- PROFESSOR & CHAIR Microbiology
- PROFESSOR Medicine, Infectious Diseases
Ph.D., University of Vienna
Elected Fellow of the American Academy of Arts and Sciences
Baylor College of Medicine
Sanofi–Institut Pasteur Award
Election to the Institute of Medicine of the National Academy of Sciences
European Virology Award (EVA)
European Society for Virology
The German Academy of Sciences Leopoldina
Robert Koch Prize
Austrian Academy of Sciences
National Academy of Sciences
ResearchThe Palese Laboratory focuses on fundamental questions concerning the genetic make-up and biology of viruses, as well as virus-host interactions. They use molecular biological techniques to understand how viruses replicate and how they interact with cells to cause disease in their hosts. Emphasis is on the study of RNA viruses, including influenza, paramyxo, and corona viruses. These are four major research directions in the laboratory at the present time: (1) by genetically changing influenza viruses via recombinant DNA techniques, they are studying viral genes and gene products to develop a universal influenza virus vaccine; (2) intracellular proteins are identified that interact with viral proteins, and the biological functions of these cellular proteins are studies; (3) attempts are made to develop broad spectrum antivirals and to identify their mechanisms of actions.
The Palese Laboratory is interested in training students and postdoctoral fellows who will become independent investigators in "molecular" studies of infectious viral diseases.
Heaton NS, Langlois RA, Sachs D, Lim JK, Palese P, tenOever BR. Long-term survival of influenza virus infected club cells drives immunopathology. The Journal of Experimental Medicine 2014 Aug; 211(9).
Ellebedy AH, Krammer F, Li GM, Miller MS, Chiu C, Wrammert J, Chang CY, Davis CW, McCausland M, Elbein R, Edupuganti S, Spearman P, Andrews SF, Wilson PC, García-Sastre A, Mulligan MJ, Mehta AK, Palese P, Ahmed R. Induction of broadly cross-reactive antibody responses to the influenza HA stem region following H5N1 vaccination in humans. Proceedings of the National Academy of Sciences of the United States of America 2014 Sep; 111(36).
Miller MS, Palese P. Peering into the crystal ball: influenza pandemics and vaccine efficacy. Cell 2014 Apr; 157(2).
DiLillo DJ, Tan GS, Palese P, Ravetch JV. Broadly neutralizing hemagglutinin stalk-specific antibodies require FcγR interactions for protection against influenza virus in vivo. Nature Medicine 2014 Feb; 20(2).
Krammer F, Palese P. Universal influenza virus vaccines: need for clinical trials. Nature Immunology 2014 Jan; 15(1).
Heaton NS, Sachs D, Chen CJ, Hai R, Palese P. Genome-wide mutagenesis of influenza virus reveals unique plasticity of the hemagglutinin and NS1 proteins. Proceedings of the National Academy of Sciences of the United States of America 2013 Dec; 110(50).
Margine I, Krammer F, Hai R, Heaton NS, Tan GS, Andrews SA, Runstadler JA, Wilson PC, Albrecht RA, García-Sastre A, Palese P. Hemagglutinin stalk-based universal vaccine constructs protect against group 2 influenza A viruses. Journal of Virology 2013 Oct; 87(19).
Martinez-Gil L, Alamares-Sapuay JG, Ramana Reddy MV, Goff PH, Premkumar Reddy E, Palese P. A small molecule multi-kinase inhibitor reduces influenza A virus replication by restricting viral RNA synthesis. Antiviral Research 2013 Oct; 100(1).
Chou YY, Heaton NS, Gao Q, Palese P, Singer RH, Singer R, Lionnet T. Colocalization of different influenza viral RNA segments in the cytoplasm before viral budding as shown by single-molecule sensitivity FISH analysis. PLoS Pathogens 2013; 9(5).
Pica N, Palese P. Toward a universal influenza virus vaccine: prospects and challenges. Annual Review of Medicine 2013; 64.
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Below are financial relationships with industry reported by Dr. Palese during 2013 and/or 2014. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
- Avimex; Farmak; Genentech, Inc.; Gilead Sciences, Inc.; MedImmune, LLC
Scientific Advisory Board:
- MedImmune, LLC
- Avimex; MedImmune, LLC
Equity (Stock or stock options valued at greater than 5% ownership of a publicly traded company or equity of any value in a privately held company)
- ContraFect Corporation; Vivaldi Biosciences Inc.
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.
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