Chair, Department of Genetics and Genomic Sciences
Director, Icahn Institute for Genomics and Multiscale Biology
Senior Associate Dean, Precision Medicine
Icahn School of Medicine at Mount Sinai
Dr. Margolin is a recognized leader in developing machine learning algorithms to analyze large-scale molecular datasets to predict therapies specific for an individual patient and to infer the key cellular processes that underlie cancer drug susceptibility and other clinically relevant phenotypes. He is a passionate advocate of highly collaborative team-based research, and has developed software systems to enable collaborative analysis for several of the largest national and international projects in cancer genomics, cancer immunotherapy, stem cell research, and pediatric diseases.
As Chair of the Department of Genetics and Genomic Sciences, Dr. Margolin oversees a vibrant enterprise that is ranked fourth nationally among medical schools in National Institutes of Health funding for genetics research. The Department’s research encompasses the basic mechanisms of genetic regulation, translational genomics research, and genomic medicine. Additionally, the Department operates a state-of-the-art genetic testing laboratory and medical genetics clinic, and trains clinical fellows. As Director of the Icahn Institute for Genomics and Multiscale Biology, Dr. Margolin leads a world-class computational genomics Institute focused on integrating the digital universe of biomedical data to advance discovery and delivery of revolutionary treatments.
Dr. Margolin joined Mount Sinai from Oregon Health & Science University, where he was Director of Computational Biology and Professor of Biomedical Engineering and led the University’s computational research and informatics software development programs. Previously, Dr. Margolin was the Director of Computational Biology at Sage Bionetworks in Seattle. He also worked as a postdoctoral fellow and staff scientist at the Broad Institute of Harvard and the Massachusetts Institute of Technology, where he lead an effort to leverage large-scale cancer genomics datasets to infer genotype-specific therapeutics in human tumors.
Dr. Margolin earned his BS in Economics from the Wharton School of Business at the University of Pennsylvania, MS in Computer Science from the School of Engineering at the University of Pennsylvania, and his PhD in Biomedical Informatics from Columbia University.