The Tisch Cancer Institute

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Cancer Mechanisms

Cancer Mechanisms

The goal of the CM program is to catalyze basic research pertinent to cancer-relevant mechanistic discovery to generate new knowledge leading to enhanced diagnosis, treatment, and prevention of primary cancer and systemic recurrence of cancers highly represented in the TCI immediate catchment area. CM is dedicated to exceptional basic research concentrating on the tumor microenvironment (TME), cell signaling pathways, and epigenetic and transcriptional control in cancer.

Program Goals

  • Investigate cellular interactions within the tumor microenvironment
  • Elucidate cell signaling networks in cancer
  • Investigate epigenetics and gene regulation of tumor biology
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Cancer Mechanisms Research Program Leaders

Emily Bernstein, PhD
Emily Bernstein, PhD
PROFESSOR | Oncological Sciences
PROFESSOR | Dermatology
Scott L Friedman, MD
Scott L Friedman, MD
DEAN FOR COLLABORATIVE RESEARCH AND PARTNERSHIPS
PROFESSOR | Medicine, Liver Diseases
PROFESSOR | Pharmacological Sciences

Members

AT A GLANCE

Cancer Mechanisms Research

3148
Publications
1922
Press/Media

59 Researchers

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Recent Publications

IL13RA2-integrated genetically engineered mouse model allows for CAR T cells targeting pediatric high-grade gliomas. Acta neuropathologica communications

Invasion of glioma cells through confined space requires membrane tension regulation and mechano-electrical coupling via Plexin-B2. Nature Communications

LNP-RNA-mediated antigen presentation leverages SARS-CoV-2-specific immunity for cancer treatment. Nature Communications

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Moving the Field Forward

Find out how we collaborate to address cancer’s most complex challenges.

Stuart A. Aaronson, MD: 2024 Jacobi Medallion Recipient
Thomas Marron, MD, PhD – AACR Annual Meeting 2023
Ramon Parsons, MD, PhD: 2023 Jacobi Medallion Recipient
2022 Distinguished Scholar Award - Dr. Alice Kamphorst
Center of Excellence: Liver and Bile Duct Cancer
Tisch Cancer Institute COVID-19 Research Briefing: May 14, 2020
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Resources For You

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Contact Us

The Tisch Cancer Institute

One Gustave L. Levy Place

Box 1128

New York, NY 10029-6574

Christine Ponder, PhD, MPA
Director, Research Administration

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Patient Information
The Clinical Research Support Unit

212-824-7391
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