Chiara Giannarelli, MD, PhD
- ADJUNCT ASSOCIATE PROFESSOR | Medicine, Cardiology
Research Topics:
Atherosclerosis, Cardiovascular, Gene Expressions, Imaging, Immunology, Inflammation, Macrophage, Systems Biology, T CellsDr. Chiara Giannarelli received her MD the University of Pisa, Italy. She completed her training in Internal Medicine and received her PhD in pharmacological sciences and pathophysiological mechanisms of cardiovascular disease at the University of Pisa, Italy. After completing her research fellowship at the Icahn School of Medicine at Mount Sinai she was recruited as Instructor in 2012 and then promoted to Assistant Professor in 2013. Her current research focuses into the identification of new molecular targets responsible for phenotypic switch of atherosclerotic plaques towards and advanced phenotype. She is now conducting translational and patient-oriented research using a Systems Biology approach to define new mechanisms and molecular targets for plaque instability in human samples from patients with clinically stable and unstable carotid and coronary disease.
Education
MD, University of Pisa
PhD, University of Pisa (Dept. of Pharmacology)
Post-Doctoral Fellow, Mount Sinai School of Medicine
Residency, University of Pisa
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2017
The Role of P2X7 in HIV-Infected Individuals with Atherosclerotic Cardiovascular, Multidisciplinary Research Development Initiative -
2016
Dissecting the cellular and molecular immune interactions in human atherosclerosis -
2016
NETWORK-DRIVEN DRUG REPURPOSING APPROACHES TO TREAT CORONARY ARTERY DISEASE -
2015
Multidisciplinary Research Development Initiative -
2013
Career Development Award
Angiogenesis in Atherosclerosis
We investigate the contribution of circulating monocyte subsets as a source of a new isoform of tissue factor with angiogenic activity to the growth of intimal neovessel in atherosclerosis as a potential mechanism of lesion instability culminating in the onset of ischemic cardiovascular events (i.e. stroke and myocardial infarction).
Immunity and Cardiovascular Disease
We study the contribution of inflammatory cells infiltrating the atherosclerotic arterial wall to the progression of the disease: identification of the cellular and molecular immune interactions that occur in the atherosclerotic plaque