Cancer Mechanisms

The main goal of the Cancer Mechanisms (CM) program is to facilitate basic research that is pertinent to improving the diagnosis, treatment and prevention of cancer. The premise of our program is that basic research on genetic, biochemical, and developmental pathways that drive cancer initiation and progression will reveal novel therapeutic targets for cancer. We recognize that effective identification and characterization of therapeutic targets must be grounded in detailed studies of human disease. CM investigators study important aspects of cancer development, perform gene discovery research in model organisms ranging from fission yeast to human cells and tissues, and explore mechanisms of cancer cell sensitivity and resistance to targeted therapy. Others are working directly with clinician scientists in the design and implementation of clinical trials for cancer therapeutics developed at the Icahn School of Medicine at Mount Sinai (ISMMS). All of these approaches play important roles in our overall goal of translating basic research advances in cancer to the clinical setting.

Program Leaders

Ross Cagan, PhD
Ramon Parsons, MD, PhD

Program Members

Name Degree(s) Title Department/Division (Primary)
Other Dept/Div
Aaronson, Stuart
MD Associate Director, Basic and Translational Research
Professor
Oncological Sciences
Medicine
Aggarwal, Aneel PhD Professor
Structural and Chemical Biology
Oncological Sciences
Anatomy and Functional Morphology
Aguirre-Ghiso, Julio PhD Professor
Otolaryngology
Medicine/Hematology and Medical Oncology
Oncological Sciences
Bernstein, Emily PhD Associate Professor Oncological Sciences
Dermatology
Cagan, Ross PhD Professor
Developmental and Regenerative Biology
Oncological Sciences
Ophthalmology
Celebi, Julide MD Professor Dermatology
Pathology
Chipuk, Jerry PhD Assistant Professor Oncological Sciences
Dermatology
Cordon-Cardo, Carlos MD, PhD Chair, Pathology Professor Pathology
Genetics and Genomic Sciences
Oncological Sciences
Dar, Arvin PhD Assistant Professor Oncological Sciences
Dominguez-Sola, David MD, PhD Assistant Professor Oncological Sciences
Pathology
Dudley, Joel PhD Assistant Professor Genetics and Genomic Sciences
Fisher, Robert PhD Associate Professor Structural and Chemical Biology
Gallagher, Emily MD Assistant Professor Medicine/Endocrinology, Diabetes and Bone Disease
Gallo, James PhD Professor
Pharmacology and Systems Therapeutics
Germain, Doris PhD Associate Professor Medicine/Hematology and Medical Oncology
Hoffman, Ronald MD Professor
Medicine/Hematology and Medical Oncology
Holcombe, Randall MD Deputy Director, The Tisch Cancer Institute
Professor
Medicine/Hematology and Medical Oncology
Irie, Hanna Yoko MD, PhD Assistant Professor
Medicine/Hematology and Medical Oncology
Oncological Sciences
Iyengar, Ravi PhD Professor Pharmacology and Systems Therapeutics
Lemischka, Ihor PhD Professor Developmental and Regenerative Biology
Pharmacology and Systems Therapeutics
LeRoith, Derek MD Professor Medicine/Endocrinology, Diabetes and Bone Disease
Ma'ayan, Avi PhD Associate Professor Pharmacology and Systems Therapeutics
Manfredi, James PhD Professor
Oncological Sciences
Developmental and Regenerative Biology
Mascarenhas, John MD Assistant Professor
Medicine/Hematology and Medical Oncology
Migliaccio, Anna Rita PhD Professor Medicine/Hematology and Medical Oncology
Mlodzik, Marek PhD
Chair, Developmental and Regenerative Biology
Professor
Developmental and Regenerative Biology
Oncological Sciences
Ophthalmology
Moore, Kateri D.V.M. Associate Professor Developmental and Regenerative Biology
Mulholland, David PhD Assistant Professor Medicine/Hematology and Medical Oncology
O'Connell, Matthew PhD Professor Oncological Sciences
Oh, William MD Associate Director, Clinical and Translational Research
Chief, Hematology and Medical Oncology Professor
Medicine/Hematology and Medical Oncology
Urology
Pan, Zhen-Qiang PhD Professor Oncological Sciences
Papapetrou, Eirini MD, PhD Associate Professor
Oncological Sciences
Medicine/Hematology and Medical Oncology
Parsons, Ramon MD, PhD
Chair, Oncological Sciences
Professor
Oncological Sciences
Pfleger, Cathie PhD Associate Professor Oncological Sciences
Poulikakos, Poulikos PhD Assistant Professor Oncological Sciences
Reddy, Premkumar PhD Professor Structural & Chemical Biology
Oncological Sciences
Schadt, Eric PhD Chair, Genetics and Genomic Sciences
Professor
Genetics and Genomic Sciences
Institute for Genomics and Multiscale Biology
Sidi, Samuel PhD Assistant Professor
Medicine/Hematology and Medical Oncology
Developmental and Regenerative Biology
Silva, Jose PhD Associate Professor Pathology
Silverman, Lewis MD Associate Professor
Medicine/Hematology and Medical Oncology
Oncological Sciences
Skobe, Mihaela PhD Associate Professor Oncological Sciences
Sokol, Sergei PhD Professor Developmental and Regenerative Biology
Soriano, Philippe PhD
Associate Director, Basic Science Shared Resources, Professor
Developmental and Regenerative Biology
Oncological Sciences
Walsh, Martin PhD Associate Professor
Pediatrics, Hepatology, Structural and Chemical Biology, Genetics and Genomic Sciences
Waxman, Samuel MD Distinguished Service Professor
Medicine/Hematology and Medical Oncology
Oncological Sciences
Yu, Qin PhD Associate Professor Oncological Sciences
Zhou, Ming-Ming PhD
Chair, Structural and Chemical Biology, Professor
Structural and Chemical Biology
Oncological Sciences
Pharmacology and Systems Therapeutics
Zhu, Jun PhD Professor Genetics and Genomic Sciences
Zwaka, Thomas MD, PhD Professor Developmental and Regenerative Biology