Job description: Postdoctoral fellow and Research Scientist positions are available in our lab (80% computation + 20% wet). We emphasize biological and biomedical impacts in the design of computational, experimental, statistical and integrative methods. Successful candidates will have unique opportunities to i) build on our unique expertise and momentum of epigenomics, and a strong network of collaborators, ii) synergize effective computational design with innovative experimental design, iii) take the lead role in multiple projects on the innovative use of third-generation sequencing and systems biology to better understand basic biology (bacteria, lower eukaryotes and mammals), human diseases and personalized medicine. Compensations are highly competitive. All employees are eligible for medical, dental, and health insurance. Subsidized housing is available for postdoctoral fellows.
Research problem: Although cytosine methylation has been almost exclusively studied as the DNA methylation in human, methylation (as well as other forms of DNA modifications) of other nucleotides also exists across all kingdoms of life. Recent work by us and others discovered that 6mA has significant functional roles in the regulation of core biological processes (e.g. cell cycle, gene expression, DNA repair etc.) in both prokaryotes and eukaryotes. The research goal and focus of our lab is to explore this young and promising field of 6mA epigenomes, discover other novel types of DNA modifications, their relationship to well-studied DNA/histone modifications, and make fundamentally new discoveries of novel regulatory mechanisms in health and diseases.
Unique expertise: We pioneered the fast growing field of bacterial epigenomics, focusing on pathogens that cause infectious diseases and associated cancers (especially interested in multi-drug resistance and virulence). We are expanding our expertise towards underexplored types of epigenetic variations in eukaryotes. We have unique expertise in the use of third generation sequencing (single molecule real-time, ~20kbp read length, and the emerging nanopore technique) with advantages of detecting >20 different types of DNA modifications, single molecule-level epigenetic phasing, full-length gene isoforms, complex structural variations, beyond second-generation techniques, in prokaryotes and eukaryotes. We integrate third-generation and second-generation sequencing for functional/comparative epigenomics/genomics and transcriptomics.
Desired skills/experience: Interested? Excited? Join us to reveal the fascinating biology! Candidates with computational background are expected have solid computer programming and statistical skills. Candidates with biology background are expected have basic computer skills and a strong motivation to improve computational and statistical skills. Please send the following to email@example.com.
- CV with a list of publications
- PDF files for the papers that involve computational and statistical data analyses, in which you are first or co-first author
Lab website: Fang Lab