Photo of Robert Phelps

Robert Phelps

  • PROFESSOR Dermatology
  • PROFESSOR Pathology
Print ProfilePrint Profile

Certifications

  • Clinical & Laboratory Dermatological Immunology

  • Dermatopathology

  • American Board of Dermatology

  • American Board of Dermatology

  • Anatomic Pathology

Education

  • MD, University of Pennsylvania

  • Residency, Pathology
    Bellevue Hospital

  • Residency, Dermatology
    Mount Sinai Hospital

  • Fellowship, Pathobiology
    National Institute of Health

  • Fellowship, Dermatology
    National Institute of Health

Biography

    Dr. Robert Phelps is Professor of Dermatology and Pathology and Director of the Dermatopathology Service at Mount Sinai Medical Center. Dr. Phelps is extensively involved in the teaching of medical students, residents, fellows and faculty and he has been with Mount Sinai since 1986. His research interests include experimental models of skin disease, cutaneous oncology, and environmental skin disease. Dr. Phelps is an avid reader and also enjoys outdoor activities.

Research

Dermatology; dermatopathology

Publications

Phelps R, Murai C, Saito S, Kasturi KN, Bona C . Effect of targeted mutation in collagen V alpha 2 gene on development of cutaneous hyperplasia in tight skin mice. Mol Med 1998 May; 4(5): 356-360.

Collagen V plays a major regulatory role in the formation of heterotypic fibers of the dermis and cartilaginous tissues as well as in the assembly of extracellular matrix. The pN/pN mouse, which is defective in collagen V alpha 2 gene, exhibits skeletal abnormalities, skin fragility, and alterations in the collagen fiber organization, whereas the TSK/+ mouse, which is defective in fibrillin-1, the major component of microfibrils present in the extracellular matrix, develops cutaneous hyperplasia and autoimmunity. We have studied the role of collagen V in the formation of heterotypic collagen fibers in F1 mice, which are obtained by breeding pN/pN with TSK/+ mice. Our results show that F1 progeny neither develop cutaneous hyperplasia nor produce anti-topoisomerase I autoantibodies, unlike TSK/+ mice. The diameter of the collagen fibrils in the skin is also comparable to that found in control mice. Thus, the phenotypic changes observed in the TSK mouse could be reversed by genetic complementation with a collagen V-defective mouse.

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Below are financial relationships with industry reported by Dr. Phelps during 2012 and/or 2013. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Consulting:

  • sanofi-aventis

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

Edit profile in Sinai Central

Address

Annenberg Building Room 308
1468 Madison Avenue
New York, NY 10029

Tel: 212-241-9148
Fax: 212-241-7832