Ian S Maze, PhD
- PROFESSOR | Neuroscience
- PROFESSOR | Pharmacological Sciences
Research Topics:Addiction, Behavior, Chromatin, Depression, Drug Design and Discovery, Gene Expressions, Molecular Biology, Neuroscience
Ian S. Maze, Ph.D., is a chromatin biologist and neuroscientist investigating the complex interplay between chromatin regulatory mechanisms and neural plasticity in the mammalian central nervous system. His multidisciplinary and integrative research involves the use of biochemical, biophysical, physiological and behavioral analyses to explore the molecular underpinnings of neurodevelopmental and adult cognitive and psychiatric disorders. Dr. Maze is actively investigating the brains of rodents and postmortem humans, as well as human iPSC-derived neurons, to uncover chromatin-based mechanisms of neurological disease.
Multi-Disciplinary Training AreasDisease Mechanisms and Therapeutics (DMT), Neuroscience [NEU]
BS, The Ohio State University
PhD, Mount Sinai School of Medicine
Postdoctoral Fellowship, The Rockefeller University
McKnight Brain Disorder Award
Howard Hughes Medical Institute Investigator
Dr. Harold and Golden Laport Basic Research Award
Winner of Presidential Early Career Award for Scientists and Engineers (PECASE)
Basil O’Connor Award
Sloan Foundation Fellowship in Neuroscience
ACNP Travel Award
MQ: Transforming Mental Health Research Fellowship Award
NARSAD Young Investigator Award
Terry A. Krulwich Dissertation Award, Mount Sinai School of Medicine
The Maze laboratory is focused on understanding the role of chromatin dynamics, nucleosomal turnover and histone modifications in the central nervous system during periods of transcriptional, synaptic and behavioral plasticity. Extended emphasis is placed on investigating the functions of novel neuronal specific/enriched histone modifications and ‘reader’ proteins, as well as their role in developmental neurological disorders (e.g. Down syndrome, autism) and adult psychiatric illness (major depressive disorder, substance use disorder, etc.). Current projects include the utilization of chromatin biochemical techniques, genome-wide sequencing analyses and transgenic/viral vector-based gene modification systems to investigate novel chromatin-based mechanisms of monoaminergic dysfunction in disease. Search PubMed for publications
Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device and biotechnology companies to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their relationships with such companies.
Below are financial relationships with industry reported by Dr. Maze during 2022 and/or 2023. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.
Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.