- INSTRUCTOR Medicine, Clinical Immunology
American Board of Allergy & Immunology
MD/PHD, Albert Einstein College of Medicine
Residency, Internal Medicine
Mount Sinai Hospital
Fellowship, Allergy & Immunology
Mount Sinai Hospital
Fellowship, Allergy & Immunology
Mount Sinai Hospital
- PJ Maglione, MD, PhD is a physician-scientist in the Division of Clinical Immunology of the Department of Medicine. His research efforts in the areas of primary antibody deficiency and B cell biology have been supported by the Thrasher Research Fund, Clinical Immunology Society, and Jeffrey Modell Foundation. Dr. Maglione is board-certified by the American Board of Internal Medicine and the American Board of Allergy and Immunology, sees patients at the clinical immunology faculty practice, and supervises a weekly teaching clinic with the fellows in Mount Sinai's Allergy/Immunology training program.
2013 - 2014
Senior Fellowship Award
Clinical Immunology Society
Clemens von Pirquet Award
American College of Allergy, Asthma, and Immunology
2012 - 2013
Early Career Award
Thrasher Research Fund
T-independent antibody responses against bacteria
Current vaccines against bacteria are limited by serotype specificity and lack of long-term efficacy. With expanding resistance against antibiotics, new strategies for augmenting antibacterial immunity are clearly needed. Using a "bedside-to-bench" research approach, Dr. Maglione is studying human primary immunodeficiencies that impair the ability to produce antibodies against bacteria in order to understand the biological determinants of successful immunity against these pathogens. The goal of this work is to translate new information about how humans make antibodies against bacteria into novel strategies for immune therapies and vaccines. Particular attention is paid to "T-independent" antibody responses, as they are quite potent against bacteria but have not been extensively studied outside of animal models.
Non-infectious complications of primary immunodeficiency
While susceptibility to infection is a hallmark of primary immunodeficiency, dysregulated immune function can occur, manifesting as autoimmunity, inflammatory disease, or malignancy. Dr. Maglione is exploring the clinical and immunological parameters that predispose certain patients to these non-infectious, but markedly deleterious, complications of primary immunodeficiency. He has a particular interest in studying interstitial lung disease and B cell lymphoproliferative complications occurring in common variable immunodeficiency, and is involved in clinical research studies exploring possible treatments. This work has the potential to elucidate the determinants of dysregulated B cell responses underlying many types of autoimmunity and maligancy.
Maglione PJ, Simchoni N, Cunningham-Rundles C. Toll-like receptor signaling in primary immune deficiencies. Annals of the New York Academy of Sciences 2015 Apr;.
Maglione PJ, Simchoni N, Black S, Radigan L, Overbey JR, Bagiella E, Bussel JB, Bossuyt X, Casanova JL, Meyts I, Cerutti A, Picard C, Cunningham-Rundles C. IRAK-4 and MyD88 deficiencies impair IgM responses against T-independent bacterial antigens. Blood 2014 Dec; 124(24).
Maglione PJ, Overbey JR, Radigan L, Bagiella E, Cunningham-Rundles C. Pulmonary radiologic findings in common variable immunodeficiency: clinical and immunological correlations. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2014 Oct; 113(4).
Maglione PJ, Ko HM, Beasley MB, Strauchen JA, Cunningham-Rundles C. Tertiary lymphoid neogenesis is a component of pulmonary lymphoid hyperplasia in patients with common variable immunodeficiency. The Journal of allergy and clinical immunology 2014 Feb; 133(2).
Cunningham-Rundles C, Maglione PJ. Common variable immunodeficiency. The Journal of allergy and clinical immunology 2012 May; 129(5).
Maglione PJ, Chan J. How B cells shape the immune response against Mycobacterium tuberculosis. European journal of immunology 2009 Mar; 39(3).
Maglione PJ, Xu J, Casadevall A, Chan J. Fc gamma receptors regulate immune activation and susceptibility during Mycobacterium tuberculosis infection. Journal of immunology (Baltimore, Md. : 1950) 2008 Mar; 180(5).
Maglione PJ, Xu J, Chan J. B cells moderate inflammatory progression and enhance bacterial containment upon pulmonary challenge with Mycobacterium tuberculosis. Journal of immunology (Baltimore, Md. : 1950) 2007 Jun; 178(11).
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Dr. Maglione did not report having any of the following types of financial relationships with industry during 2014 and/or 2015: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
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