Institute for Regenerative Medicine

Research

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Understanding how our organs develop and renew themselves throughout life in healthy individuals, and how these processes are derailed in disease, has enormous potential to uncover new avenues for regenerative therapies. The scientists at the interdisciplinary Institute for Regenerative Medicine are carrying out cutting-edge basic, translational, and clinical research to alter stem cell activity, create new drugs, and generate cells and tissues for therapeutic transplantation to bring life-changing benefits to patients. By uncovering how normal, aging, and diseased tissues function, our researchers are committed to identifying better ways to treat congenital diseases, repair diseased or damaged tissues, promote healthy aging, and fight cancer.

Research Areas

Researchers at the Center for Advancement of Blood Cancer Therapies are working to uncover mechanisms of blood disorders such as leukemias and immune deficiencies using human models of normal and malignant blood-cell formation, specifically primary human cells, human-induced pluripotent cells, and transplants of patient cells into mice. They are using this information to develop new therapeutics, including conventional drugs and cell therapies.

Researchers at the Alper Center for Neural Development and Regeneration are studying brain development and disease and screening for new therapies for autism, age-related memory loss, Parkinson’s disease, and Alzheimer’s disease, among other conditions. Using animal models, our researchers study brain development and diseases in living organisms. Excitingly, our researchers have also developed methods which recreate human brain tissue in a dish. This enables the study of human-specific developmental and disease processes and screening for drugs that are specifically effective in humans and can be personalized to the individual patient.

At the Black Family Stem Cell Institute, our researchers are discovering how stem cells in the embryo give rise to tissues in normal development, how these mechanisms are altered in developmental diseases, and how adult stem cells are regulated in normal, aging, and diseased organs. Our researchers are developing ways to produce adult-like cells and tissues from human embryonic and induced pluripotent stem cells to model human disease in the dish, screen for drugs that can effectively treat these diseases, and generate therapeutic cells and tissues that can be used to replace or regenerate diseased, damaged, or aged tissues.

Epithelial tissues such as the skin, hair, and lung are maintained by specialized populations of cells. Decreased or altered activity of these cells underlies a range of diseases and conditions including inflammatory skin disease, hair loss, pulmonary disease (including risk of COVID-19 complications), and cancers. In the Center for Epithelial and Airway Biology and Regeneration, our researchers are conducting patient-oriented studies, including analyzing diseased human tissues at the single cell level. They are using sophisticated genetic approaches to study disease processes in mouse models and human cell-derived systems to better understand and treat these conditions.

Research Facilities

Bioinformatics for Next Generation Sequencing Facility
Flow Cytometry CoRE
Genomics Core Facility
Microscopy and Advanced Bioimaging CoRE
Mouse Genetics and Gene Targeting CoRE
Stem Cell Engineering CoRE

Contact Us

Institute for Regenerative Medicine

Icahn School of Medicine at Mount Sinai

1468 Madison Ave

New York, NY 10029

Nyomi Cepeda
Administrative Assistant

212-659-6897, ext. 86897
212-659-9653
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Jessica Bauza
Administrative Coordinator

212-241-6500, ext. 88312
212-659-9653
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Kendra Sturgeon
Technical Floor Manager, Icahn 13

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Alyssa Ferdinand
Technical Floor Manager, Atran 6 and 7

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