Pancreatic Beta Cell Regeneration
In 2013 it is clear that both Type 1 and Type 2 Diabetes ultimately result from inadequate numbers of pancreatic beta cells, the cells that sense glucose and secrete insulin. Therefore permanent cure of diabetes requires therapeutic approaches that regenerate, expand, or create de novo new human pancreatic beta cells. The DOMI has a strong focus on discovering approaches to induction of human cadaveric pancreatic beta cell proliferation and expansion, supported by parallel studies in mouse genetic models. The DOMI islet group was the first to demonstrate, in contrast to conventional wisdom, that human cadaveric beta cells can be induced to replicate, both in vitro and in vivo. Designing approaches to effectuate this in humans in a safe and effective manner is one principal goal of the DOMI.
Diabetes, Obesity and Metabolism Institute
Mount Sinai Health System
One Gustave L. Levy Place
New York, NY 10029