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Sanjay Mathew

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    Dr. Mathew is Assistant Professor of Psychiatry at Mount Sinai School of Medicine, and an attending physician at the Mood and Anxiety Disorders Program (MAP). His primary areas of research include MRI and proton MRS in anxiety and mood disorders, and experimental therapeutic approaches across these conditions using novel pharmacotherapies and brain intervention techniques. He is the recipient of a Career Development Award from NIMH to study the neurochemistry of GAD, and in collaboration with Dr. Dikoma Shungu at Weill Medical College of Cornell University, has CFIDS Association grant funding to compare the neurochemistry of GAD patients with CFS patients. He has received numerous awards for his research, including the American College of Neuropsychopharmacology Memorial Travel Award, American Psychiatric Association Lilly Resident Research Award, the Anxiety Disorders Association of America Trainee Travel Award, and grants from the National Alliance for Research on Schizophrenia and Depression, and the American Foundation for Suicide Prevention. Dr. Mathew has also won several awards for his teaching, and currently serves as the course director for psychopharmacological teaching for PGY2-4 psychiatry residents at Mount Sinai. He completed his residency in psychiatry and postdoctoral research fellowship at Columbia University's College of Physicians and Surgeons, and medical school at Baylor College of Medicine in Houston, TX, his hometown.

    In The News
    Dr. Mathew discusses mood disorders in The Daily News feature The Daily Check Up. View the PDF.


Price RB, Shungu DC, Mao X, Nestadt P, Kelly C, Collins KA, Murrough J, Charney DS, Mathew SJ. Amino acid neurotransmitter concentrations in anterior cingulate and occipital cortex in symptomatic patients with major depression: relationship to treatment resistance. Biol Psychiatry;.

Mathew SJ, Charney DS. Publication bias and the efficacy of antidepressants. Am J Psychiatry ;.

Mathew SJ, Mao X, Keegan KA, Levine SM, Smith EP, Otcheretko V, Coplan JD, Shungu DC. Elevated Ventricular Lactate in Chronic Fatigue Syndrome: A Proton Magnetic Resonance Spectroscopic Imaging Study. NMR Biomed 2008 Oct 21; epub ahead of print.

Mathew SJ, Garakani A, Reinhard JF, Oshana S, Donahue S. Preliminary evidence of short-term efficacy of a novel, non-azapirone selective 1A agonist in generalized anxiety disorder. Clin Therapeutics 2008; 30(9): 1658-1666.

Mathew SJ, Manji HK. Novel drugs and therapeutic targets for severe mood disorders. Neuropsychopharmacology 2008; 33(9): 2080-2092.

Mathew SJ, Price RB, Mao X, Smith EP, Coplan JD, Charney DS, Shungu DC. Hippocampal N-Acetylaspartate Concentration and Response to Riluzole in Generalized Anxiety Disorder. Biol Psychiatry 2008; 63(9): 891-898.

Mathew SJ, Price RB, Charney DS. Recent advances in the neurobiology of anxiety disorders: implications for novel therapeutics. Am J Med Genetics Part C: Seminars in Med Genetics; 148C: 89-88.

Coplan JD, Mathew SJ, E. Decreased choline and creatine concentrations in centrum semiovale in patients with generalized anxiety disorder: relationship to IQ and early trauma. Psychiatry Research: Neuroimaging 2006; 147(1): 27-39.

Mathew SJ, Amiel JA, Coplan JD, Fitterling H, Sackeim HA, Gorman JM. Riluzole in generalized anxiety disorder . Am J Psychiatry 2005; 162: 2379-2381.

Mathew SJ, Shungu DC, Mao X, Smith EP, Perera GM, Kegeles LS, Perera T, Lisanby SH, Rosenblum LA, Gorman JM, Coplan JD. A magnetic resonance spectroscopic imaging study of adult nonhuman primates exposed to early-life stressors. Biol Psychiatry 2003; 54: 727-735.

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr.Mathew is not currently required to report Industry relationships.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.

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