40.
Gannon PJ, Holloway RL, Broadfield DC, Braun AR. Asymmetry of chimpanzee planum temporale: humanlike pattern of Wernicke's brain language area homolog. Science 1998 Jan 9; 279(5348): 220-2.
Gannon PJ, Costantino PD, Lueg EA, Chaplin JM, Brandwein MS, Passalaqua PJ, Fliegelman LJ, Laitman JT, Marquez S, Urken ML. Use of the peritracheal fold in the dog tracheal transplantation model. Arch Otolaryngol Head Neck Surg 1999 Sep; 125(9): 959-63.OBJECTIVE: To investigate the technical aspects of the canine model of human tracheal transplantation for potential application to reconstruction of extremely long tracheal defects (> 10 cm). DESIGN: In phase 1, long tracheal segments were skeletonized and pedicled with the thyroid glands, cranial thyroid arteries and veins, and internal jugular vein branches. The segments were elevated completely, attached to the vascular pedicle only, and replaced with primary tracheal anastomoses. In phase 2, long segments were elevated along with a diffuse soft tissue "blanket" that envelops the trachea and thyroid glands. Because this study was designed to primarily address, in situ, tracheal perfusion territories of a cranially located vascular pedicle, microvascular anastomoses were not conducted. SUBJECTS: Two small-bodied beagles (10-15 kg) and 5 large-bodied mixed-breed dogs (20-30 kg) were humanely killed 2 to 41 days after surgery, and anatomic and histological analyses were conducted. RESULTS: Unlike that of humans, the thyroid gland complex of dogs is not intimately associated with the trachea but is conjoined with a peritracheal soft tissue "fold." Within this fold, blood is transmitted to the trachea via a diffuse, segmental vascular plexus. In phase 1, pronounced tracheal necrosis occurred within 2 to 5 days. In phase 2, extremely long tracheal segments (10-12 cm), based only on a cranially located pedicle, were still viable at 2 to 6 weeks. CONCLUSIONS: Preservation of the "peritracheal fold" in the dog model of tracheal transplantation is critical to the onset and maintenance of vascular perfusion in a long tracheal segment. Furthermore, the use of large-bodied dogs is necessary to provide for a usable venous efflux component.
Gannon PJ, Kheck NM, Hof PR. Language Areas of the Hominoid Brain: A Dynamic Communicative Shift on the Upper East Side Planum. In: Gibson K, Falk D, editors. Evolutionary Anatomy of the Primate Cerebral Cortex. 1st ed. New York, Cambridge University Press; 2000. pp216-40.
Genden EM, Gannon PJ, Smith S, Keck N, Deftereos M, Urken ML. Microvascular transfer of long tracheal autograft segments in the canine model. Laryngoscope 2002 Mar; 112(3): 439-44.
Genden EM, Gannon PJ, Smith S, Deftereos M, Urken ML. Microvascular transplantation of tracheal allografts model in the canine. Ann Otol Rhinol Laryngol 2003 Apr; 112(4): 307-13.
Gannon PJ, Kheck NM, Braun AR, Holloway RL. Planum parietale of chimpanzees and orangutans: a comparative resonance of human-like planum temporale asymmetry. Anat Rec A Discov Mol Cell Evol Biol 2005 Nov; 287(1): 1128-41.
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