Key programs of ConduITS – the Institutes for Translational Sciences include:
The ORS is a component of ConduITS that serves as a central resource for the Mount Sinai Health System (MSHS) research community and functions as the point of integration among the core programs of ConduITS. The ORS acts as a liaison between ConduITS and the National CTSA Network of hubs. ORS provides innovative tools, services and consultations that accelerate and streamline research operations for the MSHS.
- Research 411 - Research Help Desk-The ORS Research 411 Portal provides a single point of contact for research teams to ask any research operations related questions and access assistance with the consultative services that the ORS offers. These include ClinicalTrials.gov registrations & reporting, IND & IDE application support, protocol development, training & education, recruitment, and multi-site study development & coordination. The Research 411 Portal is also a component of RKS in action.
- Research Roadmap (RRM) - The Research Roadmap is a centralized, dynamic, interactive web-based tool being optimized by the ORS to assist research teams in navigating the methods and processes of the MSHS research infrastructure and study lifecycles. Locally designed and built in our previous CTSA funding cycle, it is complementary to the Research 411 portal as an independent platform to find the most current information about the Mount Sinai research infrastructure, workflows and requirements. The RRM allows users to follow routes designed like a subway map. Each of the colored “lines” provides navigation for a pathway. Specific to Regulatory Support Knowledge, the RRM provides a platform where solutions to regulatory methods, process issues, gaps and unmet needs are identified by the RPNs and through Research 411 will be implemented. The RRM will make the location of RKS methods and process solutions easier to pinpoint and communicate.
- Clinical Trials Management System (CTMS) - The system-wide CTMS (OnCore) will impact rapid activation of clinical trials by enhanced protocol and informed consent life cycle management improving IRB approval duration and continuing renewal. The CTMS will centralize and streamline the sharing of regulatory and study documents among staff, eliminating redundant data entry and enabling real-time access to the most current, approved documents by remote study teams, which reduces the chances for use of outdated consent forms and other documents. Additionally, the CTMS will allow for the analysis of slow or non-recruiting studies for evaluation and improvement of initial recruitment plans or study closure. The CTMS will also increase regulatory compliance with clinical research billing and Clinicaltrials.gov registration and reporting.
- E-Lab Notebook (ELN) - LabArchives - LabArchives is an innovative and secure, cloud-based ELN designed to replace paper notebooks and to help improve designing and documenting experiments in order to enhance rigor and reproducibility. The service enables researchers to better track progress, streamline lab logistics, share data and results, and report their findings. All files, images, attachments, and other forms of data entered into the ELN are immediately backed up and protected in an encrypted format via a cloud network. The ELNs are designed to meet the data management requirements of various funding agencies, including the National Institutes of Health (NIH). ORS personnel worked collaboratively with the ORI The Office of Research Integrity to facilitate implementation of the E-Lab notebook. For more information about how to access the ELN click here.
- Office of the Chief Research Informatics Officer (CRIO/BEACON) - The Office of Chief Research Informatics Officer (CRIO) oversees the Mount Sinai IT needs related to research infrastructure, data science and informatics education, taking advantage of the unique data assets, diverse patient population and informatics resources of the entire Mount Sinai Health System. The CRIO provides critical support to the School’s precision medicine initiative by bridging academic research needs with Mount Sinai’s clinical information systems and expanding IT infrastructure supporting clinical and translational research including e-consenting capabilities integrated with institution-wide bio-banking efforts.
- Research Information Technology - Mount Sinai's Research Information Technology department provides services and resources to support the research institutes, centers, and laboratories within the Icahn School of Medicine at Mount Sinai. Through our tools and guidance, we meet your information technology needs through every step of the research process.
Community & Collaboration
- Community Engagement - ConduITS provides various resources for the research community including training, education, and development. Please see the ConduITS page For Community.
- Team Science - Team science approaches scientific challenges by leveraging the strengths and expertise of professionals trained in different fields. Although traditional single-investigator driven approaches are ideal for many scientific endeavors, coordinated teams of investigators with diverse skills and knowledge can be especially helpful for studies addressing multi-factorial problems, such as climate change, the rise of chronic disease, and the health impacts of social stratification.
- Translational Workforce Development - ConduITS provides graduate and postgraduate research training programs, a series of educational programs for new investigators and members of our community, as well as ongoing training through workshops, seminars, and lectures for staff We continue to move from a more traditional educational platform promoting multidisciplinary team science which draws on different disciplines with team members contributing within the boundaries of their individual expertise, to a transdisciplinary learning culture encouraging research that extends beyond discipline-specific concepts, approaches, and methods to accelerate progress toward solving increasingly complex health problems over the lifespan. . For more information, please see the ConduITS page Education and Career Development.
- Leadership Emerging in Academic Departments Program (LEAD) - Leadership skills are critical for the success of faculty at all stages of development and are of particular importance in the emerging landscape of Team Science. The curriculum includes modules in self-discovery, communication, influence, negotiation, difficult conversations, inspiring trust and embracing diversity.
- Mini-Sabbaticals - are opportunities for researchers to attend short courses in order to acquire added competencies in specific areas of translational research, with the experience tailored to meet each investigator's professional development needs: 1) new Transdisciplinary (TD) research (e.g., Gordon Conferences, coursework; rotations in outside laboratories to learn new techniques, new phone apps in the Mount Sinai AppLab); or 2) new MSHS TD leadership roles in Clinical Informatics & Data Science, Genomics & Precision Medicine, Digital Health, or Exposomics. To request more information click here.
- COMING SOON: A 3 month Mini-Sabbatical to be funded annually ($30,000 Direct Cost cap) based upon a competitive RFA 1-page application. Applicants accepted into the 3-month Mini-Sabbatical program will be jointly accepted into the LEAD program to further advance their research careers. To request further information click here.
- Education Accelerator
- Training Short Courses
- Life Course Research & Priority Populations Annual Retreat
- Regulatory Science (RS) Training: Product Development Ecosystem
- Social Media-based TD Journal Club - For more information about these programs contact: Layla Fattah, M.Ed.
Pilot Translational & Clinical Studies
- Center for Patient Oriented Research, Training, Education, and Development (CePORTED) - The overall mission of (CePORTED) is to facilitate the recruitment, training, mentoring, and retention of individuals considering or committed to careers in clinical/translational (C/T) research in order to improve individual patient care and the well-being of society.
- Patient Oriented Research Training and Leadership Program (PORTAL) - The program is designed to encourage the career development of medical students who seek to become leaders as physician-scientists in translational clinical research. Through our multidisciplinary approach, as a student in the PORTAL program you obtain rigorous didactic and practical training in the field of clinical investigation from the very beginning.
- 4D Pilot Projects
- The intent of the CTSA Translational 4D Pilot Program is to develop innovative technologies and methodologies, to test the feasibility of novel approaches, and to stimulate inter-disciplinary collaborations that test generalizable solutions to translational research problems.
- A Request for Proposal (RFP) is announced annually via the Research Listserv during the 2nd quarter of the calendar year. Awards of up to $40k are granted. Submissions in the areas of therapeutics, devices, diagnostic technologies, and digital health are all eligible.
- The 4D pilot projects are selected based on their potential for achieving milestones in plans to develop solutions to identified medical needs. The program encourages innovative, novel submissions. For more information, contact Louise Lammers, PhD.
- Biostatistics, Epidemiology & Research Design (BERD) - offers an integrated resource for clinical and translational investigators across the Mount Sinai Health System in study design, biostatistics, and bioethics. To access BERD assistance, please see the Resources section within our For Investigators page.
- Regulatory Knowledge and Support (RKS) - Through the Research 411 Help Desk RSK and support is available to assist investigators with research operations related questions and access assistance with the consultative services and regulatory support. These include ClinicalTrials.gov registrations & reporting, IND & IDE application support, protocol development, training & education, recruitment, and multi-site study development & coordination.
- Recruitment of Research Participants - Subject recruitment and retention is a challenge often faced in clinical research. To address this challenge, it is important that recruitment and retention is considered early on during budget development and negotiation. Successful subject recruitment also involves developing and implementing a recruitment plan that utilizes multiple recruitment strategies.
Hub Research Capacity
- Integrating Special Populations - International Center for Health Outcomes and Innovation Research (InCHOIR) - is a clinical and data coordinating center with an interdisciplinary faculty. InCHOIR faculty are expert in study design, clinical coordination, regulatory approval and management, endpoint and event adjudication and Data Safety and Monitoring Board management. In addition, faculty has expertise in data management, statistical analysis, health economics, and FDA-compliant web-based electronic data capture systems.
- The multi-disciplinary Hub Liaison Team of the ORS and TIN - are available for researchers to learn about the resources available locally at ISMMS through ConduITS and the International Center for Health Outcomes (InCHOIR). As part of the national network of CTSA Hubs, the additional resources of the Trial Innovation Network (TIN) are also available to MSHS researchers for studies that require support not available locally. Please place a Research 411 Help Desk ticket for Multi-Site Support to access the following resources.
- Trial Innovation Network - The Trial Innovation Network (TIN) is a collaborative initiative of the NCATS/Clinical Translational Science Award (CTSA) program that seeks to address critical roadblocks in clinical trials and accelerate the translation of novel research into clinical practice by leveraging the expertise, skills and knowledge of the entire CTSA Consortium. Through its CTSA grant, ISMMS ConduITS is a member of the TIN that provides investigators with a broad range of services and consultations to optimize multi-site studies through the development of proposals into protocols, streamlining of study operations, and enhancement of recruitment and enrollment.
- Multi-site Study Support - The ORS helps investigators to identify and navigate the resources available to MSHS researchers planning to conduct Multi-Site Research Studies. To request a consultation with the Hub Liaison Team, please place a Research 411 Help Desk ticket for Multi-Site Support as noted in the section above.
- CTSA Network Central Resources - Links to other CTSA Network resources can be located on the Research Road Map here: http://researchroadmap.mssm.edu/ctsa/
- Mount Sinai Imaging Research Warehouse (MS-IRW) - The MSSM Imaging Research Warehouse (IRW). The first of its kind in New York City was developed by the BioMedical Engineering and Imaging Institute (BMEII) through support of the MSHS CTSA. The IRW integrates clinical imaging with electronic health records, and as it expands it will give researchers new access to information about more than 1 million Mount Sinai patients. The IRW will revolutionize clinical care and translational research ultimately improving human health.
- Federated Biobank and Biobanking Resources - can be found under Resources on the ConduITS For Investigators page.
- LabVantage - is an ISMMS biorepository management system used to support ad hoc sample collection as well as defined protocol-driven sample collection. Donor registration, consent, and common sample annotation can be captured in a single system to ease the future sample search and report. This system also uses role-based access control to protect donor’s privacy. This system tracks the sample processing, storage condition, and the chain of custody to provide a complete picture about a sample’s lineage.
NRSA Training Core
- KL2 Scholars Award for Clinical and Translational Research Career Development - The Institutes for Translational Sciences at the Icahn School of Medicine at Mount Sinai (CONDUITS) offers a KL2 Scholars Award for Clinical and Translational Research Career Development for outstanding junior faculty and Postdoctoral fellows. This career development program is funded through the Institution’s (CTSA), and administered by the Center for Patient-Oriented Research, Training, Education and Development (CePORTED).
- PORTAL Program - The Patient-Oriented Research Training and Leadership program is a highly mentored dual degree program that you may be eligible for if you are experienced in the clinical research environment and want to create a foundation for a career in translational research. PORTAL offers you the unique opportunity to earn a dual MD/MSCR degree.
- Sinai Team-based Translational Education Program: the URM Propeller Initiative in Science and Medicine (STTEP-UP) - This program is designed to enable highly motivated URM trainees in residency, subspecialty fellowship training or postdoctoral laboratory positions within our health care system, to become innovative leaders and entrepreneurs in clinical and translational research and to provide candidates with the critical thinking skills to evaluate the validity and implications of the published literature and plethora of available information through digital and internet resources; formulate testable hypotheses, design informative, effective and efficient studies, analyze data correctly and interpret quantitative and qualitative findings and their potential impact on the health of individuals across the life cycle.