In 2015 the National Institutes of Health (NIH) awarded two grants to Mount Sinai to further its research in the emergent field of exposomics. Children’s Health Exposure Analysis Resource (CHEAR) was established to provide tools for researchers to assess the full range of environmental exposures that may affect children’s health. Mount Sinai was the only institution to receive two of CHEAR’s three component grants.
The Data Center, led by principal investigator Susan Teitelbaum, PhD, addresses methodology for combining data from a wide range of environmental health studies, while developing precise vocabularies for semantically accelerating the exposomics field and statistical approaches for analyzing exposomic/chemical mixtures. The center also performs BIG data science, integrating exposomics with genomics and epigenomics. Other key investigators in the Data Center include Chris Gennings, PhD and Patricia Kovatch of Mount Sinai, and RPI’s Deborah McGuinness, PhD.
The CHEAR Lab Hub led by principal investigator Robert O. Wright, MD, MPH, is based in The Senator Frank R. Lautenberg Environmental Health Sciences Laboratory and consists of a Targeted Chemical Analysis Resource, a Biological Response Resource, an Untargeted Chemical Analysis (i.e., “Exposomic”) Resource, and a Development Core that generates unique biomarker measures of environmental exposure with a special emphasis on reconstructing past exposure. Other key investigators in the Lab Hub include Manish Arora, BDS, MPH, PhD, Mary S. Wolff, PhD, and Rosalind Wright, MD.