The Department of Genetics and Genomic Sciences at the Icahn School of Medicine at Mount Sinai is dedicated to advancing biomedical discovery and translating it into clinical impact. Our faculty work across the full spectrum of genomic medicine—from identifying key regulators of gene activity involved in Alzheimer’s disease, to delivering first-in-human gene therapies for rare metabolic disorders and advancing them into first-in-human clinical trials, to developing AI-powered tools that make precision medicine more accurate and more equitable for patients of all backgrounds.

Our research addresses diseases that present some of the greatest scientific and clinical challenges, from common, genetically complex disorders to rare conditions that have historically been difficult to diagnose or treat. We are uncovering early biomarkers that may one day allow us to intercept Crohn's disease before it develops. We are using whole-genome sequencing to help resolve diagnostic odysseys for patients with rare and previously uncharacterized conditions. We are developing patient-derived organoid models that bring personalized cancer treatment closer to reality. And we are integrating genomic and microbiome research to identify therapeutic opportunities that might not emerge from either field alone.

By bringing together discovery science, advanced technologies, clinical expertise, and clinical research within a single department, we accelerate the translation of genomic insights into new diagnostics, therapies, and clinical trials. This work is grounded in a shared conviction that understanding the genome within the broader biological and environmental context of human health is essential to transforming how we prevent, diagnose, and treat disease. Consistently ranked among the nation’s leaders in NIH funding for genetics research, we are positioned to lead that transformation and committed to translating it into better outcomes for patients across populations.

Alison M. Goate, DPhil
Jean C. and James W. Crystal Professor and Chair, Department of Genetics and Genomic Sciences
Icahn School of Medicine at Mount Sinai