The Joseph Schein, MD Endowed Fellowship in Experimental/Molecular Pathology

Marco Matthias Hefti, MD, has been named the second Joseph Schein, MD Fellow at Mount Sinai’s Lillian and Henry M. Stratton-Hans Popper Department of Pathology. The fellowship emphasizes training in experimental neuropathology in addition to training in clinical neuropathology and the provision of high-quality patient care.

About Dr.Hefti

Dr.Hefti is a neuropathologist who earned his medical degree at the Icahn School of Medicine at Mount Sinai. After completing a residency in surgery at Beth Israel Deaconess Medical Center in Boston, Dr.Hefti focused his studies on the process of human disease and concluded his pathology fellowship and residency. During his time there, Dr.Hefti received funding to conduct research on the pathology of sudden and unexpected death in pediatric patients at Boston Children’s Hospital. Additional funding was granted to investigate the expression of alpha-synuclein in gastrointestinal biopsies of Parkinson’s disease patients as a possible biomarker. His findings have been published in multiple medical journals.

Carlos Cordon-Cardo, MD, PhD, Irene Heinz Given and John LaPorte Given Professor of Pathology and Chairman of the Department of Pathology, notes that “Dr.Hefti is someone who is really moving the field forward with deep insights into molecular pathways, cell biology, and genetics. He also has an understanding of information technology in pathology which is vital as the Department is growing its personalized precision medicine program.” 

About the Schein Fellowship

The Joseph Schein, MD Endowed Fellowship in Experimental/Molecular Pathology was established in 2013 to honor Dr. Schein and his long-standing belief in the value of pathology and its impact on medical practice, patient care, and the advancement of medicine. Dr. Schein began his career with Mount Sinai as a fellow in 1943. Now age 102, he remains engaged in the field.

Dr.Schein graduated from Princeton with a degree in humanities–modern languages in 1937 and from the School of Medicine at the University of Pennsylvania in 1941. He was mentored by Abraham Flexner, founder of the Institute for Advanced Studies. At Penn, Dr.Schein met and married his wife of 75 years, the late Dr.Selma Snyderman, who forged a distinguished career in pediatric research, notably diseases of inborn errors of metabolism.

After a rotating internship at Newark City Hospital where he was a protégé of Harrison Martland (Professor of Forensic Medicine at NYU), Dr.Schein started a life-long and continuing relationship with Mount Sinai through a series of fellowships. He served for many years as the liaison psychiatrist, first to medicine and then to neurology. He worked closely with Drs.Klemperer and Otani in the Pathology Department, and then became a fellow on George Baehr’s service because of his interest in “Psychosomatic” medicine, including work on the pioneering “Ward A” under the tutelage of Dr.Kaufman.

At the same time, because of major activity in neuro-hormonal research (Hans Selye et al), he elected to study at the New York Psychoanalytic Institute and was trained by Dr.Paul Federn, one of Freud’s most trusted colleagues. Throughout his career as a practicing psychiatrist, Dr.Schein has never wavered in his conviction that, even in that field, there was no better training than the one originated in the 18th century by Giambattista Morgagni at the School of Padua in his famous treatise De Sedibus et causis morborum per anatomem indagatis. He is especially honored that his attachment to pathology is being recognized through this endowed fellowship.