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Filip Swirski, PhD
img_Filip Swirski
PROFESSOR | Medicine, Cardiology
PROFESSOR | Diagnostic, Molecular and Interventional Radiology
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Research Topics
Alzheimer's Disease, Autoimmunity, B Cells, Blood, Brain, Cardiac Arrest and Resuscitation, Cardiovascular, Cellular Immunity, Chemokines, Chemotaxis, Cytokines, Dendritic Cells, Endocrinology, Hematopoiesis, Immunology, Inflammation, Lung, Lymphocytes, Macrophage, Microglia, Pathology, Sleep Medicine, Stem Cells, Stress, Systems Biology, T Cells, Transgenic Mice, Viruses and Virology
Multi-Disciplinary Training Area
Immunology [IMM], Microbiology [MIC], Neuroscience [NEU]
Systemic Inflammatory Networks and Inter-Organ Communication
Systemic inflammatory networks connect various cardiovascular and metabolic processes. I showed that the spleen produces monocytes by extramedullary hematopoiesis. I provided evidence for the relative contribution of monocyte recruitment and macrophage proliferation atherosclerosis. I identified an on-demand mechanism by which transient monocyte-derived macrophages dispose of erythrocytes and recycle iron. I identified a population of intraepithelial T cells that modulate dietary metabolism and contribute to cardiovascular disease.
Hematopoiesis and Growth Factors
Survival, proliferation, and differentiation of hematopoietic cells it tightly controlled by various cell-specific factors. I discovered a GM-CSF-producing B cell that protect against sepsis and pneumonia. I showed that the growth factor IL-3 aggravates sepsis by eliciting the cytokine storm. I defined a critical role for IL-3 in myocarditis. I demonstrated that T cell output in the thymus relies on liver X receptors.
Monocytes and Macrophages in Cardiovascular Disease
A major long-standing focus is to understand how monocytes and macrophages participate in atherosclerosis and myocardial infarction. I showed that monocytes accumulate continuously in evolving atherosclerotic lesions. I linked atherosclerosis with blood monocytosis. I identified a biphasic monocyte-macrophage response that coordinates healing, and discovered a monocyte reservoir in the spleen. I showed that sleep protects against atherosclerosis by limiting monocyte production.

PhD, McMaster University

Harvard Medical School

2020

ESC William Harvey Lecture on Basic Science

European Society of Cardiology

2019

Tucker Collins Lecture

2018

Leaders in Cardiovascular Science Profile

Circulation Research

2017

Jeffrey M Hoeg Award for Basic Science and Clinical Research

2017

Established Investigator Award

AHA

2016

Patricia and Scott Eston MGH Research Scholar

2016

Martin Prize for Fundamental Research

2016

Outstanding Investigator Award

NIH

2005

Howard M. Goodman Fellowship

210
Publications

Selected Publications

Effects of lifestyle factors on leukocytes in cardiovascular health and disease. Henrike Janssen, Laura L. Koekkoek, Filip K. Swirski. Nature Reviews Cardiology

Circulating myeloid-derived MMP8 in stress susceptibility and depression. Flurin Cathomas, Hsiao Yun Lin, Kenny L. Chan, Long Li, Lyonna F. Parise, Johana Alvarez, Romain Durand-de Cuttoli, Antonio V. Aubry, Samer Muhareb, Fiona Desland, Yusuke Shimo, Aarthi Ramakrishnan, Molly Estill, Carmen Ferrer-Pérez, Eric M. Parise, C. Matthias Wilk, Manuella P. Kaster, Jun Wang, Allison Sowa, William G. Janssen, Sara Costi, Adeeb Rahman, Nicolas Fernandez, Matthew Campbell, Filip K. Swirski, Eric J. Nestler, Li Shen, Miriam Merad, James W. Murrough, Scott J. Russo. Nature

Small-molecule CBP/p300 histone acetyltransferase inhibition mobilizes leukocytes from the bone marrow via the endocrine stress response. Nikolai P. Jaschke, Dorit Breining, Maura Hofmann, Sophie Pählig, Ulrike Baschant, Reinhard Oertel, Sofia Traikov, Tatyana Grinenko, Francesco Saettini, Andrea Biondi, Myrto Stylianou, Henrik Bringmann, Cuiling Zhang, Tomomi M. Yoshida, Heike Weidner, Wolfram C. Poller, Filip K. Swirski, Andy Göbel, Lorenz C. Hofbauer, Martina Rauner, Christoph Scheiermann, Andrew Wang, Tilman D. Rachner. Immunity

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Hess CSM Building Floor 7 Room 117

1470 Madison Ave

New York, NY 10029

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies, and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Dr. Swirski has not yet completed reporting of Industry relationships.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.