What We Do
“Standard of care” is not always enough for many of our most complex and most common diseases. The
Center for Personalized Cancer Therapeutics (CPCT) accepts patients who have failed more traditional treatments. Using the latest in basic scientific cancer research, we analyze your disease, generate animal models personalized to your disease, and use those models to identify candidate alternative treatments personalized to your tumor.
The current focus of CPCT is:
- Colorectal carcinoma
- Medullary thyroid carcinoma
By emphasizing these tumor types, we are gaining experience in new approaches for their treatment.
Basic Science has traditionally been separated from Clinical Science. The Icahn School of Medicine at Mount Sinai houses many of the very best researchers from both disciplines. CPCT is helping realize the vision of combining both.
At the CPCT, tumors are obtained from the patient and sequenced for DNA changes. This data is used to build a ‘personalized Drosophila cancer model’, essentially a fruit fly model of your tumor. We use robotics to screen these personalized flies against hundreds of drugs and drug combinations, looking for a drug cocktail that is tailored to the details of your tumor while seeking to minimize whole body toxicity. In this manner we use the tools of basic research to search for personalized medicines.
Three review boards of elite cancer scientists and clinicians monitor progress as the science is completed. They recommend specific treatments and monitor progress both of the science and of the patient. No trial can guarantee a successful outcome. But we bring many of the best cancer biologists together in a concerted effort to identify promising therapeutics.