Emergency Medicine Research

The Research Division is committed to developing and enhancing the research skills of its faculty, fellows, residents, and students and to providing the resources and support needed to conduct state-of-the-art clinical, translational, and health services research. Consistently ranked in the top ten NIH-funded Emergency Medicine research programs in the country, the Division is home to a cadre of world-class clinician-scientists studying an array of conditions to advance medical knowledge, preserve health, and improve health care.

We are committed to collaborative, multidisciplinary research across the entire translational spectrum. We are currently ranked within the top five among departments of emergency medicine in the United States by the Blue Ridge Institute for Medical Research with respect to National Institutes of Health (NIH) funding, up from fifth the previous year.  Two of our faculty members are ranked among the top 20 investigators in Emergency Medicine.

We have a portfolio of more than 30 awards totaling over $20 million. The portfolio includes four R01 grants, 2 U01 awards, an R03, a VA merit Award, 2 K23 grants and a variety of foundation funding. We are a leader in emergency care research training with a prestigious K12 program and our recently awarded T32 program to train emergency care research fellows, as well as three NIH Research Diversity Supplements. In addition our Emergency Medicine Research Training Program is a year-round training program for undergraduate post-baccalaureate, medical, and graduate students.

Research Projects

Our ongoing research includes:

  • Community VOICES 3: Views on Informed Consent in Emergency Situations (R01)
  • Prevention and Early Treatment of Acute Lung Injury (U01)
  • New York City Sickle Cell Implementation Science Consortium (U01)
  • Geriatric Emergency Department Collaborative (Hartford/West Health)
  • Advancing Quality Measurement & Care Improvement with Health Information Exchange (R01)
  • Terminology Services To Reduce Avoidable CT Imaging (R01)
  • Improving Cardiovascular Outcomes in Overdose (R01)
  • Inhaled Mometasone To Promote Reduction In Vaso-occlusive Events” (IMPROVE) (K23)
  • Comparing Acute Pain Management Protocols for Patients with Sickle Cell Disease (R34 Site)
  • Promoting Innovation in EMS” (DOT)
  • Transport Plus (R03)
  • Shared Decision Making in Syncope” (K23)
  • Apex-Radial Pulse Deficit As A Predictor of Declining Cardiovascular Function and Response to Therapy in Patients With Atrial Fibrillation (4D Tech Development  Pilot)
  • Heart Rate Volatility as a Predictor of ED Outcomes (K12)
  • Management of Undiagnosed or Uncontrolled Hypertension in the Emergency Department (EMF)
  • The Extracorporeal Removal of N-acetylcysteine in Overdose Patients (R01 Supplement)
  • IRB Decision-Making in Exception from Informed Consent (EFIC) Studies (R01 Supplement)
  • Identifying Human Trafficking Survivors in the Emergency Department
  • Assessing Appropriateness of Community Representation among Community Consultation Participants  (R01 Supplement)
  • Choosing Wisely: Improving the Value of Emergency Care (EMF)

Research Spotlight

Alex F. Manini, MD, MS, FACMT, Associate Professor of Emergency Medicine, has received funding through a Research Project Grant (R01) from the NIH. The five-year, $3.4 million award involves collaboration between Mount Sinai investigators in neuroscience, cardiology, epidemiology, emergency medicine, and medical toxicology, along with co-investigators from the NYU School of Medicine and a national registry sponsored by the American College of Medical Toxicology. Clinical studies launched by the R01 will test a broad array of risk prediction instruments, laboratory biomarkers, and single nucleotide polymorphisms. The overall goal of the project is to produce clinical tools that individualize prevention strategies and curtail the national rise in drug overdose fatality.

Dr. Manini's other funded research studies include an innovative NIDA National Early Warning System Network (iN3), which is designed to detect emerging patterns of psychoactive drug use and adverse effects by harmonizing data streams from medical toxicologists who specialize in treating the effects of acute substance use. Mount Sinai serves as one site in a national network that collects data from emerging psychoactive drug use, with information from investigators' bedside interviews of drug overdose patients. This project will have substantial public health impact by informing professionals and policy makers of current, emerging drug use trends. The ultimate goal is to provide early warning on emerging drugs of abuse using a national network for qualitative data collection.