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Paul Maglione

  • INSTRUCTOR Medicine, Clinical Immunology
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Specialty

Certifications

  • American Board of Internal Medicine

Education

  • MD/PHD, Albert Einstein College of Medicine

  • Residency, Internal Medicine
    Mount Sinai Hospital

  • Fellowship, Allergy & Immunology
    Mount Sinai Hospital

  • Fellowship, Allergy & Immunology
    Mount Sinai Hospital

Biography

    PJ Maglione, MD, PhD is a physician-scientist in the Division of Clinical Immunology of the Department of Medicine. His research efforts in the areas of primary antibody deficiency and B cell biology have been supported by the Thrasher Research Fund, Clinical Immunology Society, and Jeffrey Modell Foundation. Dr. Maglione sees patients at the clinical immunology faculty practice and supervises a weekly teaching clinic with the fellows in Mount Sinai's Allergy/Immunology training program.

Awards

  • 2013 - 2014
    Senior Fellowship Award
    Clinical Immunology Society

  • 2013 -
    Clemens von Pirquet Award
    American College of Allergy, Asthma, and Immunology

  • 2012 - 2013
    Early Career Award
    Thrasher Research Fund

Research


T-independent antibody responses against bacteria


Current vaccines against bacteria are limited by serotype specificity and lack of long-term efficacy. With expanding resistance against antibiotics, new strategies for augmenting antibacterial immunity are clearly needed. Using a "bedside-to-bench" research approach, Dr. Maglione is studying human primary immunodeficiencies that impair the ability to produce antibodies against bacteria in order to understand the biological determinants of successful immunity against these pathogens. The goal of this work is to translate new information about how humans make antibodies against bacteria into novel strategies for immune therapies and vaccines. Particular attention is paid to "T-independent" antibody responses, as they are quite potent against bacteria but have not been extensively studied outside of animal models.

Non-infectious complications of primary immunodeficiency


While susceptibility to infection is a hallmark of primary immunodeficiency, dysregulated immune function can occur, manifesting as autoimmunity, inflammatory disease, or malignancy. Dr. Maglione is exploring the clinical and immunological parameters that predispose certain patients to these non-infectious, but markedly deleterious, complications of primary immunodeficiency.  He has a particular interest in studying interstitial lung disease and B cell lymphoproliferative complications occurring in common variable immunodeficiency, and is involved in clinical research studies exploring possible treatments. This work has the potential to elucidate the determinants of dysregulated B cell responses underlying many types of autoimmunity and maligancy.

Publications

Maglione PJ, Simchoni N, Black S, Radigan L, Overbey JR, Bagiella E, Bussel JB, Bossuyt X, Casanova JL, Meyts I, Cerutti A, Picard C, Cunningham-Rundles C. IRAK-4- and MyD88- deficiencies impair IgM responses against T-independent bacterial antigens. Blood 2014 Oct;.

Maglione PJ, Overbey JR, Radigan L, Bagiella E, Cunningham-Rundles C. Pulmonary radiologic findings in common variable immunodeficiency: clinical and immunological correlations. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 2014 Oct; 113(4).

Maglione PJ, Ko HM, Beasley MB, Strauchen JA, Cunningham-Rundles C. Tertiary lymphoid neogenesis is a component of pulmonary lymphoid hyperplasia in patients with common variable immunodeficiency. The Journal of allergy and clinical immunology 2014 Feb; 133(2).

Cunningham-Rundles C, Maglione PJ. Common variable immunodeficiency. The Journal of allergy and clinical immunology 2012 May; 129(5).

Maglione PJ, Chan J. How B cells shape the immune response against Mycobacterium tuberculosis. European journal of immunology 2009 Mar; 39(3).

Maglione PJ, Xu J, Casadevall A, Chan J. Fc gamma receptors regulate immune activation and susceptibility during Mycobacterium tuberculosis infection. Journal of immunology (Baltimore, Md. : 1950) 2008 Mar; 180(5).

Maglione PJ, Xu J, Chan J. B cells moderate inflammatory progression and enhance bacterial containment upon pulmonary challenge with Mycobacterium tuberculosis. Journal of immunology (Baltimore, Md. : 1950) 2007 Jun; 178(11).

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr.Maglione is not currently required to report Industry relationships.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

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