As leader of the Bone Marrow Transplantation (BMT) service at Mount Sinai, Dr. Isola promotes clinical and translational research on bone marrow transplantation. He has developed several protocols including non-ablative conditioning for allogeneic transplantation, the use of immunomagnetic technology for stem cell selection in haplo-mismatched transplantation and a combination of these two approaches for unrelated transplantation in older adults.

Under his leadership the Mount Sinai BMT service performed the first mismatched transplantation using non-ablative conditioning. It is also one of only a few in the country with a FDA-approved protocol for haplo-mismatched transplantation. This is particularly important for minority populations as it is exceedingly difficult to find matched unrelated donors for patients from minorities.

Also under his leadership, Mount Sinai was one of the first centers in the country to offer volunteer, unrelated peripheral blood stem cell collections for allotransplantation under the auspices of the National Marrow Donor Program. Dr. Isola has also been at the forefront in developing computerized systems for data management, capabilities that are crucial for maintaining accreditation by many organizations.