John O Mascarenhas, MD
- ASSOCIATE PROFESSOR | Medicine, Hematology and Medical Oncology
Specialties:Cancer (Oncology), Hematology-Oncology
Dr. John Mascarenhas is an Associate Professor of Medicine at the Icahn School of Medicine at Mount Sinai (ISMMS) and a member of the Tisch Cancer Institute. Dr. Mascarenhas is the Director of the Adult Leukemia Program and Leader of Clinical Investigation within the Myeloproliferative Disorders Program at Mount Sinai, under the direction of Dr. Ronald Hoffman. As a clinical investigator in malignant hematology with a focus in translational research involving myeloproliferative neoplasms (MPNs) and evolution to acute myeloid leukemia (AML), he is focused on the evaluation of rationale based novel therapies for patients with MPNs and AML. Dr. Mascarenhas is also the Principal Investigator (PI) of the clinical trials project within the National Cancer Institute sponsored Myeloproliferative Disorder Research Consortium (MPD-RC). He has served as PI or Study Chair of multiple investigator-initiated and industry-sponsored early and late phase clinical trials evaluating innovative approaches to the treatment of MPNs and AML. Additionally, he holds multiple administrative roles at Mount Sinai including Chair of the Leukemia Disease Management Team, Co-Chair of the Hematologic Malignancy Disease Focus Group, and full member of the Tisch Cancer Institute Protocol and Review Monitoring Committee.
Acute myeloid leukemia
Chronic myelogenous leukemia
Chronic neutrophilic leukemia
Chronic myelomonocytic leukemia
- Chronic Myelocytic Leukemia
- Myelodysplastic Syndromes
- Primary Polycythemia
MD, New York Medical College
Residency, Internal Medicine, Rhode Island Hospital
Fellowship, Hematology, Mount Sinai Hospital
Richard E. Rosenfeld Faculty Achievement Award
- A Randomized, Single-Blind, Multicenter Phase 2 Study to Evaluate the Activity of 2 Dose
You have been asked to take part in this study because you have been diagnosed with myelofibrosis and your cancer has returned after treatment with a Janus Kinase (JAK) Inhibitor. Myelofibrosis is a type of cancer that affects the production of blood cells.
- Combination Therapy of Ruxolitinib and Decitabine in patients with Myeloproliferative Neoplasms in Accelerated and Blast Phase Disease
The purpose of this phase I study is to test the safety and tolerability of ruxolitinib at different do...
- Phase I/II Study of Combination oral JAK2 tyrosine kinase inhibitor (JAK2-TKI) and Histone Deacetylase Inhibitor (HDACI) therapy in patients with Myelofibrosis
The purpose of this study is to find out if the drug combination of panobinostat and ruxolitinib is safe and has beneficial effects in people who have primary myelofibrosis (PMF), post-polycythemia vera myelofibrosis (PPV-MF) or post-essential thrombocythemia myelofibrosis (PE...
- A Phase 2 Pilot Trial of Ruxolitinib combined with Danazol for Patients with Primary Myelofibrosis (MF), Post Essential Thrombocythemia-Myelofibrosis (Post ET) and Post Polycythemia Vera Myelofibrosis (PV MF) Suffering from Anemia
The purpose of this study is to find out if the drug Ruxolitnib combined with Danazol is safe and has beneficial effects in people who are diagnosed with Primary Myelofibrosis (PMF) or Post-Essential Thromobocythemia Myelofibrosis (PET MF) or Post-Polycythemia Vera Myelofibros...
- A Phase 2, Open-Label, Prospective Study of PRM-151 in Subjects with Primary Myelofibrosis (PMF), Post-Polycythemia Vera MF (post-PV MF), or Post-Essential Thrombocythemia MF (post-ET MF)
The purpose of this study is to gather information on whether PRM-151 has an effect on your myelofibrosis (MF) disease, whether it is safe in patients wit...
- Open label study of single agent oral RG7388 in patients with polycythemia vera and essential thrombocythemia, with pilot feasibility study in combination with pegylated interferon alfa 2a
The research looks at two conditions, Essential Thrombocythemia (ET) and Polycythemia Vera (PV). ET causes people to produce too many blood cells called platelets and pV causes too many platelets and red blood cells to be made. Platelets are particles which circula...
- An Open-Label, Multiple Simon 2-Stage Study of INCB039110 Administered Orally to Subjects with Primary Myelofibrosis (PMF), Post Polycythemia Vera-Myelofibrosis (PPV-MF) or Post Essential Thrombocythemia-Myelofibrosis (PET-MF)
The purpose of this study is to evaluate the safety and effectiveness of an experimental drug called INCB039110. An experimental drug is not approved by the United States Food and Drug Administration (FDA) for use except in research studies. The purpose of this research study ...
Gowin K, Kosiorek H, Dueck A, Mascarenhas J, Hoffman R, Reeder C, Camoriano J, Tibes R, Gano K, Palmer J, Mesa R. Multicenter phase 2 study of combination therapy with ruxolitinib and danazol in patients with myelofibrosis. Leukemia research 2017 Sep; 60.
Choi DC, Tremblay D, Iancu-Rubin C, Mascarenhas J. Programmed cell death-1 pathway inhibition in myeloid malignancies: implications for myeloproliferative neoplasms. Annals of hematology 2017 Jun; 96(6).
Mascarenhas J, Sandy L, Lu M, Yoon J, Petersen B, Zhang D, Ye F, Newsom C, Najfeld V, Hochman T, Goldberg JD, Hoffman R. A phase II study of panobinostat in patients with primary myelofibrosis (PMF) and post-polycythemia vera/essential thrombocythemia myelofibrosis (post-PV/ET MF). Leukemia research 2017 Feb; 53.
Mascarenhas JO, Talpaz M, Gupta V, Foltz LM, Savona MR, Paquette R, Turner AR, Coughlin P, Winton E, Burn TC, O'Neill P, Clark J, Hunter D, Assad A, Hoffman R, Verstovsek S. Primary analysis of a phase II open-label trial of INCB039110, a selective JAK1 inhibitor, in patients with myelofibrosis. Haematologica 2017 02; 102(2).