Sergio Lira, MD, PhD
- PROFESSOR | Medicine, Clinical Immunology
Research Topics:Autoimmunity, Cancer, Cell Motility, Cellular Immunity, Chemokines, Chemotaxis, Imaging, Immunology, Inflammation, Inflammatory Bowel Disease (IBD), Knockout Mice, Mucosal Immunology, Oncogenes, Organogenesis, Pathology, T Cells, Tolerance, Trafficking, Transgenic Mice, Tumorigenesis, Viruses and Virology
Professor of Medicine, Immunology Institute, Ichan School of Medicine at Mount Sinai.
Dr. Sergio Lira received his MD from the Universidade Federal de Pernambuco in Brazil (1982) and his PhD in Physiology and Pharmacology from the University of California at San Diego (1988). He did his postdoctoral training at the Roche Institute for Molecular Biology in Nutley, NJ. After his postdoctoral training he worked for 11 years in the pharmaceutical sector, first at Bristol-Myers Squibb (1992-1996) and then at Schering-Plough (1996-2002). Dr. Lira joined Mount Sinai in 2002 as the Irene Diamond Associate Professor of Immunology. In 2007 he became the co-Director of the Immunology Institute (with Dr. Lloyd Mayer), and in 2013 was promoted to Director, a position he occupied until 2016. He is currently The Leona M. and Harry B. Hemsley Charitable Trust Professor of Immunology. His research focuses on the role of immune cells and the microbiome in mucosal inflammation and cancer. He has organized international meetings in this field, including the 2003 Keystone Symposium on Chemokines, the 2006 Gordon Research Conference on Chemotactic Cytokines, and the 2012 Keystone Symposium on Chemokines and Leukocyte Trafficking. He was elected to the Henry Kunkel Society in 2006 and to the Association of American Physicians in 2008. He is a member of the Board of Scientific Counselors of NCI (2013-2019).
Multi-Disciplinary Training AreasCancer Biology [CAB], Immunology [IMM]
Post-doctoral, Roche Institute of Molecular Biology
MD, U. Federal de Pernambuco
PhD, University of California
Specific Clinical/Research Interest: Mucosal Immunology; Microbiota; Cancer; Inflammation; Chemokines; Leukocyte trafficking; Lymphoid Development; Mouse genetics; IL-23 biology
Co-PI: Glaucia Furtado, PhD. Associate Professor
Postdoctoral Fellows: Lili Chen, Zhengziang He, Grace Chen
Summary of Research Studies:
We use genetic approaches in mice to study the function of cytokines and their receptors in mucosal immunology, inflammation and cancer. Recent work in the laboratory focuses:
1) role of microbiome in inflammation in cancer.
2) impact of environmental factors such as diet in inflammation and autoimmunity
3) neonatal inflammation
For more information, please visit the Lira Lab page http://labs.icahn.mssm.edu/liralab/our-research-2/
Chen L, He Z, Iuga AC, Martins Filho SN, Faith JJ, Clemente JC, Deshpande M, Jayaprakash A, Colombel JF, Lafaille JJ, Sachidanandam R, Furtado GC, Lira SA. Diet Modifies Colonic Microbiota and CD4 T Cell Repertoire to Induce Flares of Colitis in Mice With Myeloid-cell Expression of Interleukin 23. Gastroenterology 2018 Jun;.
Meisel M, Hinterleitner R, Pacis A, Chen L, Earley ZM, Mayassi T, Pierre JF, Ernest JD, Galipeau HJ, Thuille N, Bouziat R, Buscarlet M, Ringus DL, Wang Y, Li Y, Dinh V, Kim SM, McDonald BD, Zurenski MA, Musch MW, Furtado GC, Lira SA, Baier G, Chang EB, Eren AM, Weber CR, Busque L, Godley LA, Verdú EF, Barreiro LB, Jabri B. Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host. Nature 2018 May; 557(7706).
Barsheshet Y, Wildbaum G, Levy E, Vitenshtein A, Akinseye C, Griggs J, Lira SA, Karin N. CCR8FOXp3 T cells as master drivers of immune regulation. Proceedings of the National Academy of Sciences of the United States of America 2017 06; 114(23).
Cummings RJ, Barbet G, Bongers G, Hartmann BM, Gettler K, Muniz L, Furtado GC, Cho J, Lira SA, Blander JM. Different tissue phagocytes sample apoptotic cells to direct distinct homeostasis programs. Nature 2016 11; 539(7630).
Peloquin JM, Goel G, Kong L, Huang H, Haritunians T, Sartor RB, Daly MJ, Newberry RD, McGovern DP, Yajnik V, Lira SA, Xavier RJ. Characterization of candidate genes in inflammatory bowel disease-associated risk loci. JCI insight 2016 Aug; 1(13).
Roulis M, Bongers G, Armaka M, Salviano T, He Z, Singh A, Seidler U, Becker C, Demengeot J, Furtado GC, Lira SA, Kollias G. Host and microbiota interactions are critical for development of murine Crohn's-like ileitis. Mucosal immunology 2016 05; 9(3).
Lira SA, Furtado GC. The biology of chemokines and their receptors. Immunologic research 2012 Dec; 54(1-3).
Chen L, He Z, Slinger E, Bongers G, Lapenda TL, Pacer ME, Jiao J, Beltrao MF, Soto AJ, Harpaz N, Gordon RE, Ochando JC, Oukka M, Iuga AC, Chensue SW, Blander JM, Furtado GC, Lira SA. IL-23 activates innate lymphoid cells to promote neonatal intestinal pathology. Mucosal immunology 2015 Mar; 8(2).
Bongers G, Pacer ME, Geraldino TH, Chen L, He Z, Hashimoto D, Furtado GC, Ochando J, Kelley KA, Clemente JC, Merad M, van Bakel H, Lira SA. Interplay of host microbiota, genetic perturbations, and inflammation promotes local development of intestinal neoplasms in mice. The Journal of experimental medicine 2014 Mar; 211(3).
Furtado GC, Pacer ME, Bongers G, Bénézech C, He Z, Chen L, Berin MC, Kollias G, Caamaño JH, Lira SA. TNFα-dependent development of lymphoid tissue in the absence of RORγt⁺ lymphoid tissue inducer cells. Mucosal immunology 2014 May; 7(3).
Shechter R, Miller O, Yovel G, Rosenzweig N, London A, Ruckh J, Kim KW, Klein E, Kalchenko V, Bendel P, Lira SA, Jung S, Schwartz M. Recruitment of beneficial M2 macrophages to injured spinal cord is orchestrated by remote brain choroid plexus. Immunity 2013 Mar; 38(3).
Farache J, Koren I, Milo I, Gurevich I, Kim KW, Zigmond E, Furtado GC, Lira SA, Shakhar G. Luminal bacteria recruit CD103+ dendritic cells into the intestinal epithelium to sample bacterial antigens for presentation. Immunity 2013 Mar; 38(3).
Bongers G, Muniz LR, Pacer ME, Iuga AC, Thirunarayanan N, Slinger E, Smit MJ, Reddy EP, Mayer L, Furtado GC, Harpaz N, Lira SA. A role for the epidermal growth factor receptor signaling in development of intestinal serrated polyps in mice and humans. Gastroenterology 2012 Sep; 143(3).
Dong X, Cheng A, Zou Z, Yang YS, Sumpter RM, Huang CL, Bhagat G, Virgin HW, Lira SA, Levine B. Endolysosomal trafficking of viral G protein-coupled receptor functions in innate immunity and control of viral oncogenesis. Proceedings of the National Academy of Sciences of the United States of America 2016 Mar; 113(11).