Adipocyte Biology and Inflammation
Adipocytes (fat cells) were long thought to be inert storage facilities for fuel, in the form of fat (triglycerides). It is now clear that this was naïve and inaccurate: adipocyes have an enormous range of metabolic activity, and can serve either to store excess fuel, or to burn it and remove it. They also secrete a large number of molecules (adipokines) that can impair insulin signaling in liver and muscle, and insulin secretion by pancreatic beta cells, and thereby lead to the features of metabolic syndrome and Type 2 diabetes. This is a “hot” field in diabetes and obesity, and Mount Sinai investigators are strong in this area. It is also an area in which the DOMI is interested in recruiting additional senior researchers.
Diabetes, Obesity and Metabolism Institute
Mount Sinai Health System
One Gustave L. Levy Place
New York, NY 10029