The Mount Sinai Institute for Exposomic Research is the nucleus of the Icahn School of Medicine’s work on studying environmental exposures and their effects on life health, disease, and development. With our transdisciplinary research program, expertise, and analytical capabilities, we are designing innovative exposure measures and studying a vast array of health outcomes, from childhood to later life. These include childhood obesity, asthma, renal disease, cancer, autism, postpartum depression, learning disabilities, PTSD, and ALS (Lou Gehrig’s disease), as well as the health status of the World Trade Center responders cohort. We focus not only on finding causes of diseases but on what helps us maintain and improve our health at every stage of life. Our goal is to translate our findings into new strategies for prevention and treatment.