The Tisch Cancer Institute

Shared Resources Facilities

The Tisch Cancer Institute (TCI) enables cutting-edge research by providing outstanding cores, equipment, facilities and information technology. TCI supports five shared resources and three cores-in-development to encourage interdisciplinary collaboration and foster the translation of scientific discoveries into novel cancer therapeutics. These facilities are supported by a Cancer Center Support Grant (CCSG) awarded by the National Cancer Institute (NCI) to TCI. Visit the individual shared resource and core-in-development websites below to explore the services provided.

Shared Resources

Biostatistics Shared Resource Facility (BSRF) contributes statistical services, such as study design for basic, population science and clinical studies; statistical analysis (including development of tables and graphics for presentation); interpretation of the findings in language understandable by the investigators; and assistance with manuscript preparation and revision.

Flow Cytometry Shared Resource Facility (FCSRF) provides access to state-of-the-art technologies, services, and expertise in flow cytometry to enhance scientific discovery, interaction, and productivity underlying innovative cancer research programs.

Human Immune Monitoring Center Shared Resource Facility (HIMCSRF) provides TCI members access to a comprehensive suite of immune monitoring assays allowing for the quantification of circulating proteins and immune cell characterization, along with spatial organization in tissues to support basic science, clinical, and translational studies.

Microscopy Shared Resource Facility (MSRF) provides TCI member’s access to equipment, training, expert consultation, and collaborative opportunities across a full-range of light and electron microscopy applications, including confocal, multiphoton, super-resolution, in vivo imaging, light sheet, widefield, and transmission electron microscopy (EM).

Mouse Genetics Shared Resource Facility (MGSRF) grants TCI members access to state-of-the-art facilities for the production of transgenic and knockout cancer models in mice, as well as related rodent embryology techniques.

Cores in Development

Biorepository & Pathology Core (BPC) brings TCI members improved access to solid tumor specimens and tissue acquisition. Services of the BPC include:

  • Collect and store solid tissue from surgical specimens (in excess of that which is required for patient care) to be distributed to investigators fresh, frozen, fixed or otherwise processed to investigator’s specifications.
  • Provide histologic service including tissue processing, embedding, sectioning, routine and special stains, immunohistochemistry, tissue microarray creation, digital slide scanning and laser capture microdissection.
  • Macromolecular services including DNA and RNA isolation from blood and frozen and FFPE tissue.
  • Provide tissue to support participation in clinical trials.

Bioinformatics for Next Generation Sequencing (BiNGS) provides computational analyses for cancer investigators.  The mission is to advise on experimental design and protocols related to NGS technologies, perform data analysis and visualization, and assist in data interpretation. The BiNGS facility aims to further scientific discoveries by establishing robust computational pipelines for analyzing NGS data for TCI member labs and for the wider Mount Sinai and global research community.

Biomedical Data Science and Informatics (BDSIS) brings structured access to reliable clinical data to foster population science and clinical research studies and to better understand the cancer concerns of our patient population.  As well as, to promote knowledge discovery and predictive analytics to identify optimal treatment trajectories and to improve cancer care. The BDSIS provides the infrastructure and processes to streamline the collection, storage and distribution of data to researchers, including gene sequencing and expression, microbiomics, EHR, cancer registry, radiology, pathology, and billing data.