Terry F Davies, MD
- PROFESSOR | Medicine, Endocrinology, Diabetes and Bone Disease
- PROFESSOR | Obstetrics, Gynecology and Reproductive Science
Specialty:Endocrine, Diabetes and Bone Diseases
Research Topics:Autoimmunity, Genetics, Immunology, Knockout Mice, Receptors, Stem Cells, T Cells, Thyroid
Terry Francis Davies is the Florence and Theodore Baumritter Professor of Medicine at the Mount Sinai School of Medicine in New York and Director of their Division of Endocrinology and Metabolism at the James J. Peters VA Medical Center. Dr. Davies was trained in the UK, at the University of Newcastle upon Tyne but after training at the National Institutes of Health in Bethesda, MD, has spent most of his career in New York at the Mount Sinai School of Medicine. He has a long and distinguished record of significant contributions to our understanding of endocrine physiology and pathology having published over 400 peer reviewed scientific papers mostly in the area of thyroid disease at both a basic level, in the areas of immunology and genetics, and in the clinical arena in the area of autoimmune thyroid disease and pregnancy. Although Dr. Davies, as a clinician, is always included in the lists of New York's Best Doctors, the Davies Laboratory remains one of our pre-eminent sites for autoimmune thyroid disease research as evidenced by his extensive support from the National Institutes of Health. Dr. Davies has received many honors in his career, is a member of the American Association of Physicians and is the President-Elect of the American Thyroid Association. Dr. Davies was recently chosen by Women's Health as the pre-eminent Endocrinologist for women in New York City.
- Paget's Disease Of Bone
- Thyroid Cancer
- Vitamin D Deficiency
Multi-Disciplinary Training AreaBiophysics and Systems Pharmacology [BSP]
MD, University of Newcastle-Upon-Tyne
National Institute of Health
MD, University of New Castle-Upon-Tyne
Residency, Internal Medicine, University of Newcastle-Upon-Tyne
Residency, Endocrinology & Metabolism, University of Newcastle-Upon-Tyne
Fellowship, Endocrinology & Metabolism, National Institutes of Health
Honorary President for Life
Veterans Affairs Merit Award
Specific Clinical/Research Interest:
Mechanisms in autoimmune disease with an emphasis on autoimmune thyroid disease
Postdoctoral Fellows: Marco Agote-Robertson PhD, Sayed Moshad PhD, Chris Michalek MD, PhD, Risheng Ma, PhD
Research Personnel: Rauf Latif PhD, Xiaoming Yin PhD, Zhong Yao
Summary of Research Studies:
Research areas of emphasis include: The TSH receptor molecule: This is the major autoantigen in human Graves' disease which is a form of autoimmune hyperthyroidism. The TSHR remains an elusive quarry ten years after it was cloned becsue of its highly complex processing. Our emphasis is on the post translational processing events involved with multimerization and intramolecular cleavage of the TSHR and its status in lipid rafts. Complex Genetics: The aim of this research has been to detect the susceptibility genes for autoimmune thyroid disease using genome screening of informative families with Graves' disease and/or Hashimoto's thyroiditis. Our group has experience in the analysis of families with these disorders and we have a large collection of well characterized families to study. Currently, our areas of emphasis are on individual susceptibility genes. In particular the TSH receptor intron 1 region where we have identified miRNAs close to associated SNPs and the role of epigenetics(using X chromosome inactivation) in disease susceptibility and its influence on the autoimmune response. Animal models of autoimmune thyroid disease: We have developed models of hyperthyroid mice immunized with an adenoviral vector incorporating the TSH receptor as a model for Graves' disease. These studies involve the development and characterization of unique monoclonal antibodies to the TSH receptor with thyroid stimulating activity with an emphasis on epitope characterization and signal transduction.
Lu A, Ng L, Ma M, Kefas B, Davies TF, Hernandez A, Chan CC, Forrest D. Retarded developmental expression and patterning of retinal cone opsins in hypothyroid mice. Endocrinology 2008 Oct 30; Epub ahead of print.
Yin X, Latif R, Bahn R, Tomer Y, Davies TF. Influence of the TSH Receptor Gene on Susceptibility to Graves' Disease and Graves' Ophthalmopathy. Thyroid 2008 Oct 16;.
Menconi F, Monti MC, Greenberg DA, Oashi T, Osman R, Davies TF, Ban Y, Jacobson EM, Concepcion ES, Li CW, Tomer Y. Molecular amino acid signatures in the MHC class II peptide-binding pocket predispose to autoimmune thyroiditis in humans and in mice. Proc Natl Acad Sci U S A 2008 Sep 16; 105(37): 105-109.
Characterization of TSH receptor antibody induced signaling cascades [Epub ahead of print]. Endocrinology 2008 Aug 21;.
Ban Y, Greenberg DA, Davies TF, Jacobson E, Concepcion E, Tomer Y. Linkage analysis of thyroid antibody production: evidence for shared susceptibility to clinical autoimmune thyroid disease. J Clin Endocrinol Metab 2008 Sep; 93(9): 3589-3596.
Vieland VJ, Huang Y, Bartlett C, Davies TF, Tomer Y. A multilocus model of the genetic architecture of autoimmune thyroid disorder, with clinical implications. Am J Hum Genet 2008 Jun; 82(6): 1349-1356.
Sun L, Vukicevic S, Baliram R, Yang G, Sendak R, McPherson J, Zhu LL, Iqbal J, Latif R, Natrajan A, Arabi A, Yamoah K, Moonga BS, Gabet Y, Davies TF, Bab I, Abe E, Sampath K, Zaidi M. Intermittent recombinant TSH injections prevent ovariectomy-induced bone loss. Proc Natl Acad Sci U S A 2008 Mar 18; 105(11): 4289-4294.
Galofre JC, Lomvardis S, Davies TF. Evaluation and treatment of thyroid nodules: A clinical guide. Mount Sinai Journal of Medicine 2008; 75: 299-311.
Tomer Y, Menconi M, Davies TF, Barbesubi G, Rocchi R, Pinchera A, Concepcio E, Greenberg DA. Dissecting genetic heterogeneity in autoimmune thyroid diseases by subset analysis. Journal of Autoimmunity 2007; 29: 69-77.
Ando T, Latif R, Abe E, Davies TF. Antibody-induced modulation of TSH receptor post-translational processing. Journal of Endocrinology 2007; 195: 179-186.
Latif R, Davies TF. Lipid rafts as triage centers for multimeric and monomeric TSH receptor regulation. Endocrinology 2007; 148: 3164-3175.