Fuel Metabolism, Signal Transduction
Types 1 and 2 diabetes, metabolic syndrome and obesity all have their origins - and ultimate cures - in properly regulated mitochondrial energy use, fat metabolism, and glucose metabolism. These in turn are controlled in the relevant organs - brain, liver, fat cells, skeletal muscle cells, and pancreatic beta cells - by growth factors and nutrients, which then transmit their signals to the nucleus and mitochondria via complex intracellular signaling networks. Understanding these in the organs listed above, their intracellular signaling and metabolic control, is essential to understanding how to prevent and cure diabetes. Fortunately, multiple investigators in the DOMI have world-class expertise in these inter-related areas.
Diabetes, Obesity and Metabolism Institute
Mount Sinai Health System
One Gustave L. Levy Place
New York, NY 10029