Talia H Swartz, MD, PhD
- ASSISTANT PROFESSOR | Medicine, Infectious Diseases
Research Topics:AIDS/HIV, Cellular Immunity, Cytokines, Imaging, Immunology, Infectious Disease, Inflammation, Membrane Proteins/Channels, Membranes, Mucosal Immunology, T Cells, Transporters, Virulence Genes, Viruses and Virology
My clinical training is in Infectious Diseases with a specific interest in HIV and my basic science interest is in the biology that underlies chronic HIV infection. HIV is an incurable disease and while antiretroviral therapy is effective at suppressive viremia, long term sequelae of inflammation account for premature aging, higher rates of cardiovascular disease, and neoplasms. My research seeks to identify novel mechanisms of HIV-associated inflammation through membrane signaling.
American Board of Internal Medicine
Multi-Disciplinary Training AreasImmunology [IMM], Microbiology [MIC]
MD, Mount Sinai School of Medicine
PhD, Mount Sinai School of Medicine
Residency, Internal Medicine, Mount Sinai Hospital
Fellowship, Infectious Disease, Mount Sinai Hospital
Junior Faculty Translational Collaborative Research Initiative Pilot Award
Young Investigator Award, Conference on Retroviruses and Opportunistic Infections
National Institutes of Health, Allergy and Infectious Diseases Mentored Career Award
American Heart Association Scientist Development Grant
2015 Burroughs Wellcome Travel Award to attend Association for Clinical and Translational Science (ACTS)/American Federation for Medical Research (AFMR)
Basic Science Research Award
Alpha Omega Alpha Post-Graduate Award
Basic Science Research Award
Young Investigator Award
Fellow Member of Alpha Omega Alpha
Housestaff Excellence in Teaching Award
HIV infection and purinergic signaling
I am interested in understanding the mechanisms that underlie chronic inflammation that causes morbidity and mortality in well-controlled HIV-infected patients. Our laboratory research focuses on the role of purinergic signaling that is required for HIV infection and may activate pro-inflammatory cytokine production. Please visit the Swartz Laboratory.
Morino M, Natsui S, Ono T, Swartz TH, Krulwich TA, Ito M. Single site mutations in the hetero-oligomeric Mrp antiporter from alkaliphilic Bacillus pseudofirmus OF4 that affect Na+/H+ antiport activity, sodium exclusion, individual Mrp protein levels, or Mrp complex formation. The Journal of biological chemistry 2010 Oct; 285(40).
Morino M, Natsui S, Swartz TH, Krulwich TA, Ito M. Single gene deletions of mrpA to mrpG and mrpE point mutations affect activity of the Mrp Na+/H+ antiporter of alkaliphilic Bacillus and formation of hetero-oligomeric Mrp complexes. Journal of bacteriology 2008 Jun; 190(12).
Swartz TH, Ito M, Ohira T, Natsui S, Hicks DB, Krulwich TA. Catalytic properties of Staphylococcus aureus and Bacillus members of the secondary cation/proton antiporter-3 (Mrp) family are revealed by an optimized assay in an Escherichia coli host. Journal of bacteriology 2007 Apr; 189(8).
Liu J, Xue Y, Wang Q, Wei Y, Swartz TH, Hicks DB, Ito M, Ma Y, Krulwich TA. The activity profile of the NhaD-type Na+(Li+)/H+ antiporter from the soda Lake Haloalkaliphile Alkalimonas amylolytica is adaptive for the extreme environment. Journal of bacteriology 2005 Nov; 187(22).
Swartz TH, Ikewada S, Ishikawa O, Ito M, Krulwich TA. The Mrp system: a giant among monovalent cation/proton antiporters?. Extremophiles : life under extreme conditions 2005 Oct; 9(5).
Swartz TH, Ito M, Hicks DB, Nuqui M, Guffanti AA, Krulwich TA. The Mrp Na+/H+ antiporter increases the activity of the malate:quinone oxidoreductase of an Escherichia coli respiratory mutant. Journal of bacteriology 2005 Jan; 187(1).
Swartz TH, Huprikar S, Labombardi V, Pinney S, Anyanwu A, Lee M, Patel G. Heart transplantation in a patient with heteroresistant vancomycin-intermediate Staphylococcus aureus ventricular assist device mediastinitis and bacteremia. Transplant infectious disease : an official journal of the Transplantation Society 2013 Oct; 15(5).
Swartz TH, Lin JJ. A clinical refresher course for medical scientist trainees. Medical teacher 2014 Jun; 36(6).