Jian Jin

Jian Jin, PhD

  • PROFESSOR | Oncological Sciences
  • PROFESSOR | Pharmacological Sciences

Research Topics:

Cancer, Chromatin, Drug Design and Discovery, Epigenetics, Membrane Proteins/Channels, Neuroscience, Structural Biology

Jian Jin, PhD, is the Mount Sinai Endowed Professor in Therapeutics Discovery, Director of the Mount Sinai Center for Therapeutics Discovery, and Co-Leader of the Cancer Clinical Investigation Program at The Tisch Cancer Institute.

Dr. Jin is an internationally recognized medicinal chemist with more than 20 years of experience in small-molecule drug discovery. His laboratory is a leader in developing novel small-molecule degraders using heterobifunctional technologies including the proteolysis targeting chimera (PROTAC) technology. Since 2014, Dr. Jin’s lab has generated numerous first-in-class degraders targeting oncogenic proteins and studied their anti-tumor activities. For example, they discovered first-in-class degraders of the lysine methyltransferase EZH2, a key oncogenic driver for breast cancer, prostate cancer, lymphoma, leukemia and several other cancers. Dr. Jin is an inventor of more than 50 U.S. patents and published international patent applications. As the Director of the Mount Sinai Center for Therapeutics Discovery, he leads Mount Sinai’s research effort on discovering innovative small-molecule therapeutics for the treatment of human diseases including cancer.

Dr. Jin has mentored more than 25 MD/PhD and PhD students and postdoctoral fellows in his lab. He has served as co-director of the Multidisciplinary Training Area in Pharmacology and Therapeutics Discovery for the Graduate School of biomedical sciences at Mount Sinai.

Dr. Jian Jin received a Bachelor of Science degree in chemistry from the University of Science and Technology of China in 1991 and a PhD in organic chemistry from the Pennsylvania State University in 1997. After completing post-doctoral training at the Ohio State University, Dr. Jin joined GlaxoSmithKline as a medicinal chemist. In 2008, he joined the Division of Chemical Biology and Medicinal Chemistry at the University of North Carolina at Chapel Hill as an associate professor; he also served as Associate Director of Medicinal Chemistry in the Center for Integrative Chemical Biology and Drug Discovery. Dr. Jin was recruited to the Icahn School of Medicine at Mount Sinai as a professor with tenure in 2014.
 

Lab website

Complete list of published work in PubMed

Google scholar citations
 

 

 

 

Multi-Disciplinary Training Area

Pharmacology and Therapeutics Discovery [PTD]

Education

BS, University of Science and Technology of China

PhD, Pennsylvania State University

Postdoc, Ohio State University