The Tisch Cancer Institute

Shared Resources

The Tisch Cancer Institute (TCI) enables cutting-edge research by providing outstanding resources, equipment, facilities, and information technology. TCI supports five shared resources and three cores-in-development to encourage interdisciplinary collaboration and foster the translation of scientific discoveries into novel cancer therapeutics. These resources are supported by the Cancer Center Support Grant (CCSG) awarded by the National Cancer Institute (NCI) to the TCI.

Under the leadership of Jerry Edward Chipuk, PhD, continuous improvement of the shared resources is maintained through rigorous planning and evaluation mechanisms. Explore the services provided by each shared resource and core-in-development below.

The Biostatistics & Clinical Informatics Shared Resource (BCISR) works closely with TCI members to curate, compile, and analyze data for multidisciplinary research program design and publication. The principal objectives of BCISR are to ensure availability of biostatisticians with expertise in diverse types of cancer, as well as a comprehensive coverage of statistical methodologies and training. In parallel, BCISR manages structured access to clinical data to foster population science and clinical research studies, and to better understand the cancer concerns of our patient population.

For more information, visit the Biostatistics and Clinical Informatics Shared Resource

The Cancer Genomics Technologies Shared Resource (CGTSR) facilitates scientific, translational, and clinical breakthroughs by harnessing cutting-edge molecular -omics techniques, advanced instrumentation, and computational methods. The CGTSR offers TCI members the latest developments in bulk, single-cell, spatial, and in-situ multi-omics data generation platforms; while also providing expertise to optimize experimental design, data quality, and access.

For more information, visit the Genomics Core Facility.

The Flow Cytometry Shared Resource (FCSR) provides convenient and affordable access to flow cytometry technologies, including on-site access to high-speed fluorescence activity cell sorting (FACS) and advanced multiparameter flow cytometric analysis. The FCSR also offers technical expertise and training to guide investigators and their staff in the application of basic and advanced flow cytometry techniques.

For more information, visit the Flow Cytometry Shared Resource

The Microscopy Shared Resource (MSR) provides access to equipment, training, expert consultation, and collaborative opportunities across a full-range of light and electron microscopy application, including: confocal, multiphoton, super-resolution, in vivo imaging, light sheet, widefield, and transmission electron microscopy.

For more information, visit the Microscopy Shared Resource

The Mouse Genetics Shared Resource (MGSR) provides access to state-of-the-art facilities for the production of transgenic and knockout cancer models in mice using mouse embryonic stem cells or CRISPR/Cas9 gene editing.

For more information, visit the Mouse Genetics Shared Resource

The Human Immune Monitoring Center (HIMC) provides access to a comprehensive suite of immune monitoring assays allowing for the quantification of circulating proteins and immune cell characterization, along with spatial organization in tissues to support basic science, clinical, and translational studies.

For more information, visit the Human Immune Monitoring Center

The Biorepository and Pathology Shared Resource provides TCI members access to normal and diseased tissue specimens from broad diagnoses. They oversee tissue/body fluid procurement, storage, and tracking from consented and de-identified specimens, along with offering histological services that enable advanced analyses.

For more information, visit the Biorepository and Pathology Shared Resource

Bioinformatics for Next Generation Sequencing (BiNGS) provides computational analyses for cancer investigators. The mission is to advise on experimental design and protocols related to NGS technologies, perform data analysis and visualization, and assist in data interpretation. BiNGS aims to further scientific discoveries by establishing robust computational pipelines for analyzing NGS data for TCI member laboratories and for the wider Mount Sinai and global research communities.

For more information, visit Bioinformatics for Next Generation Sequencing

The TCI shared resources provide the TCI members access to specialized scientific expertise, consultation/assistance, infrastructure, and equipment necessary to conduct cutting-edge scientific research. The shared resources and cores are each directed by a TCI member with expertise and knowledge in that particular field of research. In addition to overseeing a facility/core, the directors maintain their own research and are core users themselves. The TCI shared resources aim to ensure that each one perform their function at the highest level of technology, service, and accessibility to members.

The TCI administration meet regularly with the shared resources leaders and administrators to review usage data and to address any operational or financial concerns. TCI administration works closely with Jerry Edward Chipuk, PhD, the Associate Director for Basic Science Shared Resources, to conduct annual TCI user surveys. The results of these surveys are reviewed with senior leadership through its planning and evaluation committees to implement subsidies and expand support and access to new members and research areas.

TCI members acknowledge the CCSG (P30-CA196521) in all publications, grants, and awards that include data or services derived from the TCI shared resources to ensure tracking of impact.

The CCSG provides TCI members with subsidized fees and priority access to many of the most utilized services within our cancer center.