Lisa M Satlin, MD
- PROFESSOR AND SYSTEM CHAIR | Pediatrics
- PROFESSOR | Medicine, Nephrology
Specialties:Pediatrics, Pediatric Nephrology and Hypertension
Research Topics:Biomechanics/Bioengineering, Cell Biology, Cellular Differentiation, Cytoskeleton, Developmental Biology, Electrophysiology, Epithelial Cells, Gene Expressions, Growth, Growth Factors and Receptors, Hormones, Imaging, Kidney, Knockout Mice, Membrane Proteins/Channels, Membranes, Phosphorylation, Protein Complexes, Protein Kinases, Protein Phosphatases, Protein Trafficking & Sorting, Signal Transduction, Trafficking, Transporters, Two-Photon Imaging
Lisa Satlin is the Herbert H. Lehman Professor of Pediatrics and Chair of the Department at the Icahn School of Medicine at Mount Sinai (ISMMS) and Mount Sinai Kravis Children's Hospital. She received her MD degree from Columbia University College of Physicians and Surgeons, and completed a residency in Pediatrics at the Babies Hospital of Columbia University and a Pediatric Nephrology Fellowship at the Albert Einstein College of Medicine. At the ISMMS, as Chief of the Division of Pediatric Nephrology (1997-2010), Dr. Satlin built an internationally respected academic division and an ACGME-accredited Pediatric Nephrology Fellowship training program, which has attracted both physician and research trainees interested in clinical nephrology and basic/translational research related to developmental nephrology, respectively. She continues to run an active NIH-supported laboratory, supported in part to serve as a national “Single Tubule Physiology Core” as part of an O’Brien Renal Research Center, focused on defining the mechanisms leading to the acquisition, maintenance and regulation of transepithelial transport in the renal collecting duct, the nephron segment responsible in the adult for the final regulation of salt and water homeostasis. Her research accomplishments have been recognized by her election to membership in the Society for Pediatric Research, the American Pediatric Society, and the Association of American Physicians.
Dr. Satlin has served as President of the American Society of Pediatric Nephrology and Councilor of the International Pediatric Nephrology Association. She completed two terms as Associate Editor of the American Journal of Physiology: Renal Physiology, and has participated in many study sections and grant-review groups for the NIH and the American Heart Association.
American Board of Pediatrics
- Electrolyte problems, acidosis
- Hypertension (high blood pressure)
Multi-Disciplinary Training AreaPharmacology and Therapeutics Discovery [PTD]
MD, Columbia Univ. Col. of Phy. & Surg.
Residency, Pediatrics, Columbia-Presbyterian Medical Ctr.
Fellowship, Nephrology, Albert Einstein College of Medicine
Selected as the Hans Ussing Lecturer, American Physiological Society, Annual Meeting of the Federation of American Societies for Experimental Biology
Jacobi Medallion Recipient
Recipient of the J. Lester Gabrilove Award
KUFA National Medal Award in Pediatric Nephrology
The focus of the Satlin lab is on defining the mechanisms leading to the acquisition, maintenance and regulation of transepithelial transport in the mammalian cortical collecting duct, a nephron segment responsible in the adult for the final renal regulation of total body potassium (K) and sodium (Na) homeostasis. Specifically, her lab continues to expand on two major discoveries: (1) unique developmental programs underlying the postnatal expression of ion channels responsible for Na absorption (ENaC) and K secretion (SK/ROMK and calcium/flow-activated BK channels) in this epithelium, thus establishing the physiological basis for total body Na and K retention required for somatic growth and maintenance of blood pressure, and (2) the role of variations in urinary flow rate (i.e., hydrodynamic forces) in mechanoregulation of renal epithelial ion channels in health and disease. As the lab serves as a national "Single Nephron Physiology" Core of an NIH-funded O'Brien Center for Kidney Research, techniques available to Core users include in vitro microperfusion of single nephron segments, fluorescent functional imaging of single cells in native tissue or cultured epithelia (for measurement of cell pH, calcium, K and Na), patch clamp studies of single cells for electrophysiologic analysis of channel activity, and molecular/biochemical techniques applied to single cells and tubules.