Thomas P Zwaka, MD, PhD
- INTERIM DIRECTOR, THE BLACK FAMILY STEM CELL INSTITUTE
- PROFESSOR | Cell, Developmental & Regenerative Biology
Research Topics:Apoptosis/Cell Death, Cell Biology, Developmental Biology, Embryology, Epigenetics, Gene Regulation, Gene Therapy, Stem Cells, Tissue Engineering, Transcription Factors, Transcriptional Activation and Repression
Multi-Disciplinary Training AreaDevelopmental and Stem Cell Biology [DSCB]
MD PhD, University of Ulm
Postdoctoral, University of Wisconsin, Madison
Pluripotency, Cellular Diversity, and Multicellularity
Pluripotent stem cells can regenerate any tissue in the body, but the ability to direct these versatile cells toward specific medical endpoints, such as tissue repair or replacement, has been slow to develop. Our research is expected to accelerate the use of pluripotent stem cells in humans with injury or disease in a controlled, robust and predictable manner.
Dejosez M, Ura H, Brandt VL, Zwaka TP. Safeguards for cell cooperation in mouse embryogenesis shown by genome-wide cheater screen. Science 2013 Sep; 341(6153).
Zwaka TP. Pluripotency network in embryonic stem cells: maybe Leibniz was right all along. Cell stem cell 2012 Oct; 11(4).
Dejosez M, Zwaka TP. Pluripotency and nuclear reprogramming. Annual review of biochemistry 2012; 81.
Chu LF, Surani MA, Jaenisch R, Zwaka TP. Blimp1 expression predicts embryonic stem cell development in vitro. Current biology : CB 2011 Oct; 21(20).
Zwaka TP. Stem cells: Troublesome memories. Nature 2010 Sep; 467(7313).
Dejosez M, Levine SS, Frampton GM, Whyte WA, Stratton SA, Barton MC, Gunaratne PH, Young RA, Zwaka TP. Ronin/Hcf-1 binds to a hyperconserved enhancer element and regulates genes involved in the growth of embryonic stem cells. Genes & development 2010 Jul; 24(14).
Zwaka TP. Ronin and caspases in embryonic stem cells: a new perspective on regulation of the pluripotent state. Cold Spring Harbor symposia on quantitative biology 2008; 73.
Dejosez M, Krumenacker JS, Zitur LJ, Passeri M, Chu LF, Songyang Z, Thomson JA, Zwaka TP. Ronin is essential for embryogenesis and the pluripotency of mouse embryonic stem cells. Cell 2008 Jun; 133(7).
Fujita J, Crane AM, Souza MK, Dejosez M, Kyba M, Flavell RA, Thomson JA, Zwaka TP. Caspase activity mediates the differentiation of embryonic stem cells. Cell stem cell 2008 Jun; 2(6).
Zwaka TP. Keeping the noise down in ES cells. Cell 2006 Dec; 127(7).