Evren U Azeloglu, PhD
- ASSISTANT PROFESSOR | Medicine, Nephrology
Research Topics:Biomechanics/Bioengineering, Biophysics, Cardiovascular, Computational Biology, Cytoskeleton, Kidney, Mathematical Modeling of Biomedical Systems, Mathematical and Computational Biology, Nanotechnology, Signal Transduction, Systems Biology, Tissue Engineering
Dr. Azeloglu is an Assistant Professor of Medicine in the Division of Nephrology with a secondary appointment in the Department of Pharmacological Sciences. He received his B.E. in Mechanical Engineering and M.S. in Biomedical Engineering from State University of New York at Stony Brook. He completed his Ph.D. in Biomedical Engineering from Columbia University in the City of New York and a postdoctoral fellowship in Department of Pharmacology and Systems Therapeutics in Icahn School of Medicine at Mount Sinai. He was awarded the Yuen-huo Hung & Chao-chin Huang Award from Columbia University and a Howard Hughes Medical Institute fellowship from the Life Science Research Foundation. His research focuses on cell and tissue biomechanics, mechanobiological signaling, systems pharmacology and tissue engineering.
Multi-Disciplinary Training AreaPharmacology and Therapeutics Discovery [PTD]
BE, Stony Brook University
MS, Stony Brook University
PhD, Columbia University
Howard Hughes Medical Institute Fellowship
Yuen-huo Hung & Chao-chin Huang Award (2009)
Stony Wold Herbert Fellowship
Our main goal at the Systems Bioengineering Lab is to understand cellular decision-making capabilities related to biomechanical and electrochemical signal processing. We employ multiscale experimental and computational techniques as well as microfabrication and tissue engineering methods to study cell signaling, biomechanics, tissue function and regeneration using cardiovascular and renal model systems. We also use multi-platform omics technologies and network analyses for identification of key information processing hubs and regulatory motifs that can be used as therapeutic targets in drug development for complex diseases such as hypertension, diabetic nephropathy and heart failure. See Azeloglu Lab website for more details.
Ron A, Azeloglu EU, Calizo RC, Hu M, Bhattacharya S, Chen Y, Jayaraman G, Lee S, Neves-Zaph SR, Li H, Gordon RE, He JC, Hone JC, Iyengar R. Cell shape information is transduced through tension-independent mechanisms. Nature communications 2017 Dec; 8(1).
Azeloglu EU, Hardy SV, Eungdamrong NJ, Chen Y, Jayaraman G, Chuang PY, Fang W, Xiong H, Neves SR, Jain MR, Li H, Ma'ayan A, Gordon RE, He JC, Iyengar R. Interconnected network motifs control podocyte morphology and kidney function. Science signaling 2014 Feb; 7(311).
Zhao S, Nishimura T, Chen Y, Azeloglu EU, Gottesman O, Giannarelli C, Zafar MU, Benard L, Badimon JJ, Hajjar RJ, Goldfarb J, Iyengar R. Systems pharmacology of adverse event mitigation by drug combinations. Science translational medicine 2013 Oct; 5(206).
Rangamani P, Lipshtat A, Azeloglu EU, Calizo RC, Hu M, Ghassemi S, Hone J, Scarlata S, Neves SR, Iyengar R. Decoding information in cell shape. Cell 2013 Sep; 154(6).
Azeloglu EU, Costa KD. Atomic force microscopy in mechanobiology: measuring microelastic heterogeneity of living cells. Methods in molecular biology (Clifton, N.J.) 2011; 736.
Azeloglu EU, Costa KD. Cross-bridge cycling gives rise to spatiotemporal heterogeneity of dynamic subcellular mechanics in cardiac myocytes probed with atomic force microscopy. American journal of physiology. Heart and circulatory physiology 2010 Mar; 298(3).
Azeloglu EU, Albro MB, Thimmappa VA, Ateshian GA, Costa KD. Heterogeneous transmural proteoglycan distribution provides a mechanism for regulating residual stresses in the aorta. American journal of physiology. Heart and circulatory physiology 2008 Mar; 294(3).