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Victor L. Friedrich

  • ASSOCIATE PROFESSOR Neuroscience
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Education

  • Ph.D., Harvard University

Research

Neuroglia and Neural Development

My research analyses the development of neuroglia and of myelin and explores\r\nthe potential of genetically modified, transplanted neuroglia for therapy\r\nof some CNS disorders.

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CNS-derived neuroglial cells -astrocytes and oligodendrocytes- arise\r\nfor the most part from mitotic progenitor cells generated near the ventricular\r\nzone. During development the progenitors spread throughout the surrounding\r\nbrain and spinal cord. We are studying both the origin and migratory behavior\r\nof neuroglial progenitors by transplanting transgenically marked CNS cell preparations into normal unmarked recipients at various developmental ages\r\nand determining the location and identity of cells derived from the transplants.

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These experiments reveal basic mechanisms of gliogenesis. In addition,\r\nneuroglial progenitors are susceptible to in vitro genetic engineering.\r\nSince they by their nature disperse during development neuroglial cells,\r\ngenetically modified for secretion and transplanted into diseased recipients,\r\nmight effectively deliver therapeutic substances such as growth factors\r\nor lysosomal enzymes throughout the CNS. In collaboration with other laboratories\r\nat Mount Sinai, we are examining the migration of transplanted neuroglia\r\nin mice with various CNS diseases. We will eventually test the therapeutic\r\npotential of engineered neuroglia, those mouse models with the aim of developing\r\ntherapeutic strategies for human disorders.

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Publications

Hardy RJ, Friedrich V. Progressive remodeling of the oligodendrocyte process arbor during myelinogenesis. Dev Neurosci 1996; 18(4): 243-54.

Gregory E, Tezapsidis N, Carter J, Shioi J, Bouras C, Li HC, Johnston JM, Efthimiopoulos S, Friedrich V, Robakis N. Identification and neuron specific expression of the S182/presenilin I protein in human and rodent brains. J Neurosci Res 1996 Aug 1; 45(3): 308-20.

Hardy RJ, Friedrich V. Oligodendrocyte progenitors are generated throughout the embryonic mouse brain, but differentiate in restricted foci. Development 1996 Jul; 122(7): 2059-69.

Miranda SR, Erlich S, Visser JV, Gatt S, Dagan A, Friedrich V, Schuchman E. Bone Marrow Transplantation in Acid Sphingomyelinase-Deficient Mice: Engraftment and Cell Migration Into the Brain as a Function of Radiation, Age, and Phenotype . Blood 1997 Jul 1; 90(1): 444-452.

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.

Dr. Friedrich did not report having any of the following types of financial relationships with industry during 2012 and/or 2013: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website at http://icahn.mssm.edu/about-us/services-and-resources/faculty-resources/handbooks-and-policies/faculty-handbook. Patients may wish to ask their physician about the activities they perform for companies.

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