Ivan Marazzi, PhD
- ASSOCIATE PROFESSOR | Microbiology
Research Topics:Epigenetics, Inflammation
The Marazzi lab studies epigenetic- and chromatin- mediated control of gene expression in the context of cellular response to pathogens or cellular differentiation. We are interested in proteins and non-coding RNA that play a role in controlling cell response and cell fate. We use biochemistry and next generation sequencing technique to understand molecular mechanisms and genome-wide effects of known and novel candidate genes.
Multi-Disciplinary Training AreasDevelopment, Regeneration, and Stem Cells [DRS], Microbiology [MIC]
PhD, Institute Research Biomedicine
Postdoctoral, Rockefeller University
Saccani S, Marazzi I, Beg AA, Natoli G, Dewell S, Albrecht RA, Seibert CW, Schaefer U, Jeffrey KL, Prinjha RK, Lee K, García-Sastre A, Roeder RG, Tarakhovsky A. Degradation of promoter-bound p65/RelA is essential for the prompt termination of the nuclear factor kappaB response. The Journal of experimental medicine 2004 Jul; 200(1).
Natoli G, Saccani S, Bosisio D, Marazzi I. Interactions of NF-kappaB with chromatin: the art of being at the right place at the right time. Nature immunology 2005 May; 6(5).
Bosisio D, Marazzi I, Agresti A, Shimizu N, Bianchi ME, Natoli G. A hyper-dynamic equilibrium between promoter-bound and nucleoplasmic dimers controls NF-kappaB-dependent gene activity. The EMBO journal 2006 Feb; 25(4).
Sampath SC, Marazzi I, Yap KL, Sampath SC, Krutchinsky AN, Mecklenbräuker I, Viale A, Rudensky E, Zhou MM, Chait BT, Tarakhovsky A. Methylation of a histone mimic within the histone methyltransferase G9a regulates protein complex assembly. Molecular cell 2007 Aug; 27(4).
Nicodeme E, Jeffrey KL, Schaefer U, Beinke S, Dewell S, Chung CW, Chandwani R, Marazzi I, Wilson P, Coste H, White J, Kirilovsky J, Rice CM, Lora JM, Prinjha RK, Lee K, Tarakhovsky A. Suppression of inflammation by a synthetic histone mimic. Nature 2010 Dec; 468(7327).
Marazzi I, Ho JS, Kim J, Manicassamy B, Dewell S, Albrecht RA, Seibert CW, Schaefer U, Jeffrey KL, Prinjha RK, Lee K, García-Sastre A, Roeder RG, Tarakhovsky A, Prinjha RK, Lee K, Tarakhovsky A. Suppression of the antiviral response by an influenza histone mimic. Nature 2012 Mar; 483(7390).