Alice O Silva(kamphorst) | Mount Sinai

Biography

Research Topics

Anti-Tumor Therapy, Immunology, Infectious Disease, Inflammation, Liver, Lymphocytes, T Cells, Translational Research, Viruses and Virology

Multi-Disciplinary Training Area

Cancer Biology [CAB], Immunology [IMM]

Alice O. Kamphorst, PhD is an Assistant Professor of Oncological Sciences at the Precision Immunology Institute. She is also a member of the Cancer Immunology Research Program at the Tisch Cancer Institute.

The Kamphorst lab focuses on T cell differentiation with a specific interest on situations of chronic antigen stimulation, such as in cancer. The research program aims to determine how inflammation, costimulation and other factors in the microenvironment influence CD8 T cell differentiation, dysfunction and rescue by immunotherapy. We study the interplay of different signaling pathways with the PD-1 (programmed cell death-1) pathway. To address those questions the lab uses mouse models of chronic viral infection and tumor, as well as analysis of samples from cancer patients.

https://kamphorstlab.org/

Alice O. Kamphorst, PhD is an Assistant Professor of Oncological Sciences at the Precision Immunology Institute. She is also a member of the Cancer Immunology Research Program at the Tisch Cancer Institute.

The Kamphorst lab focuses on T cell differentiation with a specific interest on situations of chronic antigen stimulation, such as in cancer. The research program aims to determine how inflammation, costimulation and other factors in the microenvironment influence CD8 T cell differentiation, dysfunction and rescue by immunotherapy. We study the interplay of different signaling pathways with the PD-1 (programmed cell death-1) pathway. To address those questions the lab uses mouse models of chronic viral infection and tumor, as well as analysis of samples from cancer patients.

https://kamphorstlab.org/

Research

T cell biology

The Kamphorst lab focuses on T cell differentiation with a specific interest on situations of chronic antigen stimulation, such as in cancer. The research program aims to determine how inflammation, costimulation and other factors in the microenvironment influence CD8 T cell differentiation, dysfunction and rescue by immunotherapy. We study the interplay of different signaling pathways with the PD-1 (programmed cell death-1) pathway. To address those questions the lab uses mouse models of chronic viral infection and tumor, as well as analysis of samples from cancer patients. The lab has a deep interest on how adaptive immune responses are modulated and on interventional strategies that can be used to improve human health. Understanding the factors that govern T cell differentiation and function will enable the identification of targetable molecules and pathways to improve the efficacy of immunotherapy.

Education

PhD, Rockefeller University

Postdoc, Emory University

Office Locations

Icahn (East) Building Floor 12th Room 12-02

1425 Madison Ave

New York, NY 10029

212-659-9429

Icahn (East) Building Floor 12th Room 12-20A

1425 Madison Ave

New York, NY 10029

212-659-9305

Industry Relationships

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Dr. Silva(Kamphorst) did not report having any of the following types of financial relationships with industry and other outside entities during 2024 and/or 2025: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.

Physicians and scientists on the faculty of the Icahn School of Medicine at Mount Sinai often interact with pharmaceutical, device, biotechnology companies and other outside entities to improve patient care, develop new therapies and achieve scientific breakthroughs. In order to promote an ethical and transparent environment for conducting research, providing clinical care and teaching, Mount Sinai requires that salaried faculty inform the School of their outside financial relationships.

Dr. Silva(Kamphorst) did not report having any of the following types of financial relationships with industry and other outside entities during 2024 and/or 2025: consulting, scientific advisory board, industry-sponsored lectures, service on Board of Directors, participation on industry-sponsored committees, equity ownership valued at greater than 5% of a publicly traded company or any value in a privately held company. Please note that this information may differ from information posted on corporate sites due to timing or classification differences.

Mount Sinai's faculty policies relating to faculty collaboration with industry are posted on our website. Patients may wish to ask their physician about the activities they perform for companies.