Lisa M Satlin, MD
- PROFESSOR AND SYSTEM CHAIR | Pediatrics
- PROFESSOR | Medicine, Nephrology
Specialties:Pediatrics, Pediatric Nephrology and Hypertension
Research Topics:Biomechanics/Bioengineering, Cell Biology, Cellular Differentiation, Cytoskeleton, Developmental Biology, Electrophysiology, Epithelial Cells, Gene Expressions, Growth, Growth Factors and Receptors, Hormones, Imaging, Kidney, Knockout Mice, Membrane Proteins/Channels, Membranes, Phosphorylation, Protein Complexes, Protein Kinases, Protein Phosphatases, Protein Trafficking & Sorting, Signal Transduction, Trafficking, Transporters, Two-Photon Imaging
Lisa M. Satlin, MD is the Herbert H. Lehman Professor of Pediatrics and Chair of the Jack and Lucy Clark Department of Pediatrics at the Icahn School of Medicine at Mount Sinai (ISMMS) and Pediatrician-in-Chief of the Mount Sinai Kravis Children's Hospital. She received her medical degree from Columbia University College of Physicians and Surgeons, and completed a residency in Pediatrics at the Babies Hospital of Columbia University and a Pediatric Nephrology Fellowship at the Albert Einstein College of Medicine. At the ISMMS, as Chief of the Division of Pediatric Nephrology (1997-2010), Dr. Satlin built an internationally respected academic division, which has attracted both physician and research trainees interested in clinical nephrology and basic/clinical/translational research related to developmental nephrology. She runs an active NIH-funded laboratory, supported in part to serve as a national “Single Tubule Physiology Core” as part of an O’Brien Renal Research Center, focused on defining the mechanisms leading to the acquisition, maintenance and regulation of ion transport in the renal collecting duct, the nephron segment responsible in the adult kidney for the final regulation of salt and water homeostasis. Her research accomplishments have been recognized by her election to membership in the Society for Pediatric Research, the American Pediatric Society, and the Association of American Physicians.
Dr. Satlin has served as President of the American Society of Pediatric Nephrology and Councilor of the International Pediatric Nephrology Association. She completed two terms as Associate Editor of the American Journal of Physiology: Renal Physiology, and has participated in many study sections and grant-review groups for the NIH and the American Heart Association.
American Board of Pediatrics
- Electrolyte problems, acidosis
- Hypertension (high blood pressure)
Multi-Disciplinary Training AreaPharmacology and Therapeutics Discovery [PTD]
MD, Columbia Univ. Col. of Phy. & Surg.
Residency, Pediatrics, Columbia-Presbyterian Medical Ctr.
Fellowship, Nephrology, Albert Einstein College of Medicine
Selected to deliver the 2018 Carl W. Gottschalk Distinguished Lectureship of the APS Renal Section
Selected as the Hans Ussing Lecturer, American Physiological Society, Annual Meeting of the Federation of American Societies for Experimental Biology
Jacobi Medallion Recipient
Recipient of the Barry M. Brenner Endowed Lectureship from the American Society of Nephrology
Recipient of the J. Lester Gabrilove Award
KUFA National Medal Award in Pediatric Nephrology
The focus of the Satlin lab is on defining the mechanisms leading to the acquisition, maintenance and regulation of transepithelial transport in the mammalian cortical collecting duct, a nephron segment responsible in the adult for the final renal regulation of total body K+ and Na+ homeostasis. Specifically, her lab continues to expand on two major discoveries: (1) unique developmental programs underlying the postnatal expression of ion channels responsible for Na absorption (ENaC) and K secretion (SK/ROMK and BK channels) in this epithelium, thus establishing the physiological basis for total body Na and K retention required for somatic growth and maintenance of blood pressure, and (2) the role of variations in urinary flow rate (i.e., hydrodynamic forces) in mechanoregulation of renal epithelial ion channels in health and disease. Recent efforts have been devoted to developing model systems, including 3D bioprinted collecting ducts and human PSC-derived kidney organoids, which recapitulate ion transport and signaling phenotypes of the in vivo distal nephron. As the lab serves as a national "single nephron physiology" Core of an NIH-funded O'Brien Center for Kidney Research, the techniques available to lab members and external investigators include in vitro microperfusion of single nephron segments, fluorescent functional imaging of single cells in native tissue (for measurement of cell pH, calcium, K+ and Na+), patch clamp studies of single cells for analysis of channel activity, and molecular techniques (real time PCR, immunoblotting) applied to single cells and tubules.