Dara L Dickstein, PhD
- ADJUNCT ASSISTANT PROFESSOR | Neuroscience
Research Topics:Aging, Alzheimer's Disease, Blood-Brain Barrier, Cancer, Synapses, Transgenic Mice
Dr. Dickstein is currently an Assistant Professor in the Department of Neuroscience at Mount Sinai School of Medicine. Her educational background is in molecular genetics and immunology. Her PhD work was focused on the role of inflammation in Alzheimer’s disease (AD) pathogenesis and utilized transgenic animal models along with various biochemical and anatomical techniques. Dr. Dickstein continued in the field of AD in her postdoctoral fellowship, exploring the structural changes in neurons and synapses with disease progression. Currently, Dr. Dickstein's research is directed towards the study of selective neuronal vulnerability in ageing, dementia, and other neurodegenerative disorders using classical neuropathological as well as modern quantitative methods. Dr. Dickstein has established much national and international collaboration, and has become an expert in the techniques of intracellular injections, fluorescence quantification, confocal and electron microscopy. Dr. Dickstein is a co-PL in the Alzheimer’s Disease Research Center at Mount Sinai and a member of the Computational Neurobiology and Imaging Center (CNIC) at Mount Sinai. As a member of CNIC, she has contributed to the creation of an automated quantitative software tool (NeuronStudio) that enables accurate 3D analysis of individual neurons in the brain at very high resolution.
Multi-Disciplinary Training AreasNeuroscience [NEU], Pharmacology and Therapeutics Discovery [PTD]
PhD, University of British Columbia
The Microcirculatory Society Wiederhelm Award
Neurobiology of Ageing and Neurodegeneration
Research in the Dickstein lab focuses on the structural changes on neurons with ageing and disease. Our main research interests focus on Alzheimer’s disease and Parkinson’s disease, specifically targeting cells of the hippocampus and prefrontal cortex, areas crucial for cognition. We also investigate the effects of cancers and chemotherapy on neuronal and synapse integrity. We use a combination of transgenic mouse models, neuroanatomy, and confocal and electron microscopy to analyze the changes that neurons and synapses undergo during disease.