Type 1 Diabetes Auto- and Allo-Immunity
Type 1 diabetes is caused by autoimmune destruction of the pancreatic beta cells in subjects with genetic predisposition to Type 1 diabetes. Therefore, effective treatment of Type 1 diabetes will require not only methods for beta cell production, replacement and/or regeneration, as described above, but also that the abnormal autoimmune destruction of beta cells be reversed once it occurs - or better yet - before beta cells are destroyed. Mount Sinai has an exceptionally strong Immunology Institute, focused on inflammatory bowel disease (Crohn’s Disease, Ulcerative Colitis). There is also a strong thyroid autoimmunity group in the Endocrinology Division at Mount Sinai. The Recanati/Miller Transplant Institute also has an excellent group focused on Transplant Immunology. The DOMI is collaborating with these three excellent groups to develop therapeutic approaches to auto- and allo-immune challenges associated with beta cell regeneration and replacement. The DOMI is also interested in recruiting high level experts in Type 1 Diabetes immunology. .
Diabetes, Obesity and Metabolism Institute
Mount Sinai Health System
One Gustave L. Levy Place
New York, NY 10029