- ASSOCIATE PROFESSOR Neurology
Ph.D., University of New South Wales, Australia University of Sydney
Specific Clinical/Research Interest:
posture and gait; vestibular system; effects of spaceflight; Parkinson's disease (locomotor assessment)
The Human Aerospace Laboratory is funded primarily by NASA and focuses on the effects of extended microgravity exposure on sensorimotor function. Current projects include simulation of the effects of spaceflight using Galvanic vestibular stimulation and assessment of shuttle pilot performance. In addition, we have adapted the technology developed for these NASA projects for use in ambulatory assessment of gait and freezing in Parkinson's disease (translation research funded by NIH/NINDS).
Summary of Research Studies:
My laboratory is funded primarily by NASA and focuses on the effects of microgravity exposure on sensorimotor function. We are currently working on two main projects: 1) head-eye coordination during simulated shuttle landings in the shuttle training simulator at NASA Ames Research Center, using Galvanic vestibular stimulation (GVS - transmastoidal electrical stimulation of primary vestibular afferents via surface electrodes) to simulate the sensorimotor deficits engendered by exposure to microgravity; 2) ambulatory assessment of gait and freezing in Parkinson's disease.
Moore ST, MacDougall HG, Lesceu X, Speyer JJ, Wuyts FL, Clark JB. Head-eye coordination during simulated orbiter landings. Aviat Space Environ Med 2008; 79: 888-898.
Moore ST, MacDougall HG, Ondo WG. Ambulatory monitoring of freezing of gait in Parkinson's disease. J Neurosci Meth 2008; 167: 340-348.
Moore ST, MacDougall HG, Gracies JM, Ondo WG. Locomotor response to levodopa in fluctuating Parkinson's disease. Exp Brain Res 2008; 184: 469-478.
Moore ST, MacDougall H, Gracies JM, Cohen H, Ondo W. Long-term monitoring of gait in Parkinson's disease. Gait Posture 2007; 26: 200-207.
Moore ST, MacDougall H, Peters BT, Bloomberg JJ, Curthoys IS, Cohen H. Modeling locomotor dysfunction following spaceflight with Galvanic vestibular stimulation. Exp Brain Res 2006; 174: 647-659.
MacDougall H, Moore ST, Curthoys IS, Black FO. Modeling postural instability with Galvanic vestibular stimulation. Exp Brain Res 2006; 172: 208-220.
MacDougall HG, Moore ST. Functional assessment of head-eye coordination during vehicle operation. Optom Vis Sci 2005; 82: 706-715.
MacDougall HG, Moore ST. Marching to the beat of the same drummer: the spontaneous tempo of human locomotion. J Appl Physiol 2005; 99: 1164-1173.
Moore ST, Cohen B, Raphan T, Berthoz A, Clement G. Spatial orientation of optokinetic nystagmus and ocular pursuit during orbital space flight. Exp Brain Res 2005; 160: 38-59.
Moore ST, Diedrich A, Biaggioni I, Kaufmann H, Raphan T, Cohen B. Artificial gravity: a possible countermeasure for post-flight orthostatic intolerance. Acta Astronaut 2005; 56: 867-876.
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Dr. Moore did not report having any of the following types of financial relationships with industry during 2012 and/or 2013: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
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